著者

Keisuke Nagasaki Akie Nakamura Takeru Yamauchi Hotaka Kamasaki Yosuke Hara Junko Kanno Satomi Koyama Yoshiaki Ohtsu Ikuko Takahashi Shigeru Suzuki Kenichi Kashimada Toshihiro Tajima

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.30, no.2, pp.79-84, 2021 (Released:2021-04-03)

参考文献数

16

被引用文献数

2

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Atrophic autoimmune thyroiditis (AAT) is a type of autoimmune hypothyroidism without goiter. TSH receptor-blocking antibodies (TSBAb) are involved in its etiology in adults. Reportedly, this disease is extremely rare in children. In this study, we aimed to investigate the prevalence of TSBAb during AAT onset in children using a commercially available cell-based bioassay TSAb kit. We conducted a multicenter retrospective observational study. We collected data of patients with AAT who were < 15 yr old, enrolled in a collaborative research group, and diagnosed since July 2003. AAT was defined as acquired autoimmune hypothyroidism without thyroid enlargement. Eighteen patients (including 15 females) whose TSH receptor antibody (TRAb) or TSBAb levels were measured within a year from the initial visit were included. The median age at diagnosis was 9.3 years, and the estimated time between onset and diagnosis was 2.6 yr. The positive rate for either TSBAb or TRAb was 38.8% (95% confidence interval: 18.3–59.5%). There were no significant differences in age, the estimated time between onset and diagnosis, and FT4 levels at diagnosis between the TSBAb-positive and -negative groups. Unlike previous reports, we showed that the prevalence of TSBAb-positivity in childhood-onset AATs is not rare, as in adults.

著者

Osamu Arisaka Megumi Iijima-Nozawa Yukiko Shimada Yoshiya Ito George Imataka Junko Naganuma Go Ichikawa Satomi Koyama

出版者

獨協医学会

雑誌

Dokkyo Journal of Medical Sciences (ISSN:03855023)

巻号頁・発行日

vol.48, no.1, pp.1-7, 2021-03-25

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Human behavioral sex differences are currently understood to result from a combination of social, cultural, cognitive, and biological mechanisms. To understand how gender identity as the sexuality of the mind is formed is important for understanding psychosexual problems of children and to consider how to manage patients with disorders of sex development(DSD), in which the development of gonads and genitals is atypical and it is difficult to determine the gender of boys and girls. There is consistent evidence that early testosterone exposure influences childhood gender role behavior, as well as gender identity and sexual orientation. In this review, we summarize the most relevant studies on the biological basis of sexual development. In particular, we focus on the impact of sex hormones and genetic background on development of sexual differentiation and gender identity, with introduction of our research using figure drawings by pediatric patients with congenital adrenal hyperplasia, which is also a DSD.