文献一覧: Jun Liu (著者) - Ceek.jp Altmetrics

5 0 0 0 OA Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

著者: Shen Gao Dong Zhao Yue Qi Wei Wang Miao Wang Jiayi Sun Jun Liu Yan Li Jing Liu
出版者: Japan Atherosclerosis Society
雑誌: Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日: pp.43299, (Released:2018-03-07)
参考文献数: 34
被引用文献数: 17

Aims: To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis and to examine whether this link is independent of other low-density lipoprotein (LDL)-related parameters.Methods: Totally, 804 subjects who were free of cardiovascular disease at baseline completed risk factor surveys and carotid ultrasound measurements in 2002 and 2012. Modified Poisson regression was performed to examine the association between baseline serum ox-LDL levels and the 10-year risk of progression of carotid atherosclerosis which was defined as the development of at least one new plaque in a previously plaque-free carotid segment at re-examination.Results: The mean age of the subjects was 58.6±7.7 years at baseline and 43.3% were men. A total of 504 (62.7%) subjects had carotid plaque progression at re-examination. Subjects in the intermediate and highest tertiles of ox-LDL had a significantly higher adjusted risk of atherosclerosis progression than those in the lowest tertile [relative risk (95% confidence interval) 1.17 (1.01–1.34) for the intermediate tertile and 1.23 (1.07–1.42) for the highest tertile]. This association was independent of baseline levels of LDL-C, total LDL particle number, and small LDL particle number.Conclusion: This study demonstrates that serum ox-LDL levels predict 10-year progression of subclinical atherosclerosis. Moreover, this effect is independent of the cholesterol content, the number, and the size of LDL particles.

2018-06-30 23:38:25
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3 0 0 0 OA Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

著者: Shen Gao Dong Zhao Yue Qi Wei Wang Miao Wang Jiayi Sun Jun Liu Yan Li Jing Liu
出版者: Japan Atherosclerosis Society
雑誌: Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日: vol.25, no.10, pp.1032-1043, 2018-10-01 (Released:2018-10-01)
参考文献数: 34
被引用文献数: 7 17

2020-11-03 20:00:36
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1 0 0 0 OA Cytomegalovirus viremia is associated with poor outcomes in AIDS patients with disseminated nontuberculous mycobacterial disease

著者: Bo Tian Jianjun Sun Jinsong Bai Renfang Zhang Jun Liu Yinzhong Shen Chongxi Li Li Liu Jun Chen Tangkai Qi Hongzhou Lu
出版者: International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌: BioScience Trends (ISSN:18817815)
巻号頁・発行日: pp.2021.01279, (Released:2021-09-29)
参考文献数: 31

Both cytomegalovirus (CMV) viremia and disseminated nontuberculous mycobacterial (NTM) disease are common opportunistic infections in AIDS patients. Whether concurrent CMV viremia is associated with mortality in patients with AIDS and disseminated NTM disease is unknown. Subjects were patients with AIDS and disseminated NTM disease seen at a single center from January 2015 to April 2021. Data were retrospectively collected. Differences in demographics and clinical characteristics and hospitalization survival rates were compared between patients with disseminated NTM and with CMV viremia or not. Subjects were 113 AIDS patients with disseminated NTM who were seen at this Hospital from January 2015 to April 2021. Twenty-six of the patients had CMV viremia and 87 did not. The median age was 36 years (interquartile range [IQR] 29-42) and 108 patients were male (96%). The median CD4 count was 7 cells/µL (IQR 3-17). The median plasma CMV viral load was 9,245 IU/mL (IQR 3147-45725). The serum albumin of patients with CMV viremia was significantly lower than that of patients without CMV viremia (P = 0.03). Compared to patients without CMV viremia (81.6%), patients with CMV viremia had a significantly poorer prognosis (P = 0.01). Cox regression analysis indicated that the risk of a poor prognosis in patients with CMV viremia was 4.7 times higher than that in patients without CMV viremia (P = 0.003), and patients with CD8 more than 250/μL had a better prognosis (P = 0.02). CMV viremia increases the risk of a poor prognosis in patients with AIDS and a disseminated NTM infection. A routine CMV DNA test should be performed on patients with AIDS and disseminated NTM disease in order to reduce the risk of death.

2021-10-03 06:52:40
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1 0 0 0 OA An Evaluation of Darknet Traffic Taxonomy

著者: Jun Liu Kensuke Fukuda
出版者: Information Processing Society of Japan
雑誌: Journal of Information Processing (ISSN:18826652)
巻号頁・発行日: vol.26, pp.148-157, 2018 (Released:2018-02-15)
参考文献数: 35
被引用文献数: 1

To enhance Internet security, researchers have largely emphasized diverse cyberspace monitoring approaches to observe cyber attacks and anomalies. Among them darknet provides an effective passive monitoring one. Darknets refer to the globally routable but still unused IP address spaces. They are often used to monitor unexpected incoming network traffic, and serve as an effective network traffic measurement approach for viewing certain remote network security activities. Previous works in this field discussed possible causes (i.e., anomalies) of darknet traffic and applied their classification schemes on short-term traces. Our interest lies, however, in how darknet traffic has evolved and the effectiveness of a darknet traffic taxonomy for longitudinal data. To reach these goals, we propose a simple darknet traffic taxonomy based on network traffic rules, and evaluate it with two darknet traces: one covering 12 years since 2006, while the other covering 11 years since 2007. The evaluation results reveal the effectiveness of this taxonomy: we are able to label over 94% of all source IPs with anomalies defined by the taxonomy, leaving the unlabeled source ratio low. We also examine the evolution of different anomalies since 2006 (especially in recent years), analyze the temporal and spatial dependency and parameter dependency of darknet traffic, and conclude that most sources in the datasets are characterized by just one or two anamalies with simple attack mechanisms. Moreover, we compare the taxonomy with a one-way traffic analysis tool (i.e., iatmon) to better understand their differences.

2018-02-21 19:22:27
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