著者

TAKAHASHI K

出版者

Elsevier Inc.

雑誌

Cell (ISSN:00928674)

巻号頁・発行日

vol.126, no.4, pp.663-676, 2006-08-25

被引用文献数

157 20074

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This article is related to the Nobel Prize in Physiology or Medicine 2012Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.

著者

Yoshimi R. Tsukazaki A. Kozuka Y. Falson J. Takahashi K. S. Checkelsky J. G. Nagaosa N. Kawasaki M. Tokura Y.

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

no.6, 2015-04-14

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The three-dimensional topological insulator is a novel state of matter characterized by two-dimensional metallic Dirac states on its surface. To verify the topological nature of the surface states, Bi-based chalcogenides such as Bi2Se3, Bi2Te3, Sb2Te3 and their combined/mixed compounds have been intensively studied. Here, we report the realization of the quantum Hall effect on the surface Dirac states in (Bi1−xSbx)2Te3 films. With electrostatic gate-tuning of the Fermi level in the bulk band gap under magnetic fields, the quantum Hall states with filling factor ±1 are resolved. Furthermore, the appearance of a quantum Hall plateau at filling factor zero reflects a pseudo-spin Hall insulator state when the Fermi level is tuned in between the energy levels of the non-degenerate top and bottom surface Dirac points. The observation of the quantum Hall effect in three-dimensional topological insulator films may pave a way toward topological insulator-based electronics.UTokyo Research掲載「トポロジカル絶縁体の表面ディラック状態の量子化を実証」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/observation-of-quantization-in-surface-dirac-states-of-topological-insulator.html

