著者

Taiki Miyazawa Kiyotaka Nakagawa Fumiko Kimura Yuya Nakashima Isao Maruyama Ohki Higuchi Teruo Miyazawa

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.62, no.10, pp.773-779, 2013 (Released:2013-10-02)

参考文献数

22

被引用文献数

3 20

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Chlorella contains a high amount of carotenoids, especially lutein, and has received attention as a possible dietary source for improving carotenoid levels in human blood. In the present study, we performed a 2-month single arm human study, and investigated the efficacy of Chlorella supplementation (9 g Chlorella/day; equivalent to 32 mg lutein/day) on lutein and other carotenoid concentrations in plasma as well as erythrocytes of 12 healthy subjects. Following Chlorella supplementation, lutein was the predominant carotenoid in erythrocytes, showing a 4-fold increase (from 14 to 54 pmol/mL packed cells). After the one month without Chlorella ingestion, erythrocyte lutein then decreased to a basal level (17 pmol/mL packed cells). Erythrocyte carotenoid (lutein, zeaxanthin, α-carotene, and β-carotene) levels were proportional to plasma carotenoid levels. The results suggest the transfer of Chlorella carotenoids, especially lutein, from plasma lipoprotein particles to the erythrocyte membrane. Chlorella intake would be effective for improving and maintaining lutein concentrations in human erythrocytes.

著者

木村 富美子 Fumiko Kimura

出版者

創価大学通信教育部学会

雑誌

通信教育部論集 (ISSN:13442511)

巻号頁・発行日

no.16, pp.52-68, 2013-08-11

著者

Taiki Miyazawa Kiyotaka Nakagawa Hideo Takekoshi Ohki Higuchi Shunji Kato Momoko Kondo Fumiko Kimura Teruo Miyazawa

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.62, no.11, pp.873-881, 2013 (Released:2013-11-06)

参考文献数

22

被引用文献数

3 25

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Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact for a total of 2 months Chlorella supplementation (8 g Chlorella/day/person; equivalent to 22.9 mg lutein/day/person) on PLOOH and carotenoid concentrations in erythrocytes as well as plasma of 12 normal senior subjects. After 1 or 2 months of treatment, erythrocytes and plasma lutein concentrations increased in the Chlorella group but not in the placebo group. In the Chlorella-supplemented group, erythrocyte PLOOH concentrations after a total of 2 months of treatment were lower than the concentrations before supplementation. These results suggest that Chlorella ingestion improved erythrocyte antioxidant status and lowered PLOOH concentrations. These reductions might contribute to maintaining the normal function of erythrocytes and prevent the development of senile dementia.

著者

Sayaka Tomatsu Masaki Takahashi Masakazu Kakuni Gen Toshima Fumiko Kimura Junichiro Takahashi Yui Umekawa Akira Sasaki Keishi Hata

出版者

Japan Science Society of Biological Macromolecules

雑誌

Journal of Biological Macromolecules (ISSN:13472194)

巻号頁・発行日

vol.21, no.1, pp.51, 2021 (Released:2021-01-20)

参考文献数

6

著者

Taiki MIYAZAWA Kiyotaka NAKAGAWA Fumiko KIMURA Akira SATOH Teruo MIYAZAWA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.75, no.9, pp.1856-1858, 2011-09-23 (Released:2011-09-23)

参考文献数

15

被引用文献数

26

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A randomized, double-blind human trial was conducted to assess the effect on the plasma carotenoid concentration of 4- or 12-week astaxanthin supplementation (1 or 3 mg/d) of 20 Japanese middle-aged and senior subjects. The plasma carotenoid concentration was significantly higher after the astaxanthin supplementation than that before in both the 1 mg/d (10 subjects) and 3 mg/d (10 subjects) groups.