著者

Yasuhiro HOSAKI Nobuyoshi SHIOZAWA Kozo ASHIDA Satoshi WATANABE Taichi ISHIZAWA Mitsuo TSUNAKAWA Shingo YANO Fumihiro MITSUNOBU

出版者

The Japanese Society of Balneology, Climatology and Physical Medicine

雑誌

日本温泉気候物理医学会雑誌 (ISSN:00290343)

巻号頁・発行日

vol.77, no.5, pp.554-555, 2014-08-29 (Released:2015-01-15)

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Purpose: We have previously reported the physiological and biochemical effects of bath salts. In this study, we used bath additive containing artificial carbon dioxide and sodium chloride (S bath additive), and the acute effects of bathing once with S bath additive and chronic effects of daily bathing with S bath additive for 15 consecutive days were compared with the effects of bathing once in plain water. Improvement in 10 symptoms was investigated using a 5-point verbal rating scale (VRS).Methods: Nine patients aged 51-82 years (mean, 66.6 years) with cold intolerance and lower leg pain were treated with balneotherapy. Whole-body bathing at 40°C was performed for 10 min daily (day 1, bathing in plain water; days 2-16, bathing with S bath additive). On days 1, 2, and 16, changes in patient’s subjective symptoms were evaluated using a VRS ranging from -1 to +3.Results: Compared with bathing once in plain water, bathing once with S bath additive was improvement of coldness, body warmth, blood circulation promotion, limb warmth, lightness of foot, and coldness in limbs. Daily bathing with S bath additive for 15 days significantly improved all symptoms compared with bathing in plain water. A comparison between single and daily bathing with S bath additive showed that relieving fatigue and lumbago were significantly improved after consecutive bathing, demonstrating the benefits of long-term usage.Discussion: Bathing once with S bath additive had acute effects on symptoms associated with peripheral circulation, such as coldness in limbs, body warmth, and limb warmth. Daily bathing with S bath additive improved bone- and joint-related symptoms, such as lumbago and shoulder stiffness, demonstrating that the chronic effects of S bath additive differ from the acute ones. These results are consistent with previous studies on natural hot springs which found that the efficacy of short-term treatment was distinct from that obtained after >2 weeks of treatment.

著者

Katsunori Yamaura Kohei Ogawa Taeko Yonekawa Tomonori Nakamura Shingo Yano Koichi Ueno

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.25, no.2, pp.201-205, 2002 (Released:2002-04-27)

参考文献数

44

被引用文献数

10 18

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The causal relationship between the inhibition of antibody production and liver injury induced by single doses of acetaminophen (APAP) was investigated in mice. The liver injury and antibody production were evaluated using the serum transaminase activity and the number of antibody forming cells against sheep red blood cells (SRBC), respectively. The relevance of APAP hepatotoxicity with inhibiting antibody production was elucidated in fasted and fed mice treated with a single oral administration of APAP. In fasted mice, the oral administration of APAP produced serious liver injury, while it was not the case in the fed mice. As the antibody production was measured under these conditions, APAP significantly depressed the antibody production in fed mice as well as in fasted mice. The rate of B220 positive cells in the splenocytes was significantly decreased by APAP administration in both the fasted and fed mice. Splenocytes proliferative responses following mitogenic stimulation with concanavalin A or lipopolysaccharide were inhibited by APAP. Moreover, APAP added directly to the splenocyte culture also inhibited the in vitro antibody-producing response to SRBC. These findings indicate that the APAP-induced depression of antibody production may not be a secondary response to APAP-hepatitis, but may be a primary response to APAP.

著者

Hiroyasu Sato Norihito Doki Masaaki Yokota Kenji Shimizu Shingo Yano

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.48, no.11, pp.903-908, 2015-11-20 (Released:2015-11-20)

参考文献数

13

被引用文献数

1

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A new optical resolution method is proposed in which one enantiomer of a racemic mixture is replaced with a tailor-made additive, and the displaced enantiomer is crystallized. DL-Aspartic acid (Asp) was examined as a model racemic compound. First, L-Asp crystallization was examined in the presence of L-asparagine (Asn) or D-Asn. The effect of Asn was chirality-specific; L-Asn specifically replaced some of the L-Asp in the crystal lattice and solid solutions of L-Asp with L-Asn formed. Secondly, DL-Asp crystallization was examined in the presence of L-Asn, and the obtained crystals were solid solutions of DL-Asp with L-Asn partially replacing L-Asp in the DL-Asp crystal lattice. Finally, crystallization of the L-Asp in the filtrate of the DL-Asp crystallization in the presence of L-Asn was examined. The obtained crystals were a mixture of solid solutions of L-Asp with L-Asn and solid solutions of DL-Asp with L-Asn. Moreover, when D-Asn was added to the DL-Asp crystallization, a mixture of solid solutions of D-Asp with D-Asn and solid solutions of DL-Asp with D-Asn was crystallized from the filtrate. These results show that racemic compounds could be resolved by the proposed method.