著者

Hirotoshi UTSUNOMIYA Tadashi YAMAKAWA Junzo KAMEI Kazuaki KADONOSONO Shun-Ichi TANAKA

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.26, no.5, pp.193-200, 2005 (Released:2005-12-05)

参考文献数

30

被引用文献数

11 24

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Dried plums, considered a healthy food in the West and used as medicine in India, contain phenolic compounds with protective actions against age-related diseases. Effects of oral plum ekisu (concentrated juice) on lipid and glucose tolerance were assessed in insulin-resistant obese Wistar fatty rats. Plum ingestion decreased blood glucose (P < 0.05) and plasma triglyceride concentrations (P < 0.01) compared with controls. Plum treatment for 2 weeks reduced areas under the curve (AUCs) for glucose and insulin during a glucose tolerance test. In db/db mice, plum decreased these AUCs, and also blood glucose during an insulin tolerance test. Plum treatment significantly increased plasma adiponectin concentrations and PPARγ mRNA expression in adipose tissue from Wistar fatty rats. Plum thus may increase insulin sensitivity in these rats via adiponectin-related mechanisms.

著者

Jun Suzuki Tadashi Yamakawa Mari Oba Jo Nagakura Erina Shigematsu Haruka Tamura Kenichiro Takahashi Yoshihisa Okamoto Rika Sakamoto Minori Shinoda Tatsuro Takano Kazuaki Kadonosono Yasuo Terauchi

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.66, no.11, pp.971-982, 2019 (Released:2019-11-28)

参考文献数

43

被引用文献数

11

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The short-term efficacy and safety of insulin degludec U100 (IDeg) in patients with type 2 diabetes have not been reported widely. We compared insulin IDeg and insulin glargine U100 (IGla) for glycemic control and glucose variability in hospitalized patients with type 2 diabetes. In an open-label, multicenter, randomized controlled trial, 74 patients were randomly assigned to either the IDeg (36 patients) or IGla (38 patients) group and were administered with basal-bolus therapy during hospitalization. Following the start of the treatment, on day 11, glucose variability was assessed by continuous glucose monitoring. A fasting blood glucose level of 110 mg/dL and 2-hour postprandial blood glucose level of 180 mg/dL throughout at least one day during the observation period were achieved in 31.3% (10/32) and 30.6% (11/36) of the patients in the IDeg and IGla groups, respectively. The 6-point self-monitoring of blood glucose profiles showed a significant difference between the two groups. On day 7, the intra-day variation was larger in the IDeg group than in the IGla group. The incidence of hypoglycemia or glucose variability was comparable in the two groups. This study suggests that short-term efficacy and safety of IDeg and IGla in patients with type 2 diabetes during the initial phase of basal-bolus therapy were comparable, and these results can help in deciding which treatment to opt for.

著者

山崎 健一朗 和田 浩卓 桜田 伊知郎 門之園 一明 佐伯 宏三 Kenichiro YAMAZAKI Hirotaka WADA Ichiro SAKURADA Kazuaki KADONOSONO Kozo SAEKI 佐伯眼科クリニック 佐伯眼科クリニック 佐伯眼科クリニック 横浜市立大学附属市民総合医療センター眼科 佐伯眼科クリニック Saeki Eye Clinic Saeki Eye Clinic Saeki Eye Clinic Yokohama City University Medical Center Department Of Ophthalmology Saeki Eye Clinic

雑誌

横濱醫學 = The Yokohama medical journal (ISSN:03727726)

巻号頁・発行日

vol.56, no.3, pp.197-200, 2005-05-31

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背景:脈絡膜破裂を伴った外傷性黄斑円孔に対し硝子体手術を行った一例を経験したので報告する.症例と所見:26歳女性,うちあげ花火が直接右眼にあたり鈍的外傷となった.初診時の矯正視力は0.01であり,白内障,前房出血,黄斑円孔,脈絡膜破裂に伴う黄斑下出血と網膜浮腫がみられた.3週間後黄斑円孔は拡大した.6週後の蛍光眼底造影にて黄斑部に及ぶ網膜循環障害を認めた.受傷6週間後にインドシアニングリーンを用いた内境界膜剥離術を行った.黄斑下手術は行わなかった.結果:術後黄斑円孔は閉鎖し,視力は0.5に改善した.重篤な術後合併症は見られなかった.結論:脈絡膜破裂のある外傷性黄斑円孔に対しても硝子体手術は有効であると考えられた.