著者

Masaki Yoshioka Keisei Kosaki Masahiro Matsui Shoya Mori Natsumi Nishitani Chie Saito Kunihiro Yamagata Makoto Kuro-o Seiji Maeda

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ22-0063, (Released:2022-09-03)

被引用文献数

3

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Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone secreted by the bone in response to dietary phosphate intake. Since the phosphate content in the diet correlates with the protein content, both plant- and animal-based protein intake can increase the serum FGF23 level. However, a higher percentage of energy from plant protein than from animal protein is associated with a lower serum FGF23 level in patients with chronic kidney disease (CKD) in the United States. Since dietary habits differ between Asian and Western populations, we performed a cross-sectional study to determine the association between the percentages of energy from plant and animal proteins and the serum FGF23 level in Japanese CKD patients. In 107 non-dialysis CKD patients (age: 66 ± 9 years; estimated glomerular filtration rate: 56 ± 21 mL/min/1.73 m2), the percentages of energy from plant and animal proteins were assessed using a food frequency questionnaire based on food groups. Venous blood samples were used to measure the serum FGF23, phosphate, 1,25-dihydroxyvitamin D, and intact parathyroid hormone levels. The percentages of energy from plant and animal proteins showed a negative and positive association, respectively, with the serum FGF23 level. Furthermore, isocaloric substitution modeling showed that replacing animal protein with plant protein was associated with a low serum FGF23 level. Our findings suggest that encouraging diets with high plant protein level may prevent an increase in the serum FGF23 level in Japanese CKD patients.

著者

Tomohito Sato Keisei Kosaki Youngju Choi Yuriko Tochigi Ai Shindo-Hamasaki Reiko Momma Seiji Maeda

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.11, no.4, pp.247-253, 2022-07-25 (Released:2022-07-12)

参考文献数

26

被引用文献数

3

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Several studies have demonstrated that athletes show superior performance in general cognitive functions compared to non-athletes. However, the effects on cognitive function might vary depending on the athlete’s sport type. In athletes, the visuospatial working memory is a crucial function for immediate response to each situation and experience. However, no studies have yet examined the association between visuospatial working memory and sport types. This study aimed to investigate whether sport type influences the differences in visuospatial working memory in athletes using a cross-sectional study. A total of 67 young individuals, including 59 athletes (long-distance running, tennis, kendo, and soccer players) and eight non-athletes (controls), participated in the study. Athletes were classified into static, interceptive, or strategic depending on their sport type. The reaction time, accuracy, and balanced integration score (BIS) of the spatial working memory task (SWMT) were examined in all participants. Strategic athletes showed a shorter reaction time and higher BIS value of SWMT than static athletes and non-athletes. We concluded that the visuospatial working memory of strategic athletes was better than that of non-athletes and static athletes. This finding suggests that visuospatial working memory might play an important role in determining athletic performance in strategic sport types, making improved visuospatial working memory a key advantage for strategic athletes.

著者

Keisei Kosaki Atsumu Yokota Koichiro Tanahashi Kanae Myoenzono Jiyeon Park Toru Yoshikawa Yasuko Yoshida Takayo Murase Seigo Akari Takashi Nakamura Seiji Maeda

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

pp.21-118, (Released:2022-04-12)

参考文献数

30

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Circulating xanthine oxidoreductase (XOR) activity may contribute to the pathogenesis of obesity-related adverse cardiometabolic profiles. This pilot study aimed to examine the cross-sectional associations between plasma XOR activity and cardiometabolic risk (CMR) markers in overweight and obese men. In 64 overweight and obese Japanese men (aged 31–63 years), plasma XOR activity and several CMR markers, such as homeostasis model assessment of insulin resistance (HOMA-IR), and clustered CMR score were measured in each participant. Clustered CMR score was constructed based on waist circumference, triglyceride, blood pressure, fasting plasma glucose, and high-density lipoprotein cholesterol. Plasma XOR activity in overweight and obese men was positively associated with the body mass index, waist circumference, visceral fat area, body fat mass, hemoglobin A1c, serum 8-hydroxy-2'-deoxyguanosine, HOMA-IR, and clustered CMR score and was inversely associated with handgrip strength and high-density lipoprotein cholesterol. Multiple linear regression analysis further demonstrated that the associations of plasma XOR activity with HOMA-IR and the clustered CMR score remained significant after adjustment for covariates including uric acid. Our data demonstrate that circulating XOR activity was independently associated, albeit modestly, with HOMA-IR and the clustered CMR score. These preliminary findings suggest that circulating XOR activity can potentially be one of the preventive targets and biomarkers of cardiometabolic disorders in over­weight and obese men.