- 著者
- Kazuyo TUJIOKA Panicha THANAPREEDAWAT Takashi YAMADA Hidehiko YOKOGOSHI Kenji HORIE Mujo KIM Kazumi TSUTSUI Kazutoshi HAYASE
- 出版者
- Center for Academic Publications Japan
- 雑誌
- Journal of Nutritional Science and Vitaminology (ISSN:03014800)
- 巻号頁・発行日
- vol.60, no.1, pp.60-65, 2014 (Released:2014-04-24)
- 参考文献数
- 39
- 被引用文献数
- 1 1
The brain protein synthesis and the plasma concentration of growth hormone (GH) is sensitive to the dietary γ-aminobutyric acid (GABA) in ovariectomized female rats; however, the role of dietary GABA on biomarkers including nerve growth factor (NGF) and choline acetyltransferase for the function of cholinergic neurons remains unknown in ovariectomized female rats. The purpose of this study was to determine whether the dietary GABA affects the concentration and mRNA level of NGF, and the activity of choline acetyltransferase in the brains of ovariectomized female rats. Experiments were done on two groups of 24-wk-old ovariectomized female rats given 0 or 0.5% GABA added to a 20% casein diet. The concentrations of NGF and activities of choline acetyltransferase in the cerebral cortex and hippocampus, and mRNA level of NGF in the hippocampus increased significantly with the 20% casein+0.5% GABA compared with the 20% casein diet alone. In the hippocampus, the mRNA level of NGF significantly correlated with the NGF concentration (r=0.714, p<0.01). These results suggest that the administration of GABA to ovariectomized female rats is likely to control the mRNA level and concentration of NGF and cause an increase in the activity of choline acetyltransferase in the brains.
1 0 0 0 OA 看護マネジメント実習にアクティブ・ラーニングを取り入れた効果
- 著者
- 吾妻 知美 筒井 佳澄 Tomomi Azuma Kazumi Tsutsui
- 出版者
- 京都府立医科大学医学部看護学科
- 雑誌
- 京都府立医科大学看護学科紀要 = Bulletin of School of Nursing Kyoto Prefectural University of Medicine (ISSN:13485962)
- 巻号頁・発行日
- vol.29, pp.21-27, 2019-12-25
京都府立医科大学医学部看護学科