- 著者
 
          - 
             
             Yoshiharu Kinugasa
             
             Masahiko Kato
             
             Shinobu Sugihara
             
             Masayuki Hirai
             
             Kensaku Yamada
             
             Kiyotaka Yanagihara
             
             Kazuhiro Yamamoto
             
          
 
          
          
          - 出版者
 
          - The Japanese Circulation Society
 
          
          
          - 雑誌
 
          - Circulation Journal (ISSN:13469843)
 
          
          
          - 巻号頁・発行日
 
          - vol.77, no.3, pp.705-711, 2013 (Released:2013-02-25)
 
          
          
          - 参考文献数
 
          - 32
 
          
          
          - 被引用文献数
 
          - 
             
             92
             
             
             208
             
             
             15
 
             
          
        
        
        
        Background: The clinical significance of nutritional risk assessment in patients with heart failure with preserved ejection fraction (HFpEF) remains undefined. Geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool for elderly subjects. Its predictive value was evaluated in patients with HFpEF, a common HF phenotype in the elderly population. Methods and Results: The present study enrolled 152 consecutive patients (mean age, 77±11 years; male, 53.9%) who were hospitalized with HFpEF at the authors’ institution. GNRI on admission was calculated as follows: 14.89×serum albumin (g/dl)+41.7×body mass index/22. Characteristics and mortality (median follow-up of 2.1 years) were compared between 2 groups: low GNRI (<92) with moderate or severe nutritional risk; and high GNRI (≥92) with no or low nutritional risk. Patients in the low-GNRI group were more often female, and had lower serum hemoglobin and sodium, but higher serum blood urea nitrogen (BUN), C-reactive protein, and B-type natriuretic peptide (BNP) compared to those in the high-GNRI group (P<0.05, respectively). Physical activity at discharge measured by Barthel index was significantly lower in the low-GNRI group than the high-GNRI group (P<0.05). On Cox hazard analysis, lower GNRI predicted increased mortality independent of age, gender, prior HF hospitalization, and higher BUN and BNP (P<0.01). Conclusions: GNRI may be useful for predicting functional dependency and mortality in patients with HFpEF.  (Circ J 2013; 77: 705–711)