著者

Mariko Harada-Shiba John J.P. Kastelein G. Kees Hovingh Kausik K. Ray Akira Ohtake Osamu Arisaka Takao Ohta Tomoo Okada Hideki Suganami Albert Wiegman

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.42242, (Released:2017-11-29)

参考文献数

24

被引用文献数

17

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Aim: Children with Familial Hypercholesterolemia (FH) are widely prescribed statins, and it has been suggested that the effects of statins differ among ethnicities. We compared the efficacy and safety of pitavastatin in children and adolescents with FH in clinical trials conducted in Japan and Europe.

著者

加藤 正也 今高 城治 岡本 健太郎 谷 有希子 山口 岳史 荻野 恵 土岡 丘 加藤 広行 有阪 治 Masaya Kato George Imataka Kentaro Okamoto Yukiko Tani Takeshi Yamaguchi Kei Ogino Takashi Tuchioka Hiroyuki Kato Osamu Arisaka 獨協医科大学医学部 小児科学 獨協医科大学医学部 小児科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 第一外科学 獨協医科大学医学部 小児科学 Department Of Pediatrics Dokkyo Medical University Department Of Pediatrics Dokkyo Medical University First Department Of Surgery Dokkyo Medical University First Department Of Surgery Dokkyo Medical University First Department Of Surgery Dokkyo Medical University First Department Of Surgery Dokkyo Medical University First Department Of Surgery Dokkyo Medical University First Department Of Surgery Dokkyo Medical University Department Of Pediatrics Dokkyo Medical University

雑誌

Dokkyo journal of medical sciences (ISSN:03855023)

巻号頁・発行日

vol.41, no.2, pp.173-176, 2014-07-25

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症例1は6歳女児.インフルエンザ感染症初日に発熱しオセルタミビルを開始.第3病日,右下腹部に限局した圧痛が出現.腹部造影CTで糞石を認め急性虫垂炎と診断.保存的に加療し炎症反応と腹痛は改善した.症例2は5歳女児.第1病日に発熱と腹痛を認め,第3病日に鼻咽腔迅速検査でインフルエンザB型と診断しザナミビル吸入を開始.触診で右下腹部に反跳痛を認め,腹部単純CTで虫垂壁の肥厚と糞石を確認.急性虫垂炎の併発と診断し,第4病日に虫垂切除術を施行.切除虫垂に膿瘍を認め腹腔ドレーンを留置.第5病日に解熱し経過は順調であった.インフルエンザに伴う腹痛では感染に付随する腹痛と断定せず急性虫垂炎の可能性も考慮し腹部CTなどの画像検査を行うことが肝要である.

著者

渡部 弥栄子 今高 城治 斎藤 祥子 岩波 久威 鈴木 紫布 金谷 英明 桑島 成子 有阪 治 Yaeko Watabe George Imataka Shoko Saito Hisatake Iwanami Shiho Suzuki Hideaki Kanaya Shigeko Kuwashima Osamu Arisaka 獨協医科大学医学部 小児科学 獨協医科大学医学部 小児科学 獨協医科大学医学部 小児科学 獨協医科大学医学部 内科学(神経) 獨協医科大学医学部 内科学(神経) 獨協医科大学医学部 脳神経外科 獨協医科大学医学部 放射線科 獨協医科大学医学部 小児科学 Departments Of Pediatrics Dokkyo Medical University School Of Medicine Departments Of Pediatrics Dokkyo Medical University School Of Medicine Departments Of Pediatrics Dokkyo Medical University School Of Medicine Neurology Dokkyo Medical University School Of Medicine Neurology Dokkyo Medical University School Of Medicine Neurosurgery Dokkyo Medical University School Of Medicine Radiology Dokkyo Medical University School Of Medicine Departments Of Pediatrics Dokkyo Medical University School Of Medicine

雑誌

Dokkyo journal of medical sciences (ISSN:03855023)

巻号頁・発行日

vol.41, no.2, pp.177-181, 2014-07-25

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Tolosa-Hunt症候群(THS)は先行する片側眼窩部痛と眼球運動障害を生じ,病態は海綿静脈洞の非特異的炎症性肉芽腫病変と推測されている.発症は年間100万人あたり1人前後で,40歳台の成人に多く小児例は稀である.今回,1カ月続く右眼をえぐられる様な頭痛を主訴とした15歳のTHSを報告する.発症後,各種頭痛薬で改善がなく,各種検査を施行し異常がないため心身症に伴う反復する片頭痛と診断された.当院で脳MRIを施行し右内頸動脈の狭窄を認めTHSと確定診断した.プレドニゾロン(PSL)1?mg/kg/dayを朝1回開始し,翌日頭痛は改善した.以降,半年かけてPSLを漸減し再発はない.Tolosa-Hunt syndrome(THS)is characterized by periorbital pain accompanying opthalmoplegia. The pathogenesis is considered to involve non-specific granulomatous inflammation in the cavernous sinus, and the frequency is around one case per year per million people. Symptoms usually develop in adulthood, and pediatric cases are rare. We report herein a case of THS in a 15-year-old girl whose headache was diagnosed as psychosomatic disease in the early stage of the clinical course. Her chief compliant was headache with strong pain in the right eye, continuing for 1 month. Although several medications were trialed to alleviate headaches, no improvement was achieved. Various physical examinations proved uninformative. Headache was therefore tentatively diagnosed as psychosomatic disease associated with migraine. Brain magnetic resonance imaging in our university hospital revealed strangulation of the internal carotid artery, and headache was diagnosed as confirmed THS. Oral administration of prednisolone was started at 1 mg/kg/day, given once in the morning. Headache improved from the next day. Oral therapy with prednisolone was tapered over the course of 6 months and headache did not recur.

