著者

Kazuhiro Yamamoto Miyuki Tsuchihashi-Makaya Yoshiharu Kinugasa Yuki Iida Kentaro Kamiya Yasuki Kihara Yuji Kono Yukihito Sato Norio Suzuki Harumi Takeuchi Taiki Higo Yasushi Miyazawa Isao Miyajima Akira Yamashina Katsushi Yoshita Koichi Washida Masafumi Kuzuya Tetsuya Takahashi Yutaka Nakaya Naoyuki Hasebe Hiroyuki Tsutsui on behalf of The Japanese Heart Failure Society Expert Consensus Writing Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0322, (Released:2020-07-10)

参考文献数

206

被引用文献数

21

著者

Jun-ichi Kawabe Fumitaka Ushikubi Naoyuki Hasebe

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.74, no.5, pp.836-843, 2010 (Released:2010-04-23)

参考文献数

86

被引用文献数

81 86

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Prostacyclin (PGI2) is one of the important vascular prostanoids, the effects of which counteract those of thromboxane (TXA2), and these 2 prostanoids provide an important balance in cardiovascular homeostasis. The clinical experience of COX-2 selective inhibitors having unexpected adverse effects in patients with cardiovascular risk has opened up a debate about the role of COX-2-derived prostanoids in vascular pathophysiology. PGI2 is a major anti-atherogenic prostanoid produced by COX-2 in vascular cells, including endothelial and vascular smooth muscle cells. The balance between COX-2-derived PGI2, COX-1-derived TXA2, and other COX-2-mediated atherogenic prostanoids is a crucial factor in determining pathophysiological outcomes. Recent studies using stable PGI2 analogs and genetically deficient mice have revealed novel effects of PGI2 on its target cells, such as endothelial and endothelial progenitor cells. The role PGI2 in the physiology and pathophysiology of vascular diseases is reviewed and the recent findings linking PGI2, COX-2 and atherothrombosis are summarized. (Circ J 2010; 74: 836 - 843)

著者

Asami Nimura Nobuyuki Sato Hitoshi Sakuragi Satoshi Koyama Junichi Maruyama Ahmed Karim Talib Naoki Nakagawa Naka Sakamoto Hisanobu Ota Yasuko Tanabe Toshiharu Takeuchi Yuichiro Kawamura Naoyuki Hasebe

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.50, no.18, pp.1957-1961, 2011 (Released:2011-09-15)

参考文献数

14

被引用文献数

5

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We describe a case of advanced atrioventricular (AV) block, in which treatment with cilostazol was effective in recovering the AV conduction. The patient was referred to our hospital for close examination of the advanced AV block and permanent pacemaker implantation. Although the patient had experienced third-degree AV block with occasional AV synchrony for more than two days, the AV conduction completely recovered after treatment with oral cilostazol at 200 mg/day. Here we discuss the possible mechanism of the improvement in the AV conduction by cilostazol.