著者

Acharya BS Actis M Aghajani T Agnetta G Aguilar J Aharonian F Ajello M Akhperjanian A Alcubierre M Aleksic J Alfaro R Aliu E Allafort AJ Allan D Allekotte I Amato E Anderson J Anguner EO Antonelli LA Antoranz P Aravantinos A Arlen T Armstrong T Arnaldi H Arrabito L Asano K Ashton T Asorey HG Awane Y Baba H Babic A Baby N Bahr J Bais A Baixeras C Bajtlik S Balbo M Balis D Balkowski C Bamba A Bandiera R Barber A Barbier C Barcelo M Barnacka A Barnstedt J de Almeida UB Barrio JA Basili A Basso S Bastieri D Bauer C Baushev A Becerra J Becherini Y Bechtol KC Tjus JB Beckmann V Bednarek W Behera B Belluso M Benbow W Berdugo J Berger K Bernard F Bernardino T Bernlohr K Bhat N Bhattacharyya S Bigongiari C Biland A Billotta S Bird T Birsin E Bissaldi E Biteau J Bitossi M Blake S Bigas OB Blasi P Bobkov A Boccone V Boettcher M Bogacz L Bogart J Bogdan M Boisson C Gargallo JB Bolmont J Bonanno G Bonardi A Bonev T Bonifacio P Bonnoli G Bordas P Borgland A Borkowski J Bose R Botner O Bottani A 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Gall D Gallant Y Gamez-Garcia J Garcia B Lopez RG Gardiol D Garrido D Garrido L Gascon D Gaug M Gaweda J Gebremedhin L Geffroy N Gerard L Ghedina A Ghigo M Giannakaki E Gianotti F Giarrusso S Giavitto G Giebels B Gika V Giommi P Girard N Giro E Giuliani A Glanzman T Glicenstein JF Godinovic N Golev V Berisso MG Gomez-Ortega J Gonzalez MM Gonzalez A Gonzalez F Munoz AG Gothe KS Gougerot M Graciani R Grandi P Granena F Granot J Grasseau G Gredig R Green A Greenshaw T Gregoire T Grimm O Grube J Grudzinska M Gruev V Grunewald S Grygorczuk J Guarino V Gunji S Gyuk G Hadasch D Hagiwara R Hahn J Hakansson N Hallgren A Heras NH Hara S Hardcastle MJ Harris J Hassan T Hatanaka K Haubold T Haupt A Hayakawa T Hayashida M Heller R Henault F Henri G Hermann G Hermel R Herrero A Hidaka N Hinton J Hoffmann D Hofmann W Hofverberg P Holder J Horns D Horville D Houles J Hrabovsky M Hrupec D Huan H Huber B Huet JM Hughes G Humensky TB Huovelin J Ibarra A Illa JM Impiombato D Incorvaia S Inoue S Inoue Y 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Lieunard B Lindfors E Liolios A Lipniacka A Lockart H Lohse T Lombardi S Lopatin A Lopez M Lopez-Coto R Lopez-Oramas A Lorca A Lorenz E Lubinski P Lucarelli F Ludecke H Ludwin J Luque-Escamilla PL Lustermann W Luz O Lyard E Maccarone MC Maccarone TJ Madejski GM Madhavan A Mahabir M Maier G Majumdar P Malaguti G Maltezos S Manalaysay A Mancilla A Mandat D Maneva G Mangano A Manigot P Mannheim K Manthos I Maragos N Marcowith A Mariotti M Marisaldi M Markoff S Marszalek A Martens C Marti J Martin JM Martin P Martinez G Martinez F Martinez M Masserot A Mastichiadis A Mathieu A Matsumoto H Mattana F Mattiazzo S Maurin G Maxfield S Maya J Mazin D Mc Comb L McCubbin N McHardy I McKay R Medina C Melioli C Melkumyan D Mereghetti S Mertsch P Meucci M Michalowski J Micolon P Mihailidis A Mineo T Minuti M Mirabal N Mirabel F Miranda JM Mirzoyan R Mizuno T Moal B Moderski R Mognet I Molinari E Molinaro M Montaruli T Monteiro I Moore P Olaizola AM Mordalska M Morello C Mori K Mottez F Moudden Y Moulin E Mrusek I Mukherjee R Munar-Adrover P Muraishi H Murase K Murphy A Nagataki S Naito T Nakajima D Nakamori T Nakayama K Naumann C Naumann D Naumann-Godo M Nayman P Nedbal D Neise D Nellen L Neustroev V Neyroud N Nicastro L Nicolau-Kuklinski J Niedzwiecki A Niemiec J Nieto D Nikolaidis A Nishijima K Nolan S Northrop R Nosek D Nowak N Nozato A O'Brien P Ohira Y Ohishi M Ohm S Ohoka H Okuda T Okumura A Olive JF Ong RA Orito R Orr M Osborne J Ostrowski M Otero LA Otte N Ovcharov E Oya I Ozieblo A Padilla L Paiano S Paillot D Paizis A Palanque S Palatka M Pallota J Panagiotidis K Panazol JL Paneque D Panter M Paoletti R Papayannis A Papyan G Paredes JM Pareschi G Parks G Parraud JM Parsons D Arribas MP Pech M Pedaletti G Pelassa V Pelat D Perez MDC Persic M Petrucci PO Peyaud B Pichel A Pita S Pizzolato F Platos L Platzer R Pogosyan L Pohl M Pojmanski G Ponz JD Potter W Poutanen J Prandini E Prast J Preece R Profeti F Prokoph H Prouza M Proyetti M Puerto-Gimenez I Puhlhofer G Puljak I Punch M Pyziol R Quel EJ Quinn J Quirrenbach A Racero E Rajda PJ Ramon P Rando R Rannot RC Rataj M Raue M Reardon P Reimann O Reimer A Reimer O Reitberger K Renaud M Renner S Reville B Rhode W Ribo M Ribordy M Richer MG Rico J Ridky J Rieger F Ringegni P Ripken J Ristori PR Riviere A Rivoire S Rob L Roeser U Rohlfs R Rojas G Romano P Romaszkan W Romero GE Rosen S Lees SR Ross D Rouaix G Rousselle J Rousselle S Rovero AC Roy F Royer S Rudak B Rulten C Rupinski M Russo F Ryde F Sacco B Saemann EO Saggion A Safiakian V Saito K Saito T Saito Y Sakaki N Sakonaka R Salini A Sanchez F Sanchez-Conde M Sandoval A Sandaker H Sant'Ambrogio E Santangelo A Santos EM Sanuy A Sapozhnikov L Sarkar S Sartore N Sasaki H Satalecka K Sawada M Scalzotto V Scapin V Scarcioffolo M Schafer J Schanz T Schlenstedt S Schlickeiser R Schmidt T Schmoll J Schovanek P Schroedter M Schultz C Schultze J Schulz A Schure K Schwab T Schwanke U Schwarz J Schwarzburg S Schweizer T Schwemmer S Segreto A Seiradakis JH 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Troyano I Tsinganos K Ueno H Umehara K Upadhya SS Usher T Uslenghi M Valdes-Galicia JF Vallania P Vallejo G van Driel W van Eldik C Vandenbrouke J Vanderwalt J Vankov H Vasileiadis G Vassiliev V Veberic D Vegas I Vercellone S Vergani S Veyssiere C Vialle JP Viana A Videla M Vincent P Vincent S Vink J Vlahakis N Vlahos L Vogler P Vollhardt A von Gunten HP Vorobiov S Vuerli C Waegebaert V Wagner R Wagner RG Wagner S Wakely SP Walter R Walther T Warda K Warwick R Wawer P Wawrzaszek R Webb N Wegner P Weinstein A Weitzel Q Welsing R Werner M Wetteskind H White R Wierzcholska A Wiesand S Wilkinson M Williams DA Willingale R Winiarski K Wischnewski R Wisniewski L Wood M Wornlein A Xiong Q Yadav KK Yamamoto H Yamamoto T Yamazaki R Yanagita S Yebras JM Yelos D Yoshida A Yoshida T Yoshikoshi T Zabalza V Zacharias M Zajczyk A Zanin R Zdziarski A Zech A Zhao A Zhou X Zietara K Ziolkowski J Ziolkowski P Zitelli V Zurbach C Zychowski P

雑誌

ASTROPARTICLE PHYSICS (ISSN:09276505)

巻号頁・発行日

vol.43, pp.3-18, 2013