著者

Yoshimi KISHIMOTO Chie TAGUCHI Norie SUZUKI-SUGIHARA Emi SAITA Mika USUDA Wei WANG Yasunobu MASUDA Kazuo KONDO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.62, no.5, pp.361-365, 2016 (Released:2016-12-06)

参考文献数

26

被引用文献数

2 18

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The egg is a nutrient-dense food and contains a number of antioxidants. The consumption of eggs has been considered to improve the balance of diets, although its impact on serum cholesterol levels has been a matter of concern in many countries. Here, we conducted a pilot study to investigate whether daily additional consumption of an egg might affect serum lipid profiles and also antioxidant status in healthy subjects. Fourteen male subjects were provided with breakfasts including a boiled egg for 4 wk. At the end of intervention, serum concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were unchanged, despite the significant increase in the intake of dietary cholesterol. In contrast, a significant increase in high-density lipoprotein cholesterol (HDL-C) and a reduction of the LDL-C/HDL-C ratio were observed. Interestingly, the malondialdehyde modified-LDL (MDA-LDL)/LDL-C ratio and the oxidizability of LDL were significantly reduced. Serum total antioxidant capacity value after the intervention period was higher than at baseline. These data indicate that consuming one egg per day for 4 wk as breakfast in addition to a normal diet does not affect serum lipids, and suggests that it may improve serum antioxidant status in healthy males.

著者

Shen Gao Dong Zhao Yue Qi Wei Wang Miao Wang Jiayi Sun Jun Liu Yan Li Jing Liu

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.43299, (Released:2018-03-07)

参考文献数

34

被引用文献数

18

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Aims: To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis and to examine whether this link is independent of other low-density lipoprotein (LDL)-related parameters.Methods: Totally, 804 subjects who were free of cardiovascular disease at baseline completed risk factor surveys and carotid ultrasound measurements in 2002 and 2012. Modified Poisson regression was performed to examine the association between baseline serum ox-LDL levels and the 10-year risk of progression of carotid atherosclerosis which was defined as the development of at least one new plaque in a previously plaque-free carotid segment at re-examination.Results: The mean age of the subjects was 58.6±7.7 years at baseline and 43.3% were men. A total of 504 (62.7%) subjects had carotid plaque progression at re-examination. Subjects in the intermediate and highest tertiles of ox-LDL had a significantly higher adjusted risk of atherosclerosis progression than those in the lowest tertile [relative risk (95% confidence interval) 1.17 (1.01–1.34) for the intermediate tertile and 1.23 (1.07–1.42) for the highest tertile]. This association was independent of baseline levels of LDL-C, total LDL particle number, and small LDL particle number.Conclusion: This study demonstrates that serum ox-LDL levels predict 10-year progression of subclinical atherosclerosis. Moreover, this effect is independent of the cholesterol content, the number, and the size of LDL particles.

著者

Shen Gao Dong Zhao Yue Qi Wei Wang Miao Wang Jiayi Sun Jun Liu Yan Li Jing Liu

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.25, no.10, pp.1032-1043, 2018-10-01 (Released:2018-10-01)

参考文献数

34

被引用文献数

7 18

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Aims: To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis and to examine whether this link is independent of other low-density lipoprotein (LDL)-related parameters.Methods: Totally, 804 subjects who were free of cardiovascular disease at baseline completed risk factor surveys and carotid ultrasound measurements in 2002 and 2012. Modified Poisson regression was performed to examine the association between baseline serum ox-LDL levels and the 10-year risk of progression of carotid atherosclerosis which was defined as the development of at least one new plaque in a previously plaque-free carotid segment at re-examination.Results: The mean age of the subjects was 58.6±7.7 years at baseline and 43.3% were men. A total of 504 (62.7%) subjects had carotid plaque progression at re-examination. Subjects in the intermediate and highest tertiles of ox-LDL had a significantly higher adjusted risk of atherosclerosis progression than those in the lowest tertile [relative risk (95% confidence interval) 1.17 (1.01–1.34) for the intermediate tertile and 1.23 (1.07–1.42) for the highest tertile]. This association was independent of baseline levels of LDL-C, total LDL particle number, and small LDL particle number.Conclusion: This study demonstrates that serum ox-LDL levels predict 10-year progression of subclinical atherosclerosis. Moreover, this effect is independent of the cholesterol content, the number, and the size of LDL particles.

