1 0 0 0 OA Cigarette Smoking and the Risk of the Metabolic Syndrome in Middle-Aged Japanese Male Office Workers
- 著者
- Noriyuki NAKANISHI Toshio TAKATORIGE Kenji SUZUKI
- 出版者
- National Institute of Occupational Safety and Health
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- vol.43, no.2, pp.295-301, 2005 (Released:2006-03-17)
- 参考文献数
- 35
- 被引用文献数
- 66 69
To examine the association between cigarette smoking and the risk of the metabolic syndrome (MS), 3,649 Japanese male office workers aged 35-59 yr who did not have a history of cardiovascular disease were enrolled in this study. 2,994 men without the MS at entry were followed up over a 7-yr period. A modified National Cholesterol Education Program definition with body mass index instead of waist circumference was used for the MS. With adjustment for age, family history of diabetes, alcohol intake, and regular physical activity, the odds ratios of the MS were 1.0 (referent), 1.30 (95% confidence interval (CI), 1.00-1.68), 1.07 (95% CI, 0.82-1.39), 1.17 (95% CI, 0.88-1.56), and 1.66 (95% CI, 1.24-2.20) for never smokers, ex-smokers, and those who smoked 1-20 cigarettes/d, 21-30 cigarettes/d, and ≥31 cigarettes/d, respectively (P for trend for current smokers only =0.006). As for the risk of developing the MS, the respective multivariate-adjusted hazard ratios of developing the MS were 1.0 (referent), 1.43 (95% CI, 1.14-1.79), 1.14 (95% CI, 0.91-1.44), 1.45 (95% CI, 1.14-1.84), and 1.59 (95% CI, 1.24-2.05) (P for trend for current smokers only =0.001). Among men without the MS at entry, body weight gain over 7 yr, compared with never smokers, was significantly higher in smokers who quit smoking. It is important for the prevention of the MS not only to quit smoking but also to prevent weight gain after smoking cessation.
1 0 0 0 OA TMC-205 a New Transcriptional Up-Regulator of SV40 Promoter Produced by an Unidentified Fungus
- 著者
- MASAAKI SAKURAI JUN KOHNO MAKI NISHIO KOZO YAMAMOTO TORU OKUDA KIMIO KAWANO NORIYUKI NAKANISHI
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.54, no.8, pp.628-634, 2001-08-25 (Released:2008-09-19)
- 参考文献数
- 12
- 被引用文献数
- 10 9
A new transcriptional up-regulator designated TMC-205 was discovered from the fermentation broth of an unidentified fungal strain TC 1630 by using an SV40 promoterluciferase reporter assay. Based on spectroscopic analyses, its structure was determined to be (E)-6-(3-methyl-1, 3-butadienyl)-1H-indole-3-carboxylic acid. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100μM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.