著者

Jing Lin Jun Zhu Yan Wang Na Zhang Hans-Jürgen Gober Xuemin Qiu Dajin Li Ling Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

vol.11, no.5, pp.496-506, 2017-10-31 (Released:2017-11-20)

参考文献数

99

被引用文献数

19 60

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Postmenopausal osteoporosis is a systemic metabolic skeletal disease generally ascribable to a dearth of estrogen. Whether traditional Chinese medicine is effective in management of postmenopausal osteoporosis remains unclear. This article reviews the experimental evidence of both in vitro and in vivo preclinical studies with the theme of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis. It includes three single herbs (Herba Epimedium, Rhizoma Drynariae, and Salvia miltiorrhiza) and eight active ingredients (saikosaponins, linarin, echinacoside, sweroside, psoralen, poncirin, vanillic acid, and osthole). The experimental studies indicated their potential use as treatment for postmenopausal osteoporosis and investigated the underlying mechanisms including osteoprotegerin/receptor activator of nuclear factor κB ligand (OPG/RANKL), extracellular-signal-regulated kinase/c-Jun N terminal kinase/mitogen-activated protein kinase (ERK/JNK/MAPK), estrogen receptor (ER), bone morphogenetic protein (BMP), transforming growth factor (TGF)-β, Wnt/β-catenin, and Notch signaling pathways. This review contributes to a better understanding of traditional Chinese medicine and provides useful information for the development of more effective anti-osteoporosis drugs.

著者

TAKENORI INOMATA JAEMYOUNG SUNG MASAHIRO NAKAMURA MASAO IWAGAMI YUICHI OKUMURA KENTA FUJIO YASUTSUGU AKASAKI KEIICHI FUJIMOTO AI YANAGAWA AKIE MIDORIKAWA-INOMATA KEN NAGINO ATSUKO EGUCHI HURRRAMHON SHOKIROVA JUN ZHU MARIA MIURA MIZU KUWAHARA KUNIHIKO HIROSAWA TIANXING HUANG YUKI MOROOKA AKIRA MURAKAMI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.67, no.6, pp.519-529, 2021 (Released:2021-12-31)

参考文献数

67

被引用文献数

9

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Society 5.0, a visionary human-centered societal model, fuels economic development and resolves long-standing social problems. The model establishes a technological foundation and social contract to integrate cyberspace into the physical (real) space fully. The medical infrastructure outlined by the model envisions a healthcare paradigm that revolves around preventative, lifelong patient- and population- centered care that functions seamlessly within one's daily life. In satisfying this goal, cross-hierarchical integrative data-driven biological research has received attention due to medical big data and artificial intelligence (AI) technologies, capable of highly accurate and rapid data analysis. However, the collection of big data has been a bottleneck, and the capability of AI analysis is not being utilized to its full potential. In solving this obstacle, we explore mobile health (mHealth) and multi-omics as two rich sources of medical big data. Additionally, we discuss the implications of cross-hierarchical integrative analysis that encompasses all levels of cellular function, from intracellular molecular dynamics to end-phenotypes. This is to understand ocular disease pathology and implement the pillars of P4 (predictive, personalized, preventative, participatory) medicine toward human-centered healthcare. Here, we discuss notable studies in utilizing mHealth to stratify subjective symptoms, presentations of dry eye disease, and employing multi-omics machine learning targeted at elucidating immunologic mechanisms of corneal allograft rejection and ocular inflammation. We also discuss the role of cross-hierarchical integrative data-driven research in promoting future-oriented healthcare envisioned by the Society 5.0 plan.

著者

Yan Du Jing Lin Likun Lan Ying Dong Jun Zhu Wen Jiang Xinyao Pan Youhui Lu Dajin Li Ling Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2018.01044, (Released:2018-06-28)

参考文献数

21

被引用文献数

4

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Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In the current study, we aimed to evaluate the clinical application and compare test outcomes of two generations of currently used NIPT techniques for detecting fetal chromosome abnormalities in a high-risk prenatal population. A total of 7,252 pregnant women were included from twenty-one hospitals from January 2015 to September 2017. A maternal blood sample of each participant was collected for fetal DNA sequencing. Group I received a first generation NIPT sequencing technique to detect chromosome aneuploidies, and Group II received a second generation NIPT sequencing technique to detect subchromosome abnormalities. An abnormal NIPT result was reported in 0.90% (44/4,868) of the women in Group I and 2.68% (64/2,384) in Group II. In Group I, seventeen (17/37, 45.95%) women with suspected fetal aneuploidy received amniocentesis, which confirmed 100% (10/10) of positive trisomy 21 samples, 100% (1/1) of trisomy 18, 100% (1/1) of sex chromosome abnormality, 0% (0/2) of trisomy 16, 0% (0/2) of trisomy 13, and 0% (0/1) of trisomy 20 and 13. In Group II, aneuploidy accounted for 46.88% (30/64) of the abnormal results. Five underwent amniocentesis and three had an abnormal result, including two cases of trisomy 21 and one case of chromosome 5p deletion syndrome. Whereas one case of 46,XN,del(16q11.2-q22.3) and another case of 46,XN,dup(Xp22.31) were considered as normal. NIPT is a quick and reliable screening method for detecting fetal chromosome aneuploidies and subchromosome deletions/duplications. Challenges remain for the comprehensive clinical application of NIPT.

著者

Yong-Biao ZHANG Ji-Dang CHEN Jie-Xiong XIE Wan-Jun ZHU Chun-Ya WEI Li-Kai TAN Nan CAO Ye CHEN Min-Ze ZHANG Gui-Hong ZHANG Shou-Jun LI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0022, (Released:2013-03-15)

被引用文献数

5 10

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Reports of dogs with H3N2 canine influenza virus (CIV) have been documented frequently. To better understand the seroprevalence of H3N2 CIV among dogs in northeast China, here we report for the first time a relatively high seroprevalence of H3N2 CIV infection in dogs in northeast China. Forty-five of the 223 canine sera (20.2%) and 166 of the 500 canine sera (33.2%) tested feral dogs and pet dogs were seropositive by NP-ELISA, which is higher than that in southern China. The relative data provided in this report can be useful for small animal practitioners or public health policy makers to carry out relative measures for the prevention of this disease. Meanwhile similar seroprevalence studies and prospective natural history and incidence studies should also be undertaken in other places.