- 著者
- TSUNEHIRO ISHIDA NORITAKA SUGAMATA YOSHIKI TAKAI JUN HORIGUCHI YUKIKO KOIBUCHI TAKAO YOKOE YUICHI IINO YASUO MORISHITA TETSUNARI OYAMA TAKASHI JOSHITA
- 出版者
- The Kitakanto Medical Society
- 雑誌
- The KITAKANTO Medical Journal (ISSN:00231908)
- 巻号頁・発行日
- vol.43, no.5, pp.519-524, 1993-09-01 (Released:2009-10-21)
- 参考文献数
- 16
甲状腺癌術前診断における穿刺吸引細胞診の有用性を検討した.1975年から1992年間に穿刺吸引細胞診を施行し, 病理組織診断が判明した結節性甲状腺腫1,540例 (甲状腺癌580例, 良性腫瘍943例, 橋本病17例) を対象とした.穿刺吸引細胞診の診断能は, sensitivity 85%, specificity 93%, accuracy 90%であった.甲状腺癌では乳頭癌の正診率が90%と高く, 濾胞癌で60%と不良であった.1.0cm以下以下の微小癌にも高い正診率 (89%) が得られた.良性腫瘍の正診率は高いが, 橋本病で偽陽性が多くみられた.甲状腺癌の各種診断法の正診率を比較すると, 穿刺吸引細胞診は触診法や超音波検査に比べ良好な成績であった.以上, 穿刺吸引細胞診は甲状腺結節の良悪性診断のみならず, 組織型の推定, 微小癌の診断に有用かつ信頼度が高く, 初診時の必須検査法とすべきである.
- 著者
- Motohide Furuya Tsuyoshi Miyaoka Sadayuki Hashioka Rei Wake Keiko Tsuchie Jun Horiguchi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.44, pp.34-41, 2014-12-30 (Released:2017-06-01)
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.
- 著者
- Rei Wake Tsuyoshi Miyaoka Kazunori Kawakami Motohide Furuya Masa Ieda Liaury Kristian Keiko Tsuchie Akira Nishida Takuji Inagaki Jun Horiguchi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.36, pp.4-17, 2011-03-30 (Released:2017-06-01)
- 参考文献数
- 39
Objective: We attempted to identify the locus of cerebral blood flow reduction to clarify the functional neuroanatomical basis of the first-episode schizophrenia. A secondary objective was to evaluate the diagnostic value a new analytical program, easy Z-score Imaging System (eZIS). Method: We performed single photon emission computed tomography (SPECT) with 99-Tc-ethyl cysteinate dimmer (^<99m>Tc-ECD) of the brains of patients with the first-episode schizophrenia (n=30) and normal controls (n=37) and evaluated the diagnostic value of brain perfusion SPECT using eZIS on patients with schizophrenia. Result: In comparison with normal controls, the patients with schizophrenia were found to have reduced blood flow in bilateral frontal and temporal areas. Conclusion: In our study, patients with the first-episode schizophrenia appeared to have significant bilateral fronto-temporal hypoperfusion. Demonstration of abnormality of frontal and temporal lobe blood flow may assist in the diagnosis of schizophrenia and determination of appropriate treatment for individuals with schizophrenia.
- 著者
- Hideya Yamamoto Norihiko Ohashi Ken Ishibashi Hiroto Utsunomiya Eiji Kunita Toshiharu Oka Jun Horiguchi Yasuki Kihara
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.75, no.10, pp.2424-2431, 2011 (Released:2011-09-22)
- 参考文献数
- 28
- 被引用文献数
- 36 36
Background: Although the coronary artery calcium (CAC) score as measured with computed tomography (CT) is associated with cardiovascular mortality and morbidity in Western countries, little is known in Asian populations. Methods and Results: Three hundred and seventeen Japanese patients (205 men and 112 women) were followed in the study and they underwent both coronary angiography and CT for CAC measurements. The frequencies of angiographic coronary artery disease (CAD) were 5%, 36%, 76%, 80%, and 94% (P<0.001) and the needs for revascularization were 5%, 26%, 53%, 59%, and 69% (P<0.001) in patients with CAC scores of 0 (n=64), 1-100 (n=58), 101-400 (n=76), 401-1,000 (n=70), and >1,000 (n=49), respectively. In the average of 6.0 (range, 1-10) years follow-up period, 34 patients died including 13 from reasons of cardiac disease. In a Cox proportional hazard model after adjustment for age and sex, traditional coronary risk factors, previous myocardial infarction, and the need for revascularization, the hazard ratio for cardiac mortality in patients with a CAC score >1,000 was 2.98 (95% confidence interval: 1.15-9.40) compared with those with a CAC score=0-100. Conclusions: The CAC score has a predictive value for angiographical CAD and long-term mortality from cardiac disease in Japanese high-risk patients who undergo coronary angiography. (Circ J 2011; 75: 2424-2431)