著者

Masaki Yoshioka Keisei Kosaki Masahiro Matsui Shoya Mori Natsumi Nishitani Chie Saito Kunihiro Yamagata Makoto Kuro-o Seiji Maeda

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ22-0063, (Released:2022-09-03)

被引用文献数

3

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Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone secreted by the bone in response to dietary phosphate intake. Since the phosphate content in the diet correlates with the protein content, both plant- and animal-based protein intake can increase the serum FGF23 level. However, a higher percentage of energy from plant protein than from animal protein is associated with a lower serum FGF23 level in patients with chronic kidney disease (CKD) in the United States. Since dietary habits differ between Asian and Western populations, we performed a cross-sectional study to determine the association between the percentages of energy from plant and animal proteins and the serum FGF23 level in Japanese CKD patients. In 107 non-dialysis CKD patients (age: 66 ± 9 years; estimated glomerular filtration rate: 56 ± 21 mL/min/1.73 m2), the percentages of energy from plant and animal proteins were assessed using a food frequency questionnaire based on food groups. Venous blood samples were used to measure the serum FGF23, phosphate, 1,25-dihydroxyvitamin D, and intact parathyroid hormone levels. The percentages of energy from plant and animal proteins showed a negative and positive association, respectively, with the serum FGF23 level. Furthermore, isocaloric substitution modeling showed that replacing animal protein with plant protein was associated with a low serum FGF23 level. Our findings suggest that encouraging diets with high plant protein level may prevent an increase in the serum FGF23 level in Japanese CKD patients.

著者

吉岡 真佐樹 Masaki YOSHIOKA

雑誌

京都府立大学学術報告. 人文・社会 = The scientific reports of Kyoto Prefectural University. Humanities and social science (ISSN:13433946)

巻号頁・発行日

vol.50, pp.97-119, 1998-12-25

著者

Masaki Yoshioka Shintaro Yokoyama Satoshi Koguchi Koichi Ikeda

出版者

Japanese Society of Human-Environment System

雑誌

人間-生活環境系学会英文誌 (ISSN:13451324)

巻号頁・発行日

vol.12, no.2, pp.73-77, 2009-12-30 (Released:2010-07-08)

参考文献数

8

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We intended to clarify the present states of special old age nursing homes and elderly health care facilities in Japan especially in a cold climate region. A questionnaire survey about maintenance and control of living environment for all special old age nursing homes and elderly health care facilities in Sapporo and Fukuoka City, and Hokkaido, Saitama, Kanagawa, Osaka Prefecture and Tokyo Metropolis was performed. The main questionnaire asks about heating, air-cooling, ventilation system, sanitary system and indoor air quality including bio-aerosol and odors. We send the questionnaire sheets, which were A-4 size and four pages, to total 1,479 homes and facilities. We received total 646 answers, about 44% of total number. The 95 questionnaire items were converted 249 categories for statistical analyses.The present database for special old age nursing homes and elderly health care facilities consists of about 160,000 data. The data obtained from Sapporo City and Hokkaido Prefecture were compared with those of other regions. We show the characteristics of special old age nursing homes and elderly health care facilities in a cold climate region in this paper. The main differences were set values of air temperature in both winter and mid-summer, and air-cooling system.