著者

Keisuke Shibata Akihiro Tokushige Yuki Hamamoto Koji Higuchi Masakazu Imamura Yoshiyuki Ikeda Mitsuru Ohishi

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-22-0112, (Released:2023-01-27)

参考文献数

24

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Background: Cancer-associated thrombosis (CAT) is a common complication of cancer and has received increasing attention; the Khorana Risk Score (KRS) is a recommended but insufficient risk assessment model for CAT. We propose a novel Kagoshima-DVT score (KDS) to predict preoperative deep vein thrombosis (DVT). This scoring method scores D-dimer ≥1.5 μg/mL, age ≥60 years, female sex, ongoing glucocorticoids, cancer with high risk of DVT, and prolonged immobility. The purpose of this study was to compare the performance of the KDS and KRS in predicting CAT in patients with gastrointestinal cancer.Methods and Results: In all, 250 patients without a history of thrombosis who received their first chemotherapy for gastrointestinal cancer were divided into low- (48.0%), intermediate- (38.8%), and high-risk (13.2%) groups for CAT development by the KDS. The patients’ median age was 67 years and 63.2% were men. In all, 61 (27.1%) patients developed CAT (17.6%, 35.3%, and 36.4% of patients in the low-, intermediate, and high-risk groups, respectively; log-rank P=0.006). The area under the time-dependent receiver operating characteristic curve for CAT occurrence within 1 year was larger for the KDS than KRS (0.653 vs. 0.494).Conclusions: A high KDS at the start of first chemotherapy is a risk indicator for CAT development during chemotherapy. Moreover, the KDS is more useful than the KRS in predicting CAT risk.

著者

Nobuyasu Tomabechi Kazuki Takizawa Keisuke Shibata Masao Mizuno

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.10, no.4, pp.191-198, 2021-07-25 (Released:2021-07-15)

参考文献数

28

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Work-matched high-intensity intermittent cycling training (HIICT) reportedly improves VO2max regardless of the combination of loads and cadences. However, the effect of work-matched HIICT with different combinations of loads and cadences on anaerobic work capacity is unknown. This study aims to investigate the effects of work-matched HIICT with different loads and cadences on Wingate anaerobic test (WAnT) performance, which is an index of anaerobic work capacity. University athletes performed HIICT either with high-load / 60 rpm (HL60, n = 8) or low-load / 120 rpm (LL120, n = 8). HIICT consisted of eight sets of pedaling for 20 s with 10 s of passive rest between each set. Initial exercise intensity was set at 135% of VO2peak and decreased by 5% after every two sets. HIICT was performed for 18 sessions during the 6-week period. Pre and post the training period, peak power, peak rpm, average power, and time to reach peak power during WAnT and VO2peak were measured. According to two-way analysis of variance (time × group), the main effect of time was observed in VO2peak, peak power, peak rpm, and average power during WAnT (p < 0.05). However, time × group interaction was not observed for any indices (p > 0.05). Conversely, time × group interaction was observed in time to reach peak power during WAnT, and significantly shortened only in HL60 (p < 0.05). These results suggest the effectiveness of work-matched HIICT with high-load / low cadence on WAnT performance.