文献一覧: Naoki Sakane (著者)

2 0 0 0 OA Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial

著者: Hiroshi Okada Mitsuko Onda Masaki Shoji Naoki Sakane Yasushi Nakagawa Takashi Sozu Yui Kitajima Ross T. Tsuyuki Takeo Nakayama
出版者: International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌: BioScience Trends (ISSN:18817815)
巻号頁・発行日: pp.2017.01256, (Released:2017-12-18)
参考文献数: 30
被引用文献数: 11 28

The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by their pharmacy randomization. Patients in the intervention group received brochures and healthy lifestyle advice from pharmacists using motivational interviewing methods during pharmacy visits over a 12-week period, with their usual pharmacy care. Conversely, the control group just received usual care. The main outcome measure was a change in morning systolic blood pressure (SBP) from baseline to week 12. The intervention group exhibited a decrease in morning SBP that was 6.0 mmHg greater than that of the control group (95% confidence interval [CI]: −11.0 to −0.9, p = 0.021). In a mixed-effect model for repeated measures analysis, the intergroup difference in morning SBP decrease was −4.5 mmHg (95% CI: −8.5 to −0.6, p = 0.024). Our findings indicate that implementation of a lifestyle advice program in pharmacies is feasible and may lead to reduced blood pressure.

2021-05-22 14:56:22
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2 0 0 0 OA Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial

著者: Junichi MINAMI Noriyuki IWABUCHI Miyuki TANAKA Koji YAMAUCHI Jin-zhong XIAO Fumiaki ABE Naoki SAKANE
出版者: BMFH Press
雑誌: Bioscience of Microbiota, Food and Health (ISSN:21863342)
巻号頁・発行日: vol.37, no.3, pp.67-75, 2018 (Released:2018-07-26)
参考文献数: 43
被引用文献数: 74

Accumulating evidence suggests a relationship between the gut microbiota and the development of obesity, indicating the potential of probiotics as a therapeutic approach. Bifidobacterium breve B-3 has been shown to exert anti-obesity effects in high-fat diet-induced obese mice. In the present study, the anti-obesity effects of the consumption of B. breve B-3 by healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a randomized, double-blind, placebo-controlled trial (trial registration: UMIN-CTR No. 000023919; preregistered on September 2, 2016). Eighty participants were randomized to receive placebo or B. breve B-3 capsules (2 × 1010 CFU/day) daily for 12 weeks. The visceral fat area significantly increased at weeks 4 and 8 in the placebo group only; no significant change was observed in the B-3 group. Body fat mass and percent body fat were significantly lower in the B-3 group than in the placebo group at weeks 8 and 12 (p<0.05, ANCOVA adjusted with baseline values). Although no significant differences were observed in blood parameters between the groups, the intake of B. breve B-3 slightly decreased triglyceride levels and improved HDL cholesterol from the baseline. No serious adverse effects were noted in either group. These results suggest that the probiotic strain B. breve B-3 has potential as a functional food ingredient to reduce body fat in healthy pre-obese individuals.

2018-09-07 18:04:53
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2 0 0 0 OA Aminopeptidase N/CD13 Regulates the Fetal Liver Microenvironment of Hematopoiesis

著者: Naoki Sakane Yoko Asano Tomoko Kawamura Tomohiro Takatani Yasuhiro Kohama Kazutake Tsujikawa Hiroshi Yamamoto
出版者: 公益社団法人日本薬学会
雑誌: Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日: vol.27, no.12, pp.2014-2020, 2004 (Released:2004-12-01)
参考文献数: 29
被引用文献数: 1 2 3

Fetal liver (FL) hematopoiesis is thought to be important for expanding the cell number during ontogeny. In order to investigate the cellular interaction molecules among FL stromal and hematopoietic cells, we established a monoclonal antibody, Ndk-10, that reacts with FL stromal cells but not with dish non-adherent cells. When Ndk-10 was added to an FL stromal and hematopoietic cell-coculture, it inhibited the survival of c-kit+ cells. The inhibitory activity of Ndk-10 was also observed in the fetal liver organ culture. The Ndk-10 recognized a 150 kD molecule in the adherent cells of FL and kidney, and the N-terminal amino acid sequence was identical to that of mouse aminopeptidase N/CD13. The peptidase activity of CD13 was inhibited by Ndk-10, and addition of its specific inhibitor resulted in the same inhibitory activity as Ndk-10. We propose that aminopeptidase N/CD13 is a critical molecule that regulates the survival of c-kit+ cells in the FL microenvironment.

2014-07-05 20:42:50
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1 0 0 0 OA Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial

著者: Hiroshi Okada Mitsuko Onda Masaki Shoji Naoki Sakane Yasushi Nakagawa Takashi Sozu Yui Kitajima Ross T. Tsuyuki Takeo Nakayama
出版者: International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌: BioScience Trends (ISSN:18817815)
巻号頁・発行日: vol.11, no.6, pp.632-639, 2017-12-31 (Released:2018-01-09)
参考文献数: 30
被引用文献数: 13 28

2021-07-10 02:15:27
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1 0 0 0 OA Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly

著者: Narumi Nagai Satomi Yagyu Anna Hata Shinsuke Nirengi Kazuhiko Kotani Toshio Moritani Naoki Sakane
出版者: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌: Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日: pp.18-104, (Released:2019-03-07)
参考文献数: 43
被引用文献数: 30

Maslinic acid, derived from olive fruit, reduces pro-inflammation cytokines, which are involved in muscle fiber atrophy. Therefore, the maslinic acid ingestion may enhance the muscular response to resistance training through anti-inflammatory action. We therefore conducted a parallel, double-blind, randomized, placebo-controlled trial that examined whether a combination of maslinic acid supplementation and resistance training improve mobility functions in community-dwelling elderly persons. Over a 12-week period, 36 participants underwent moderate resistance training and are assigned to the maslinic acid supplementation (n = 17, 60 mg/day) or the placebo (n = 19) group. At baseline and at 12-weeks, we assessed body composition, grip strength, walking speed, leg strength, mobility functions, and knee pain scores. Following the 12-weeks, skeletal muscle mass, segmental muscle mass (right arm, left arm, and trunk) and knee pain score of the right leg were significantly improved in the maslinic acid group, while there was no change or parameters had worsened in the placebo group. Grip strength of the better side significantly increased only in the maslinic acid group. These results suggest that maslinic acid supplementation combined with moderate resistance training may increase upper muscle mass and grip strength, and reduce knee pain, could be effective for preventing mobility-related disability in elderly persons. Clinical trial registration number: UMIN000017207.

2019-03-13 07:00:00
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