- 著者
- Akihito Yokoyama Hiroshi Okazaki Naoyuki Makita Ayako Fukui Yi Piao Yoshifumi Arita Yohji Itoh Naoki Tashiro
- 出版者
- Japanese Society of Allergology
- 雑誌
- Allergology International (ISSN:13238930)
- 巻号頁・発行日
- vol.71, no.1, pp.47-54, 2022 (Released:2022-01-27)
- 参考文献数
- 18
- 被引用文献数
- 7
Background: In Japan, regional differences in asthma mortality have been reported; however, regional differences in asthma exacerbations have not been studied extensively. Therefore, using a health insurance claims database, we investigated the regional differences in the incidence of asthma exacerbations in Japan.Methods: This study used data from Medi-Scope (Japan Medical Information Research Institute Inc., Japan)-a nationwide health insurance claims database. Patients with asthma at the index date (the latest date of an asthma-related prescription with an asthma diagnosis before October 1, 2018) were included in the analysis. The pre-index period was defined as 1 year before the index date, and the follow-up period as 1 year after the index date. The incidence of asthma exacerbation events was analyzed for each region.Results: The primary analysis population comprised 24,883 patients who were continuously prescribed ICS or ICS/LABA at least four times during the pre-index period. The incidence rate of asthma exacerbations with hospitalization was the highest in Chugoku (2.95/100 person-years [95% CI, 1.97-4.43]) and the lowest in Kanto (1.52/100 person-years [95% CI, 1.26-1.83]). The incidence rate of asthma exacerbations for the composite outcome of hospitalization, injectable corticosteroid prescription, and oral corticosteroid burst was the highest in Fukui (105.00/100 person-years [95% CI, 64.53-170.85]) and the lowest in Nagasaki (15.69/100 person-years [95% CI, 10.84-22.72]).Conclusions: Regional differences in the incidence of asthma exacerbations as well as their treatments were observed in Japan.
- 著者
- Atsushi FUKUDA Hiroshi OKAZAKI Shoichi NARAHASHI
- 出版者
- The Institute of Electronics, Information and Communication Engineers
- 雑誌
- IEICE TRANSACTIONS on Electronics (ISSN:09168516)
- 巻号頁・発行日
- vol.E105-C, no.12, pp.740-749, 2022-12-01
This paper presents a novel frequency-controlled beam steering scheme for a phased-array antenna system (PAS). The proposed scheme employs phase-controlled carrier signals to form the PAS beam. Two local oscillators (LOs) and delay lines are used to generate the carrier signals. The carrier of one LO is divided into branches, and then the divided carriers passing through the corresponding delay lines have the desired phase relationship, which depends on the oscillation frequency of the LO. To confirm the feasibility of the scheme, four-branch PAS transmitters are configured and tested in a 10-GHz frequency band. The results verify that the formed beam is successfully steered in a wide range, i.e., the 3-dB beamwidth of approximately 100 degrees, using LO frequency control.
- 著者
- TOSHIAKI HAYASHI TAKAO NOTO YOSHIHARU NAWATA HIROSHI OKAZAKI MIKIO SAWADA KUNIO ANDO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.35, no.7, pp.771-777, 1982 (Released:2006-04-12)
- 参考文献数
- 17
- 被引用文献数
- 16 25
A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.