著者

Hiroshi Okada Keiji Yoshioka

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.49, no.19, pp.2113-2116, 2010 (Released:2010-10-01)

参考文献数

6

被引用文献数

7 9

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A 73-year-old woman was admitted to our hospital because of persistent fever, headache and fatigue for several weeks. On admission, she was diagnosed as having meningitis due to Mycobacterium intracellulare (M. intracellulare) detected in her cerebrospinal fluid (CSF) by polymerase chain reaction. Even though anti-tuberculous therapy improved her CSF findings, her condition was not restored. Brain MRI showed multifocal and asymmetrical increases in T2 signals involving white matter and cortical gray-white junction of cerebral hemispheres, cerebellum and brainstem. Based on the progression of clinical symptoms and radiological features, we diagnosed her illness as acute disseminated encephalomyelitis (ADEM) associated with meningitis due to M. intracellulare. Steroid therapy dramatically improved her condition. This is the first report of ADEM following meningitis due to M. intracellulare in a non-immunocompromized host.

著者

Hiroshi Okada Mitsuko Onda Masaki Shoji Naoki Sakane Yasushi Nakagawa Takashi Sozu Yui Kitajima Ross T. Tsuyuki Takeo Nakayama

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2017.01256, (Released:2017-12-18)

参考文献数

30

被引用文献数

11 28

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The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by their pharmacy randomization. Patients in the intervention group received brochures and healthy lifestyle advice from pharmacists using motivational interviewing methods during pharmacy visits over a 12-week period, with their usual pharmacy care. Conversely, the control group just received usual care. The main outcome measure was a change in morning systolic blood pressure (SBP) from baseline to week 12. The intervention group exhibited a decrease in morning SBP that was 6.0 mmHg greater than that of the control group (95% confidence interval [CI]: −11.0 to −0.9, p = 0.021). In a mixed-effect model for repeated measures analysis, the intergroup difference in morning SBP decrease was −4.5 mmHg (95% CI: −8.5 to −0.6, p = 0.024). Our findings indicate that implementation of a lifestyle advice program in pharmacies is feasible and may lead to reduced blood pressure.

著者

HIROSHI OKADA HIROKAZU TSUKAYA MOTOHARU OKAMOTO

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.54, no.1, pp.69-75, 2003-06-09 (Released:2017-03-23)

参考文献数

13

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Cayratia japonica showed intra-specific polyploidy of x=20, i.e., 2n=40 (diploid) and 60 (triploid). Individuals with 2n=40 produced fruits, and formed 20 bivalents at metaphase I in meiosis, but their pollen fertilities widely varied from about 30 to 90%. Individuals with 2n=60 did not produce any fruits, formed a variable number of trivalents, bivalents and univalents at metaphase I, and showed low pollen fertilities of less than 30%. The possible occurrence of some genetic types for pollen development in diploids is discussed.

著者

Hiroshi Okada Mitsuko Onda Masaki Shoji Naoki Sakane Yasushi Nakagawa Takashi Sozu Yui Kitajima Ross T. Tsuyuki Takeo Nakayama

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

vol.11, no.6, pp.632-639, 2017-12-31 (Released:2018-01-09)

参考文献数

30

被引用文献数

13 28

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The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by their pharmacy randomization. Patients in the intervention group received brochures and healthy lifestyle advice from pharmacists using motivational interviewing methods during pharmacy visits over a 12-week period, with their usual pharmacy care. Conversely, the control group just received usual care. The main outcome measure was a change in morning systolic blood pressure (SBP) from baseline to week 12. The intervention group exhibited a decrease in morning SBP that was 6.0 mmHg greater than that of the control group (95% confidence interval [CI]: −11.0 to −0.9, p = 0.021). In a mixed-effect model for repeated measures analysis, the intergroup difference in morning SBP decrease was −4.5 mmHg (95% CI: −8.5 to −0.6, p = 0.024). Our findings indicate that implementation of a lifestyle advice program in pharmacies is feasible and may lead to reduced blood pressure.

著者

Soh Yoshida Hiroshi Okada Takahiro Ogawa Miki Haseyama

出版者

映像情報メディア学会

雑誌

ITE Transactions on Media Technology and Applications (ISSN:21867364)

巻号頁・発行日

vol.1, no.3, pp.237-243, 2013 (Released:2013-07-01)

参考文献数

19

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This paper presents a new method to improve performance of SVM-based classification, which contains a target object detection scheme. The proposed method tries to detect target objects from training images and improve the performance of the image classification by calculating the hyperplane from the detection results. Specifically, the proposed method calculates a Support Vector Machine (SVM) hyperplane, and detects rectangular areas surrounding the target objects based on the distances between their feature vectors and the separating hyperplane in the feature space. Then modification of feature vectors becomes feasible by removing features that exist only in background areas. Furthermore, a new hyperplane is calculated by using the modified feature vectors. Since the removed features are not part of the target object, they are not relevant to the learning process. Therefore, their removal can improve the performance of the image classification. Experimental results obtained by applying the proposed methods to several existing SVM-based classification method show its effectiveness.