著者

Miyuki Tsuchihashi Hiroyuki Tsutsui Kazunori Kodama Fumiyoshi Kasagi Akira Takeshita

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.64, no.12, pp.953-959, 2000 (Released:2001-05-31)

参考文献数

36

被引用文献数

80 80

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The clinical characteristics and prognosis of patients with congestive heart failure (CHF) have been described by a number of previous studies, but very little information is available on this issue in Japan. This study aimed to delineate the clinical characteristics and prognosis of Japanese patients hospitalized with CHF. Medical records were reviewed for 230 consecutive patients at 5 teaching hospitals in Fukuoka, Japan from January to December 1997 and the survival and hospital readmission were followed through December 1999 (mean follow-up, 2.4 years). The study population had a high mean age, contained a larger population of women especially in the older ages, and had a higher incidence of overt HF (48%) despite a relatively normal ejection fraction on echocardiography. Major causes of CHF were ischemic, valvular, and hypertensive heart diseases. The 1-year mortality rate was as low as 8.3% whereas rates of hospital readmission because of an exacerbation of CHF were as high as 40% during the follow-up period. Patients hospitalized with CHF in routine clinical practice in Japan have characteristics that differ from those in the population included in community-based studies or large clinical trials.

著者

Shin'ichi KUDO Keiko YOSHIMOTO Hiroshige FURUTA Kazumasa INOUE Masahiro FUKUSHI Fumiyoshi KASAGI

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.53, no.3, pp.146-153, 2018 (Released:2018-11-27)

参考文献数

41

被引用文献数

7

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Whether exposure to radiation at low dose and at low dose rate is related to leukemia mortality and morbidity remains controversial. Cohort studies of nuclear workers chronically exposed to radiation at low dose and at low dose rate in their workplaces provide an opportunity to directly evaluate the risks of leukemia in the lower dose ranges. Previous findings have come mostly from Western countries, with few from Asian countries. The present study aimed to examine radiation’s effects on mortality from leukemia, in a cohort of Japanese nuclear workers. The cohort consisted of 204,103 workers, who were followed from 1991 to 2010, with a total of 2.89 million person-years. The mean age and mean cumulative dose at the age at the end of follow-up were 55.6 years and 13.8 mSv. During the study, 209 leukemia deaths were observed. The linear excess relative risk (ERR) for all types of leukemia was negative, but not significant (ERR/Sv = -0.54; 90% confidence interval; -4.04, 2.96). Specific types of leukemia also showed no significant risks. A significant radiation-leukemia association for mortality was not observed in this study of Japanese nuclear workers. The cohort, however, is still young. Further follow-up is needed to obtain more reliable estimates of leukemia risks for Japanese workers exposed to low dose and low-dose rate radiation.

著者

Shin’ichi KUDO Akemi NISHIDE Jun’ichi ISHIDA Keiko YOSHIMOTO Hiroshige FURUTA Fumiyoshi KASAGI

出版者

Japan Health Physics Society

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.55, no.1, pp.32-39, 2020-04-01 (Released:2020-05-21)

参考文献数

26

被引用文献数

2 2

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The health effects of low-dose or low-dose rate of radiation are still controversial. There is little evidence to show if radiation risk is greater than other risks, such as lifestyle or socio-economic factors, including smoking. This study aimed to directly compare radiation and smoking risk on cancer mortality by deriving both risk factors simultaneously from one cohort. The study population was Japanese nuclear workers who were engaged until the end of March, 1999. A lifestyle questionnaire was distributed in 1997 and 2003 and smoking information was obtained. Radiation dose was supplied by Radiation Dose Registration Center in Radiation Effects Association. Poisson regression was used to derive radiation excess relative risk (ERR) per 100 mSv and smoking (ERR) per 20 pack-years. Radiation doses were lagged by 10 years. There were 71,733 subjects. The total person-years was 591,000, and the number of deaths for all cancers excluding leukemia was 1,326. For all cancers excluding leukemia, the ERR of radiation per 100 mSv was 0.08 (90% CI: −0.08, 0.28), and the ERR of smoking per 20 pack-years was 0.57 (90% CI: 0.44, 0.73). In addition to all cancers excluding leukemia, stomach cancer, lung cancer, smoking-related cancers showed significantly smaller radiation ERRs than smoking ERRs. These results suggest that, even if a low-dose radiation risk existed, it was much smaller than smoking risk.

著者

Gen SUZUKI Ichiro YAMAGUCHI Hiromitsu OGATA Hideo SUGIYAMA Hidenori YONEHARA Fumiyoshi KASAGI Saeko FUJIWARA Yoshimi TATSUKAWA Ippei MORI Shinzo KIMURA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.6, pp.683-689, 2010 (Released:2010-11-23)

参考文献数

23

被引用文献数

28

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In two previous nation-wide surveys in the late 1980s and early 1990s, Japanese indoor radon concentrations increased in homes built after the mid 1970s. In order to ascertain whether this trend continued, a nation-wide survey was conducted from 2007 to 2010. In total 3,900 houses were allocated to 47 prefectures by the Neyman allocation method and 3,461 radon measurements were performed (88.7% success). The fraction of reinforced concrete / concrete block buildings was 32.4%, similar to the value from national statistics. Arithmetic mean (standard deviation, SD) and geometric mean (geometric SD) of radon concentration after adjusting for seasonal fluctuation were 14.3 (14.7) and 10.8 (2.1) Bq/m3. The corresponding population-weighted values were 13.7 (12.3) and 10.4 (2.0) Bq/m3, respectively. It was estimated that only 0.1% of dwellings exceed 100 Bq/m3, a new WHO reference level for indoor radon. Radon concentrations were highest in houses constructed in the mid 1980s and decreased thereafter. In conclusion, arithmetic mean indoor radon in the present survey was slightly lower than in previous surveys and significant reductions in indoor radon concentrations in both wooden and concrete houses can be attributed to alterations in Japanese housing styles in recent decades.