著者

Hirohisa Takano Ken-ichiro Inoue

出版者

日本毒性病理学会

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.30, no.3, pp.193-199, 2017 (Released:2017-07-20)

参考文献数

14

被引用文献数

28

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Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies. For example, diesel exhaust particles (DEPs), which are an agglomeration of particles and a wide array of chemical substances, aggravate asthma, primarily due to the principle organic chemical components of DEPs. In addition, environmental chemicals such as phthalate esters, which are commonly used as plasticizers in plastic products, also aggravate atopic dermatitis. It has also become evident that extremely small nanomaterials and Asian sand dust particles can enhance allergic inflammation. While the underlying mechanisms that cause such aggravation are becoming clearer at the cellular and molecular levels, methods to easily and quickly evaluate (screen) the ever-increasing amount of environmental pollutants for exacerbating effects on allergies are also under development. To eliminate and control allergic diseases, medical measures are necessary, but it is also essential to tackle this issue by ameliorating environmental changes.

著者

井上 一郎 笹川 隆太郎 Ichiro INOUE Ryutaro SASAGAWA 占領戦後史研究会 尚美学園大学総合政策学部

出版者

尚美学園大学総合政策学部総合政策学会

雑誌

尚美学園大学総合政策論集 (ISSN:13497049)

巻号頁・発行日

no.13, pp.87-159, 2011-12

著者

Michihiro KOHGUCHI Shin-ichiro INOUE Shimpei USHIO Kanso IWAKI Masao IKEDA Masashi KURIMOTO

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.10, no.4, pp.420-423, 2007-11-25 (Released:2008-08-28)

参考文献数

27

被引用文献数

9 14

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To investigate the long-term effect of feeding royal jelly (RJ) on the testicular function, 32-week old male golden hamsters were fed diet containing RJ at doses of 0 μg/g diet (control), 50 μg/g diet or 500 μg/g diet for 12 weeks. At the end of the experiment, the hamsters were assessed for testicular function in terms of the amounts of intra-testicular free testosterone (TS) and histopathological changes. RJ diet groups showed higher TS levels and more intensive spermatogenesis than the control group in a dose-dependent manner. The intensity of spermatogenesis and TS levels in the 500 μg of RJ/g diet group showed significant differences of p < 0.01 and p < 0.05, respectively, when compared with those in the control group. These results indicate that the long-term feeding of RJ inhibits the age-associated decline in the testicular function of male hamsters.

著者

Satoshi Kurisu Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Takaki Hata Yasuharu Nakama Yasufumi Kijima Eisuke Kagawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.45, no.10, pp.703-704, 2006 (Released:2006-06-15)

被引用文献数

6 5