著者

Emiko KINOSHITA Kyoko HAYASHI Hiroshi KATAYAMA Toshimitsu HAYASHI Akio OBATA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.76, no.9, pp.1633-1638, 2012-09-23 (Released:2012-09-23)

参考文献数

27

被引用文献数

58

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Elderberry (Sambucus nigra L.) has traditionally been used for treating influenza and colds. We evaluated the antiviral effect of concentrated juice of elderberry (CJ-E) on the human influenza A virus (IFV). CJ-E had a relatively strong effect on IFV-infected mice, although its anti-IFV activity was weak in a cell culture system. The in vivo anti-IFV activities of the fractions were determined after separating CJ-E by ultrafiltration and anion-exchange chromatography. Oral administration of the high-molecular-weight fractions of CJ-E to IFV-infected mice suppressed viral replication in the bronchoalveolar lavage fluids (BALFs), and increased the level of the IFV-specific neutralizing antibody in the serum, as well as the level of secretory IgA in BALFs and feces. Fr. II from high-molecular-weight fraction HM, which contained acidic polysaccharides, showed relatively strong defense against IFV infection. We conclude that CJ-E had a beneficial effect by the stimulating immune response and preventing viral infection.

著者

片山 寛 カタヤマ ヒロシ Hiroshi KATAYAMA

出版者

西南学院大学学術研究所

雑誌

西南学院大学神学論集 (ISSN:03874109)

巻号頁・発行日

vol.69, no.1, pp.71-109, 2012-03

著者

片山 寛 カタヤマ ヒロシ Hiroshi KATAYAMA

出版者

西南学院大学学術研究所

雑誌

神学論集 (ISSN:03874109)

巻号頁・発行日

vol.68, no.1, pp.77-93, 2011-03