- 著者
- Tomoyuki SHIBATA Hiromi YAMASHITA Tomohiko KAWAMURA Yasutaka JODAI Takafumi OMORI Kazuya SUMI Yuichiro ICHIKAWA Masaaki OKUBO Takamitsu ISHIZUKA Tomomitsu TAHARA Mitsuo NAGASAKA Yoshihito NAKAGAWA Ichiro HIRATA Naoki OHMIYA Makoto NAKAO
- 出版者
- バイオメディカルリサーチプレス
- 雑誌
- Biomedical Research (ISSN:03886107)
- 巻号頁・発行日
- vol.37, no.5, pp.305-310, 2016-10-01 (Released:2016-10-25)
- 参考文献数
- 38
- 被引用文献数
- 2
The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status, and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984, Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week, followed by the ingestion of 200 kcal of the test nutrient containing 13C-acetate 15 min later, after which the subjects’ exhalations were collected up to 120 min. The concentration peak of 13C was measured as Tmax. Diamine oxidase (DAO) activity for the marker of small intestinal function activity was also measured the day after the test. Gastric emptying was significantly slower in the group that consumed a small amount of beer, and in daily beer consumption group, and also in the ADH1B *2/*2, ALDH2 *1/*2 genotypes compared to non-beer drinking group. DAO values were not significantly changed between beer and non-beer group. The consumption of even a small amount of beer and the polymorphisms in ADH1B / ALDH2 affects gastric motility.
- 著者
- Makoto Nakao Hideki Muramatsu Tetsushi Takahashi Shunsuke Niwa Yusuke Kagawa Ryota Kurokawa Kazuki Sone Yuki Uozumi Misako Ohkusu Katsuhiko Kamei Hiroshi Koga
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.55, no.20, pp.3021-3024, 2016-10-15 (Released:2016-10-15)
- 参考文献数
- 17
- 被引用文献数
- 10
A 39-year-old man presented to our hospital with a four-week history of headache and a two-week history of low-grade fever. Chest X-rays showed a tumor of approximately 50 mm in size in the right lower field. A histopathological examination of a transbronchial lung biopsy specimen from the right S9/10 revealed numerous fungal elements that appeared as encapsulated yeast with clear halos. Gadolinium-enhanced brain magnetic resonance images showed multiple cerebral nodules. Cryptococcus gattii (Genotype VGIIa) was isolated from the bronchial lavage and cerebrospinal fluid specimens. The patient was an immunocompetent Japanese man who had not recently traveled to a C. gattii-endemic area.