- 著者
- Kyung-Duk Min Sun-Young Kim Sung-il Cho
- 出版者
- The Japanese Society for Hygiene
- 雑誌
- Environmental Health and Preventive Medicine (ISSN:1342078X)
- 巻号頁・発行日
- vol.28, pp.48, 2023 (Released:2023-08-31)
- 参考文献数
- 42
- 被引用文献数
- 1
Background: The effect of ambient PM2.5 on the incidence of tuberculosis (TB) has been investigated in epidemiological studies. However, they did not separately study new and relapsed TB infection and focused on relatively short-term effects of PM2.5. In this regard, we examined the associations of long-term PM2.5 exposures with both new and relapsed TB incidences in South Korea, where the disease burden of TB is greatest among high-income countries.Methods: An area-level ecological study of 250 districts was conducted from 2015 to 2019. Age- and sex-standardized TB incidence ratios for each district and year were used as outcome variables, and their associations with PM2.5 concentrations for one to five-year average were examined. Negative binomial regression models incorporating spatiotemporal autocorrelation were employed using integrated nested Laplace approximations. Stratified analyses were conducted by type of TB (total, new, and relapsed cases).Results: Districts with higher PM2.5 concentrations tended to have significantly higher TB recurrence rate. The relative risks per 10 µg/m3 PM2.5 increase were 1.218 (95% credible interval 1.051–1.411), 1.260 (1.039–1.527) and 1.473 (1.015–2.137) using the two, three and five-year average PM2.5 exposures, respectively.Conclusions: The results imply that interventions for reducing air pollution might help prevent TB recurrence.
- 著者
- Joung-Soon KIM Hyun-Sul LIM Sung-Il CHO Hae-Kwan CHEONG Min-Kyung LIM
- 出版者
- National Institute of Occupational Safety and Health
- 雑誌
- Industrial Health (ISSN:00198366)
- 巻号頁・発行日
- vol.41, no.3, pp.149-157, 2003 (Released:2007-03-29)
- 参考文献数
- 6
- 被引用文献数
- 63 86
In order to determine whether Agent Orange exposure was associated with increased frequency of medical problems, we conducted a cross-sectional epidemiologic study of Korean veterans during 1995-1996. 1, 224 Vietnam and 154 non-Vietnam veterans were included in the study. Exposure to Agent Orange was assessed by structured in-depth interview on the participants' history of service in Vietnam. Health outcomes were assessed by a standardized comprehensive clinical investigation by a group of clinical specialists. The differences in the prevalence of various medical diagnoses were assessed by Cochran-Mantel-Haenszel chi-square tests comparing the exposure levels of Vietnam veterans, adjusting for age. Multiple logistic regression was performed to estimate the effect of “service in Vietnam” adjusting for age, smoking, alcohol, body mass index, education, and marital status. Vietnam veterans had an increased frequency of eczema (odds ratio [OR]=6.54), radiculopathy (OR=3.98), diabetes (OR=2.69), peripheral neuropathy (OR=2.39), and hypertension (OR=2.29), compared to non-Vietnam veterans, adjusting for potential confounders. In addition, higher levels of exposure among Vietnam veterans were associated with increased frequency of ischemic heart disease (p<0.01), valvular heart disease (p<0.01), and retinopathy (p<0.01). We conclude that exposure to Agent Orange is associated with various health impacts in Korean Vietnam veterans.
- 著者
- Yongho Jee Mikyung Ryu In Sun Ryou Joung Hwan Back Sung-il Cho Seung Sik Hwang
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- vol.33, no.10, pp.514-520, 2023-10-05 (Released:2023-10-05)
- 参考文献数
- 33
Background: The prevalence of overweight and obesity are well known risk factors of atherosclerotic cardiovascular disease (ASCVD). We aimed to examine the association between body mass index (BMI) and ASCVD over a 23-year follow-up in young adults. We also qualified how much of the effects of obesity on ASCVD were mediated through blood pressure, cholesterol, and glucose.Methods: Data are from the Korean Life Course Health Study, a cohort study of 226,955 Korean young adults aged 20–39. At baseline, the participants undertook routine health assessments where their BMI was measured in 1992–1994; and the metabolic mediators including systolic blood pressure (SBP), fasting serum glucose (FSG), and total cholesterol (TC) were re-measured in 2002–2004. The main outcomes of the study include incident events of ischemic heart disease (IHD), stroke, and ASCVD between 2005 and 2015. Cox proportional model was used to calculate adjusted hazard ratios (HRs) for ASCVD.Results: In both men and women, the direct effect of BMI on ASCVD was greater than the indirect effect. The percentage of excess HR of BMI mediated by all of the metabolic mediators, including SBP, FSG, and TC, was 45.7% for stroke and 18.7% for IHD in men and 27.5% for stroke and 17.6% for IHD in women.Conclusion: High BMI in young adults increases the risk of metabolic mediators in their middle age, and metabolic mediators explain the adverse effects of high BMI on stroke risk than IHD risk.