著者

Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.73, no.2, pp.161-171, 2023 (Released:2023-09-01)

参考文献数

51

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Metabolic differences between colorectal cancer (CRC) and NI (NI) play an important role in early diagnoses and in-time treatments. We investigated the metabolic alterations between CRC patients and NI, and identified some potential biomarkers, and these biomarkers might be used as indicators for diagnosis of CRC. In this study, there were 79 NI, 50 CRC I patients, 52 CRC II patients, 56 CRC III patients, and 52 CRC IV patients. MS-MS was used to measure the metabolic alterations. Univariate and multivariate data analysis and metabolic pathway analysis were applied to analyze metabolic data and determine differential metabolites. These indicators revealed that amino acid and fatty acids could separate these groups. Several metabolites indicated an excellent variables capability in the separation of CRC patients and NI. Ornithine, arginine, octadecanoyl carnitine, palmitoyl carnitine, adipoyl carnitine, and butyryl carnitine/propanoyl carnitine were selected to distinguish the CRC patients and NI. And methionine and propanoyl carnitine, were directly linked to different stages of CRC. Receiver operating characteristics curves and variables importance in projection both represented an excellent performance of these metabolites. In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.

著者

XUEKUN YANG JING BAI HISAMASA IMAI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.3, pp.240-247, 2016 (Released:2016-11-02)

参考文献数

17

被引用文献数

1 2

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Objective: We aimed to reveal the declining status of autopsy rate in Japanese university hospitals during the last 34-year period, to draw attention to the importance of autopsy.Methods: Autopsy related data from 1979 to 2012 in all Japanese university hospitals were collected and analyzed on annual basis under categories of Juntendo University Hospital, Japanese university hospitals, public university hospitals and private university hospitals separately. Trends of changes in autopsy rate from 1979 to 2012 were plotted and compared between the groups.Results: The autopsy rate in Juntendo University Hospital was maintained at the levels of 50-60% until 1986, then started to decline steadily and reached to 9.7% in 2012. Regression coefficient of the autopsy rate during the 34-year period was -0.0173. The mean autopsy rate of all university hospitals in Japan was maintained at 45% until 1983, then started declining steadily and reached to 6.8% in 2012. Of these hospitals, the mean autopsy rate in public hospitals was still kept at 45% in 1985 but continued declining to 9.3% in 2012, while in private hospitals it reached to 45% in 1983 and kept declining to only 5.6% in 2012.Conclusion: The steady decline of the autopsy rate in university hospitals in Japan began early 1980’; this trend still continues, and the autopsy rate declined to 6.8% in 2012. We should work to prevent the decline of autopsy rate furthermore in Japanese university hospitals.