著者

Emile Mehanna Hiram G. Bezerra David Prabhu Eric Brandt Daniel Chamié Hirosada Yamamoto Guilherme F. Attizzani Satoko Tahara Nienke Van Ditzhuijzen Yusuke Fujino Tomoaki Kanaya Gregory Stefano Wei Wang Madhusudhana Gargesha David Wilson Marco A. Costa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.9, pp.2334-2340, 2013 (Released:2013-08-23)

参考文献数

23

被引用文献数

15 67

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Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy of intravascular FD-OCT to determine the distribution of CAC. Methods and Results: Cadaveric coronary arteries were imaged using FD-OCT at 100-μm frame interval. Arteries were subsequently frozen, sectioned and imaged at 20-μm intervals using the Case Cryo-Imaging automated systemTM. Full volumetric co-registration between FD-OCT and cryo-imaging was performed. Calcium area, calcium-lumen distance (depth) and calcium angle were traced on every cross-section; volumetric quantification was performed offline. In total, 30 left anterior descending arteries were imaged: 13 vessels had a total of 55 plaques with calcification by cryo-imaging; FD-OCT identified 47 (85%) of these plaques. A total of 1,285 cryo-images were analyzed and compared with corresponding co-registered 257 FD-OCT images. Calcium distribution, represented by the mean depth and the mean calcium angle, was similar, with excellent correlation between FD-OCT and cryo-imaging respectively (mean depth: 0.25±0.09 vs. 0.26±0.12mm, P=0.742; R=0.90), (mean angle: 35.33±21.86° vs. 39.68±26.61°, P=0.207; R=0.90). Calcium volume was underestimated in large calcifications (3.11±2.14 vs. 4.58±3.39mm3, P=0.001) in OCT vs. cryo respectively. Conclusions: Intravascular FD-OCT can accurately characterize CAC distribution. OCT can quantify absolute calcium volume, but may underestimate calcium burden in large plaques with poorly defined abluminal borders.  (Circ J 2013; 77: 2334–2340)

著者

Ngoc Kien Bui Ryo Kurihara Wei Wang Manabu Kanematsu Hikotsugu Hyodo Miku Takano Hiroshi Hirao Takafumi Noguchi Ippei Maruyama

出版者

Japan Concrete Institute

雑誌

Journal of Advanced Concrete Technology (ISSN:13473913)

巻号頁・発行日

vol.21, no.3, pp.166-188, 2023-03-30 (Released:2023-03-30)

参考文献数

105

被引用文献数

1

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This study investigates the wet carbonation of concrete fines with CO2 and natural air gas bubbling in a carbonation system at low temperatures. After the air- and CO2-wet carbonations, the properties of a solution and hydrated cement paste powder are determined. In the air and CO2-wet carbonations, more Ca is extracted into the solution at a low temperature of 5°C. This high Ca concentration in the solution through air-wet carbonation primarily originates from the portlandite and unhydrated phases of the cement paste. Even in solutions with high pH values, the rehydration process and C–S–H decomposition occur simultaneously in air-wet carbonation. Moreover, CO2-wet carbonation indicates that the decalcification of C–S–H occurs rapidly, even in the presence of portlandite. Air-wet carbonation presents a potential method for the direct air capture of CO2 using concrete waste fines in a short period.