著者

今高 城治 塚田 佳子 藤澤 正英 宮本 健志 萩澤 進 山内 秀雄 平尾 準一 有阪 治 George Imataka Keiko Tsukada Masahide Fujisawa Kenji Miyamoto Susumu Hagiwara Hideo Yamanouchi Jun-ichi Hirano Osamu Arisaka 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 獨協医科大学小児科学 Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine Department of Pediatrics Dokkyo Medical University School of Medicine

雑誌

Dokkyo journal of medical sciences (ISSN:03855023)

巻号頁・発行日

vol.36, no.3, pp.161-165, 2009-10-25

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当院で臨床的に脳死状態と判定してから長期間の入院経過をたどった3小児例を報告した.脳死判定の基準は,平成11年度・厚生省「小児における脳死判定基準」を参考とした.国内の小児脳死症例調査の蓄積は十分ではないが,小児の脳死では長期間の経過をたどる例が多く問題視されている.現在,当院の小児病棟には,長期の臨床的脳死児を管理するための終末期医療に適した病床環境がなく,一般の急性期入院児と同室で長期脳死児の管理を行っている.当院の小児病棟に終末期ケアの可能なベッドが一日でも早く確保されることが望まれる.We herein report three pediatric cases that stayed at ourhospital for a long period of time after they were determinedto be clinically brain death. The "Criteria for the diagnosisof brain death in children" issued by the Ministry ofWelfare in 1999 was referred to for determining braindeath. Although a sufficient number of pediatric cases ofbrain death in Japan has not yet been accumulated, one ofthe problems has been that many pediatric cases of braindeath involve a long-term course. The pediatric ward ofour hospital currently does not have an environment suitablefor end-of-life care to manage pediatric cases sufferingfrom long-term clinical brain death, so child patients withlong-term brain death are currently being managed togetherwith general pediatric cases of acute-phase hospitalization.It is hoped that terminal-phase beds that enable longtermtreatment and management will be secured in thepediatric ward of our hospital as soon as possible.

著者

Mariko Harada-Shiba Osamu Arisaka Akira Ohtake Tomoo Okada Hideki Suganami NK-104-PH 01 study registration group

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.23, no.1, pp.48-55, 2016-01-06 (Released:2016-01-06)

参考文献数

14

被引用文献数

2 15 2

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Aim: The purpose of this study was to evaluate the efficacy and safety of LIVALO® tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH).Methods: A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin (1 mg/day or 2 mg/day) was administered orally for 52 weeks.The primary endpoint was the percent change in the LDL-cholesterol (LDL-C) concentrations from baseline to endpoint (repeated measures ANCOVA at Weeks 8 and 12). Secondary endpoints included the percentage of patients who achieved the target LDL-C concentration and percent changes in the levels of lipoprotein and lipid parameters at the visit performed at 52 weeks.Results: The percent change in LDL-C from baseline (mean 258 mg/dL for all patients) to the endpoint was -27.3% (95%CI; -34.0, -20.5) and -34.3% (95%CI; -41.0, -27.5) in the patients receiving 1 mg and 2 mg of pitavastatin, respectively. Stable reductions in the total cholesterol (TC), non-HDL cholesterol (non-HDL-C), apolipoprotein B (Apo-B) and LDL-C levels and non-HDL-C/HDL-C and Apo-B/Apo-A1 ratios were observed up to 52 weeks in both groups. One patient in each dose group (14%) reached the treatment target level of 130 mg/dL.Adverse events were observed in seven (100%) patients receiving 1 mg and five (71%) patients receiving 2 mg of pitavastatin, although none were considered related to the study treatment. One patient in the 1 mg group reported a musculoskeletal AE; however, it was attributed to recent excessive exercise.Conclusions: Pitavastatin significantly reduced the LDL-C levels and was well tolerated when administered at usual adult doses in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin is a promising therapeutic agent for pediatric dyslipidemia with few safety concerns.

著者

Osamu Arisaka Megumi Iijima-Nozawa Yukiko Shimada Yoshiya Ito George Imataka Junko Naganuma Go Ichikawa Satomi Koyama

出版者

獨協医学会

雑誌

Dokkyo Journal of Medical Sciences (ISSN:03855023)

巻号頁・発行日

vol.48, no.1, pp.1-7, 2021-03-25

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Human behavioral sex differences are currently understood to result from a combination of social, cultural, cognitive, and biological mechanisms. To understand how gender identity as the sexuality of the mind is formed is important for understanding psychosexual problems of children and to consider how to manage patients with disorders of sex development(DSD), in which the development of gonads and genitals is atypical and it is difficult to determine the gender of boys and girls. There is consistent evidence that early testosterone exposure influences childhood gender role behavior, as well as gender identity and sexual orientation. In this review, we summarize the most relevant studies on the biological basis of sexual development. In particular, we focus on the impact of sex hormones and genetic background on development of sexual differentiation and gender identity, with introduction of our research using figure drawings by pediatric patients with congenital adrenal hyperplasia, which is also a DSD.