著者

Han Lin Feng Zhang Kun Wu Jing Xu

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.87-93, 2019 (Released:2019-05-14)

参考文献数

35

被引用文献数

5

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Five δ-two-stream and δ-four-stream schemes are compared in solar spectra using the Rapid Radiative Transfer Model for General Circulation Models Applications (RRTMG). By calculating the flux and heating rate in various atmosphere, it is found that, in accuracy, the δ-four-stream schemes overwhelmingly outperform the δ-two-stream schemes. The precision of adding algorithm of the δ-four-stream spherical harmonic expansion (δ-4SDA) is comparable to that of adding algorithm of the δ-four-stream discrete ordinates method (δ-4DDA). Furthermore, the accuracy of the adding algorithm of δ-Eddington approximation (δ-2SDA) is close to that of δ-two-stream approximation with Practical Improved Flux Method (δ-PIFM), while adding algorithm of δ-two-stream discrete ordinates method (δ-2DDA) produces the poorest results among the five approximate schemes. For the RRTMG model with radiative transfer calculation, the computational time of δ-4SDA is about 1.5 times that of δ-two-stream schemes, and the computational time of δ-4SDA is about 88% that of δ-4DDA.

著者

Abdul Razaq HIRMAN Lili DU Shaohang CHENG Heng ZHENG Linna DUO Qianyu ZHAI Jing XU

出版者

Japanese Association for Laboratory Animal Science

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

pp.20-0159, (Released:2021-03-03)

被引用文献数

3

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Excessive scar formation post burn injury can cause great pain to the patients. MiR-133a-3p has been demonstrated to be anti-fibrotic in some fibrosis-related diseases. However, its possible role in scar formation has not been elucidated yet. In present study, the effect of miR-133a-3p on scar formation was investigated in a scalded model of mice. Moreover, the function of miR-133a-3p on proliferation and migration of scar-derived fibroblasts (SFs) was studied in vitro. It was found that miR-133a-3p was dramatically downregulated in scar tissue of scalded mice. Upregulation of miR-133a-3p by miR-133a-3p agomir obviously inhibited the scar formation in scalded mice. Histological staining showed that upregulation of miR-133a-3p attenuated the excessive deposition of collagen in scar tissue of scalded mice. In vitro study showed that upregulation of miR-133a-3p effectively suppressed the proliferation and migration of SFs. Besides, upregulation of miR-133a-3p attenuated the protein levels of α-smooth muscle actin (α-SMA) and collagen I, indicating that miR-133a-3p could suppress the activation of SFs. The expression of connective tissue growth factor (CTGF), a critical mediator in cell proliferation, migration and extracellular matrix (ECM) synthesis, was also downregulated by the upregulation of miR-133a-3p. Luciferase reporter assay validated that CTGF was directly targeted by miR-133a-3p. In addition, overexpression of CTGF abolished the effect of miR-133a-3p on inhibiting the proliferation, migration and activation of SFs, indicating that miR-133a-3p functioned by targeting CTGF. Therefore, miR-133a-3p might be a promising target for treating pathological scars.

著者

Jing XU Yuqing WANG

出版者

Meteorological Society of Japan

雑誌

Journal of the Meteorological Society of Japan. Ser. II (ISSN:00261165)

巻号頁・発行日

pp.2018-014, (Released:2017-12-26)

被引用文献数

29

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The dependence of intensification rate (IR) of a tropical cyclone (TC) on its initial structure, including the radius of maximum wind (RMW) and the radial decay rate of tangential wind outside the RMW, is examined based on ensemble of simulations using a nonhydrostatic axisymmetric cloud-resolving model. It is shown that the initial spinup period is shorter and the subsequent IR is larger for the storm with the initially smaller RMW or with the initially more rapid radial decay of tangential wind outside the RMW. The results show that the longevity of the initial spinup period is determined by how quickly the inner-core region becomes nearly saturated in the middle and lower troposphere and thus deep convection near the RMW is initiated and organized. Because of the larger volume and weaker Ekman pumping, the inner-core of the initially larger vortex takes longer time to become saturated and thus experiences a longer initial spinup period. The vortex initially with the larger RMW (with the slower radial decay of tangential wind outside the RMW) has lower inertial stability inside the RMW (higher inertial stability outside the RMW) develops more active convection in the outer-core region and weaker boundary-layer inflow in the inner-core region and thus experiences lower IR during the primary intensification stage.