- 著者
- Hiroko Sonoda Worapat Prachasilchai Hiroaki Kondo Naoko Yokota-Ikeda Sayaka Oshikawa Katsuaki Ito Masahiro Ikeda
- 出版者
- The Japanese Pharmacological Society
- 雑誌
- Journal of Pharmacological Sciences (ISSN:13478613)
- 巻号頁・発行日
- vol.112, no.2, pp.242-246, 2010 (Released:2010-02-18)
- 参考文献数
- 15
- 被引用文献数
- 9 11
Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.
- 著者
- Toshihiko Takemura Hisashi Nakamura Masayuki Takigawa Hiroaki Kondo Takehiko Satomura Takafumi Miyasaka Teruyuki Nakajima
- 出版者
- Meteorological Society of Japan
- 雑誌
- SOLA (ISSN:13496476)
- 巻号頁・発行日
- vol.7, pp.101-104, 2011 (Released:2011-07-02)
- 参考文献数
- 13
- 被引用文献数
- 72 80
The powerful tsunami generated by the massive earthquake that occurred east of Japan on March 11, 2011 caused serious damages of the Fukushima Daiichi Nuclear Power Plant on its cooling facilities for nuclear reactors. Hydrogen and vapor blasts that occurred until March 15 outside of the reactors led to the emission of radioactive materials into the air. Here we show a numerical simulation for the long-range transport from the plant to the U.S. and even Europe with a global aerosol transport model SPRINTARS. Large-scale updraft organized by a low-pressure system traveling across Japan from March 14 to 15 was found effective in lifting the particles from the surface layer to the level of a westerly jet stream that could carry the particles across the Pacific within 3 to 4 days. Their simulated concentration rapidly decreases to the order of 10-8 of its initial level, consistent with the level detected in California on March 18. The simulation also reproduces the subsequent trans-Atlantic transport of those particles by a poleward-deflected jet stream, first toward Iceland and then southward to continental Europe as actually observed.