著者

Shintaro Togashi Tsuyoshi Isawa Taku Honda Kenichi Furuya Kazuhiro Yamaya Masataka Taguri Shigeru Toyoda

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0103, (Released:2023-05-16)

参考文献数

28

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Background: Because the penetration of transvenous lead extraction (TLE) for cardiac implantable electronic device (CIED) infection has not been investigated in Japan, we conducted a population-based, retrospective, descriptive study to evaluate regional disparities in the use of TLE for CIED infection and the potential undertreatment of CIED infection using a nationwide insurance claims database.Methods and Results: Patients who underwent CIED implantation or generator exchange and TLE between April 2018 and March 2020 were identified. Moreover, the penetration ratio of TLE for CIED infection in each prefecture was estimated. CIED implantation and TLE were most prevalent in the age categories of 80–89 years (40.3%) and 80–89 years (36.9%), respectively. There was no correlation between the number of CIED implantations and that of TLE (rho=−0.087, 95% confidence interval −0.374 to 0.211, P=0.56). The median penetration ratio was 0.00 (interquartile range 0.00–1.29). Of the 47 prefectures, 6, comprising Okinawa, Miyagi, Okayama, Fukuoka, Tokyo, and Osaka, showed a penetration ratio ≥2.00.Conclusions: Our study data indicated great regional disparities in the penetration of TLE and potential undertreatment of CIED infection in Japan. Additional measures are needed to address these issues.

著者

Kosuke Hayashi Kenta Hachiya Keisuke Yonezu Naoyuki Otani Kenichi Furuya Iori Miura Takashi Tomoe Takushi Sugiyama Yasuaki Wada Naohiko Takahashi Naoto Uemura

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0088, (Released:2023-11-29)

参考文献数

12

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Background: The low implementation rate of guideline-directed medical therapy for heart failure (HF) remains a problem worldwide. To address this issue, we hypothesized that a smartphone application (app) based on behavioral economics that nudges physicians and patients towards optimal medical therapy would be a scalable approach.Methods and Results: The app prototype was developed, and its usability was tested with 5 HF patients in the outpatient setting. Adherence to the app was outstanding, with a high usability rating from the patients.Conclusions: It appears feasible to further study our app in a larger cohort to evaluate its efficacy.

著者

Kikunori Shinohara Akitaka Yanagisawa Yutaka Kagota Akira Gomi Kenichi Nemoto Eisuke Moriya Eiichi Furusawa Kenichi Furuya Koji Terasawa

出版者

日本生理人類学会

雑誌

Applied Human Science (ISSN:13413473)

巻号頁・発行日

vol.18, no.2, pp.37-42, 1999-03-30 (Released:2000-04-12)

参考文献数

30

被引用文献数

21 36

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Pachinko is a popular form of recreation in Japan. However, in recent years, along with Pachinko’s popularity, “Pachinko dependence” has become topical news. The purpose of this study was to investigate beta-endorphin, catecholamines, immune system responses and heart rate during the playing of Pachinko. The following significant results were observed. (1) Plasma concentration of beta-endorphin increased before playing Pachinko and while in the Pachinko-center (p<0.05). (2) Beta-endorphin and norepinephrine increased when the player began to win (i.e. at “Fever-start”) compared to baseline (p<0.05). (3) Beta-endorphin, norepinephrine and dopamine increased when the winning streak finished (i.e. at “Fever-end”) compared to baseline (p<0.05-0.01). (4) Norepinephrine increased past 30 minutes after “Fever-end” compared to baseline(p<0.05). (5) Heart rate increased before “Fever-start” compared to baseline, peaked at “Fever-start” and rapidly decreased to match rates measured at rest. But the increase was observed from 200 seconds after “Fever-start” (p<0.05-0.001). (6) There was a positive correlation between the number of hours subjects played Pachinko in a week and the differences between beta-endorphin levels at “Fever-start” and those at rest (p<0.05). (7) The number of T-cells decreased while the number of NK cells increased at “Fever-start” compared to baseline (p<.05). These results suggest that intracerebral substances such as beta-endorphin and dopamine are involved in the habit-forming behavior associated with Pachinko.