- 著者
- 反町 篤行 床次 眞司 Miroslaw JANIK 石川 徹夫 Sarata K. SAHOO 吉永 信治 米原 英典 酒井 一夫 山澤 弘実 秋葉 澄伯 古川 雅英 Quanfu SUN Yong-Jae KIM Supitcha CHANYOTHA Rakesh C. RAMOLA
- 出版者
- 日本保健物理学会
- 雑誌
- 保健物理 (ISSN:03676110)
- 巻号頁・発行日
- vol.45, no.1, pp.15-18, 2010 (Released:2011-02-04)
- 参考文献数
- 4
- 被引用文献数
- 1 1 1
- 著者
- JIANMING ZOU QUANFU SUN SUMINORI AKIBA YONGLING YUAN YONGRU ZHA ZUFAN TAO LUXIN WEI TSUTOMU SUGAHARA
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.41, no.SUPPL, pp.S53-S62, 2000 (Released:2001-10-19)
- 参考文献数
- 17
- 被引用文献数
- 41
The main purposes of this study were to identify the major determinants of nasopharyngeal carcinoma (NPC) in the high-background radiation areas (HBRA) in Yangjiang, China and to evaluate their potential confounding effects on the NPC risk associated with exposure to high background radiation. A matched case-control study was conducted using those who died of NPC during the period 1987-1995. Two controls were randomly selected for each case from those who died from causes other than malignancies and external causes. Cases and their controls were matched with respect to sex and the years of birth and death (±5 years). Study subjects' next-of-kin were interviewed using a standardized questionnaire to collect information on socioeconomic status, dietary habits, tobacco smoking and alcohol consumption, disease history, pesticide use, medical X-ray exposure, the family history of NPC and so on. We succeeded in interviewing 97 cases and 192 controls. Univariate conditional logistic regression analysis showed that NPC risk was associated with the consumption of salted fish, homemade pickles, and fermented soy beans, education levels, the history of chronic rhinitis, and the family history of NPC. Multivariate conditional logistic regression analysis revealed that education levels (Odds ratio (OR) for middle school or higher levels vs. no school education=3.8, 95% CI=1.2 to 11.8), salted fish intake (OR=3.2, 95% CI=1.7 to 6.1), the history of chronic rhinitis (OR=3.6, 95% CI=1.3 to 10.1), and the family history of NPC (OR=14.2, 95% CI=2.7 to 73.4) were independent risk factors of NPC. Tobacco smoking (OR=1.2, 95% CI=0.7 to 2.1), and alcohol consumption (OR=0.9, 95% CI=0.5 to 1.9) were not significantly related to NPC risk. The ORs of NPC risk comparing HBRA and a nearby control area before and after adjustment for the major risk determinants identified in the present study were 0.86 (95% CI=0.50 to 1.50) and 0.87 (95% CI=0.45 to 1.67), respectively. Salted fish intake was a strong risk factor of NPC. Education, the history of chronic rhinitis and the family history of NPC were also related to NPC risk. The exposure to high background radiation in HBRA of Yangjiang was not related to NPC risk with or without the adjustment for those major risk determinants of NPC.
- 著者
- QUANFU SUN SUMINORI AKIBA ZUFAN TAO YONGLING YUAN JIANMING ZOU HIROSHIGE MORISHIMA HIROO KATO YONGRU ZHA TSUTOMU SUGAHARA LUXIN WEI
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.41, no.SUPPL, pp.S43-S52, 2000 (Released:2001-10-19)
- 参考文献数
- 18
- 被引用文献数
- 19
A study was made on cancer mortality in the high-background radiation areas of Yangjiang, China. Based on hamlet-specific environmental doses and sex- and age-specific occupancy factors, cumulative doses were calculated for each subject. In this article, we describe how the indirect estimation was made on individual dose and the methodology used to estimate radiation risk. Then, assuming a linear dose response relationship and using cancer mortality data for the period 1979-1995, we estimate the excess relative risk per Sievert for solid cancer to be -0.11 (95% CI, -0.67, 0.69). Also, we estimate the excess relative risks of four leading cancers in the study areas, i.e., cancers of the liver, nasopharynx, lung and stomach. In addition, we evaluate the effects of possible bias on our risk estimation.