著者

Yan Qing JIA Xiang Wei WANG Xi CHEN Xin Xin QIU Xing Long WANG Zeng Qi YANG

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.3, pp.473-483, 2022 (Released:2022-03-30)

参考文献数

30

被引用文献数

5

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Interferon-induced protein-35 kDa (IFI35) was an antiviral protein induced by interferon (IFN)-γ, which plays an important role in the IFN-mediated antiviral signaling pathway. Here, we cloned and identified IFI35 in the chicken for the first time. Chicken IFI35 (chIFI35) contains an open reading frame (ORF) of 1,152 bp encoding a protein of 384 amino acids containing two conserved Nmi/IFI35 domain (NID) motifs. Tissue distribution analysis of chIFI35 in healthy and Newcastle disease (ND) virus-infected chickens indicated a positive correlation between chIFI35 mRNA transcription and ND viral loads in various tissues. The role of chIFI35 in regulation NDV replication were further assessed by up- or down-regulated chIFI35 expression in DF-1 cells transfected with plasmid harboring chIFI35, pCMV-3HA-chIFI35 or shRNA targeting chIFI35, pshRNA-chIFI35 plasmids. NDV replications in DF-1 cells were significantly reduced or slightly increased by over- or under-expression of the chIFI35 protein, respectively, indicating the role of chIFI35 in anti-NDV infection. Moreover, chIFI35 also involved in regulation of viral gene transcription and IFNs expression. The collected data were meaningful for research of chicken antiviral immunity and shed light on the pleiotropic antiviral effect of chIFI35 during NDV infection.

著者

Wei WANG Shaozhong LUO Yaping CHEN Bo LI Masao HATTORI

出版者

(社)日本分析化学会

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.32, no.6, pp.705-707, 2016-06-10 (Released:2016-06-10)

参考文献数

15

被引用文献数

7

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An effective separation and simultaneous determination of corynoxeine and its metabolites using high-performance liquid chromatography with tandem mass spectrometry was developed and validated. The method was applied to pharmacokinetics and in vivo distribution investigations in rats after oral (0.105 mmol kg−1) and intravenous (0.0105 mmol kg−1) doses of corynoxeine. Its brain uptake index was of 3.08 × 10−11 mol g−1 at 3 h and 3.75 × 10−11 mol g−1 at 74 min after oral and intravenous doses, respectively.

著者

Bao-Wei Wang Guo-Qing Huang Wei-Wei Wang Wen-Hua Ge Ming-Ai Zhang

出版者

日本家禽学会

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

pp.0120090, (Released:2012-11-25)

被引用文献数

2

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The beneficial effects of dietary selenium (Se) supplementation for poultry and the distribution of Se in tissues have been well documented, but the functionalities of the Se-enriched products are much less concerned. Alcohol induces liver injury by initiating oxidative stress and antioxidant therapy has been proposed as an effective way of reducing the injury. Because a correlation between Se and antioxidant capability has been established, the alleviation effect of the Se-enriched fatty goose liver (SFGL, containing 900 μg/kg Se) on alcohol-induced liver injury was studied. Mice were daily fed with 2.5, 5, and 10 g/kg·bw SFGL and common fatty goose liver (CFGL, containing 200 μg/kg Se) one hour after ethanol administration and the animals were scarified and the blood and liver were collected for analysis on day 21. Results indicated that SFGL was more effective in reducing the hepatosomatic index and the degree of steatosis than CFGL. SFGL in all the three doses normalized the lipid metabolism and the activities of ALT and AST, indicating that SFGL attenuated the alcohol-induced liver injury. SFGL decreased the serum and hepatic ADH activities and the MDA content, implying that the liver injury attenuation effect of SGFL was related to oxidative stress reduction. The measurement of antioxidant variables, including GSH-Px, GSH, and SOD, revealed that the levels of these molecules were significantly increased after SFGL ingestion, confirming that SFGL alleviated alcohol-induced liver injury by enhancing the antioxidant capability. It was concluded that Se-enriched poultry tissues are potential remediators against alcohol-induced liver injury.