- 著者
- Koutaro Yokote Kiyoshi Niwa Tomomi Hakoda Fumiki Oh Yoshitaka Kajimoto Toshiki Fukui Hyosung Kim Yoshinori Noda Torbjörn Lundström Toshitaka Yajima
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-19-0358, (Released:2020-04-11)
- 参考文献数
- 27
- 被引用文献数
- 5
Background:This study is the first to evaluate the short-term efficacy and long-term safety of AZD0585, a mixture of omega-3 free fatty acids, in Japanese patients with dyslipidemia.Methods and Results:In this randomized double-blind placebo-controlled Phase III study, 383 patients were randomized to 2 g AZD0585, 4 g AZD0585, or placebo once daily for 52 weeks. Eligible patients had low-density lipoprotein cholesterol (LDL-C) levels controlled regardless of statin use, and triglyceride levels between 150 and 499 mg/dL. The least-squares (LS) mean percentage changes in triglyceride concentrations from baseline to the 12-week endpoint (mean of measurements at Weeks 10 and 12) in the 2 and 4 g AZD0585 and placebo groups were −15.57%, −21.75%, and 11.15% respectively (P<0.0001 for both AZD0585 doses vs. placebo). No clinically significant changes from baseline to the 12-week endpoint in total cholesterol, LDL-C, and LDL-C/apolipoprotein (Apo) B were found with AZD0585. High-density lipoprotein cholesterol (HDL-C) was slightly increased and very low-density lipoprotein cholesterol, non-HDL-C, ApoC-II, and ApoC-III were decreased with AZD0585 compared with placebo at the 12-week endpoint. Lipid profiles up to Week 52 were consistent with those up to the 12-week endpoint. No clinically important safety concerns were raised.Conclusions:AZD0585 significantly decreased serum triglyceride levels compared with placebo at the 12-week endpoint and was generally safe and well tolerated in Japanese patients with dyslipidemia.
- 著者
- Hirofumi Akagi Satoshi Ogasawara Hyosung Kim
- 出版者
- The Institute of Electrical Engineers of Japan
- 雑誌
- IEEJ Transactions on Industry Applications (ISSN:09136339)
- 巻号頁・発行日
- vol.119, no.12, pp.1461-1470, 1999-12-01 (Released:2008-12-19)
- 参考文献数
- 18
- 被引用文献数
- 5
This paper discusses “the p-q theory” and “the cross-vector theory” in three-phase four-wire systems, with the focus on similarity and difference between the two theories. They are perfectly identical if no zero-sequence voltage is included in a three-phase three-wire system. However, they are different in definition of the instantaneous active power and instantaneous reactive power in each phase if a zero-sequence voltage or current is included in a three-phase four-wire system. Based on both theory and computer simulation, this paper leads to the following conclusions: An instantaneous reactive-power compensator without energy storage components can fully compensate for the neutral current even in a three-phase four-wire system including a zero-sequence voltage or current, when a proposed control strategy based on the p-q theory is applied: However, the compensator cannot compensate for the neutral current fully, when a conventional control strategy based on the cross-vector theory is applied.