- 著者
- Keiko ISHII Takahiko MASUDA Masahiro MATSUNAGA Yasuki NOGUCHI Hidenori YAMASUE Yohsuke OHTSUBO
- 出版者
- Psychologia Society
- 雑誌
- PSYCHOLOGIA (ISSN:00332852)
- 巻号頁・発行日
- pp.2021-B014, (Released:2021-07-21)
- 参考文献数
- 61
- 被引用文献数
- 1
The dopamine D4 receptor gene (DRD4) is associated with novelty-seeking and risk-taking behaviors that have had an adaptive value in the history of human migration. It also plays a role in moderating the extent to which people adhere to cultural norms and practices. The aim of this study was to replicate previous findings about how DRD4 polymorphism interacts with cultural differences in social orientation, which revealed Westerners’ emphasis on independence and East Asians’ emphasis on interdependence. Testing Japanese and European Canadian undergraduates (n = 784), we succeeded in replicating these previous findings: the Canadian students were more independent, whereas the Japanese students were more interdependent. However, none of the interaction effects between culture and DRD4 were significant. Implications for candidate gene research investigating gene–environment and gene–culture interactions are discussed.
- 著者
- Chie Sakanaka Ryoko Ihara Akiko Kishi Kenji Kirihara Gaku Oguri Mihoko Shibuya Kazushi Suzuki Keiko Ueda Yumi Umeda-Kameyama Mitsutaka Yakabe Tomohiro Haga Hidenori Yamasue
- 出版者
- Japanese Pharmacological Society
- 雑誌
- 日本薬理学会年会要旨集 (ISSN:24354953)
- 巻号頁・発行日
- pp.OR6-3, 2018 (Released:2020-09-10)
- 被引用文献数
- 3 4
Background:Autism spectrum disorder (ASD) is a neurodevelopmental disorder, mainly exhibit problems in social communication/interaction behaviors. ASD is shown to affect one out of 100 individuals, however, the cause and the established treatments on the core symptoms of ASD are unavailable. Recently, peptide hormone Oxytocin showed some promises in treating ASD core symptoms, and various clinical studies are currently underway. The objective of this study is to evaluate the safety and pharmacokinetics of new formulation of intra-nasal Oxytocin in healthy Japanese male.Methods:In this double-blind, randomized, placebo-controlled Phase1 study, 5 cohorts of eight subjects received a single dose of intranasal TTA-121 at dose levels of 5, 10, 30, 100 and 200 U/ml or placebo and 3 cohorts of eight subjects received 30, 100 and 200 U/ml or placebo at repeated doses for 9 days. Safety assessments were conducted throughout the study.Results:Regarding safety, no serious adverse events were reported and no clinically significant findings were observed throughout the study. A linear relationship between plasma concentration of Oxytocin and administered dose of TTA-121 (5 to 200 U/ml) was observed. There was no drug accumulation after multiple doses of intra-nasal Oxytocin.Conclusions:TTA-121 was well tolerated and safe in Japanese healthy male subjects after administration of multiple doses up to 200U/ml, BID for 9 days.Trial Registration:UMIN000025922