- 著者
- Ryosuke Sato Yasushi Matsuzawa Tomohiro Yoshii Eiichi Akiyama Masaaki Konishi Hidefumi Nakahashi Yugo Minamimoto Yuichiro Kimura Kozo Okada Nobuhiko Maejima Noriaki Iwahashi Masami Kosuge Toshiaki Ebina Kazuo Kimura Kouichi Tamura Kiyoshi Hibi
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- pp.64368, (Released:2023-10-12)
- 参考文献数
- 48
Aim: Low-density lipoprotein cholesterol (LDL-C) level reduction is highly effective in preventing the occurrence of a cardiovascular event. Contrariwise, an inverse association exists between LDL-C levels and prognosis in some patients with cardiovascular diseases—the so-called “cholesterol paradox.” This study aimed to investigate whether the LDL-C level on admission affects the long-term prognosis in patients who develop acute coronary syndrome (ACS) and to examine factors associated with poor prognosis in patients with low LDL-C levels. Methods: We enrolled 410 statin-naïve patients with ACS, whom we divided into low- and high-LDL-C groups based on an admission LDL-C cut-off (obtained from the Youden index) of 122 mg/dL. Endothelial function was assessed using the reactive hyperemia index 1 week after statin initiation. The primary composite endpoint included all-cause death, as well as myocardial infarction and ischemic stroke occurrences. Results: During a median follow-up period of 6.1 years, 76 patients experienced the primary endpoint. Multivariate Cox regression analysis revealed that patients in the low LDL-C group had a 2.3-fold higher risk of experiencing the primary endpoint than those in the high LDL-C group (hazard ratio, 2.34; 95% confidence interval, 1.29-4.27; p=0.005). In the low LDL-C group, slow gait speed (frailty), elevated chronic-phase high-sensitivity C-reactive protein levels (chronic inflammation), and endothelial dysfunction were significantly associated with the primary endpoint. Conclusions: Patients with low LDL-C levels at admission due to ACS had a significantly worse long-term prognosis than those with high LDL-C levels; frailty, chronic inflammation, and endothelial dysfunction were poor prognostic factors.
- 著者
- Mitsuhiro MATSU'URA Takaya IWASAKI Yasunori SUZUKI Ryosuke SATO
- 出版者
- The Seismological Society of Japan, The Volcanological Society of Japan , The Geodetic Society of Japan
- 雑誌
- Journal of Physics of the Earth (ISSN:00223743)
- 巻号頁・発行日
- vol.28, no.2, pp.119-143, 1980 (Released:2009-04-30)
- 参考文献数
- 28
- 被引用文献数
- 30 53
An inverse method to find optimum fault parameters from geodetic data with random errors is extended so as to be applicable to a case of the data including a systematic error caused by movements of reference points in triangulation. Application of the new inverse method to static displacement data associated with the Kanto earthquake of 1923 yields a dislocation source model which adequately explains both the seismological and the geodetic data.From the geodetic data, it is found that the fault motion of the Kanto earthquake is a reverse, right-lateral slip of 4.8m with a slip-angle of 140° on a plane which dips 25° towards N24°E, where the slip-angle is measured counterclockwise from a strike on the fault plane. The fault length, width, and the depth to the upper fault margin are determined as 95km, 54km, and 1.5km respectively. The seismic moment and stress drop of this earthquake are estimated to be 8.4×1027 dyne·cm and 45 bars, respectively.Taking the static fault solution as the basic model, the dynamic process of the fracture is investigated on the basis of the long-period seismograms recorded at Hongo, Tokyo. The result shows that the rupture starts from a relocated hypocenter, 35.41°N, 139.22°E and 13.5km (depth), and extends outwards on the fault plane with a propagating velocity of the rupture front of 2.0km/sec. The rise time of the source time function is assumed to be 5.0sec. The maximum amplitude of acceleration for a frequency range of 0.0-3.3Hz at Tokyo is estimated to be about 280gal for the horizontal component and to be 60gal for the vertical component, by applying an empirical formula to the calculated ground displacements.