著者

Walter R. Frontera

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.7, pp.20220044, 2022 (Released:2022-09-03)

参考文献数

84

被引用文献数

4

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The 20th and 21st centuries have witnessed a substantial increase in human life expectancy and in the number of men and women aged 60 years and older. Aging is associated with a large number of health conditions, including sarcopenia, which has been the subject of important research in the past 30 years. Sarcopenia is characterized by an age-related loss of muscle mass, weakness, and impaired physical performance. The condition can be diagnosed with a combination of measurements of these three elements. The precise definition of sarcopenia and the selection of optimal assessment methods have changed significantly in the past 20 years; nonetheless, the prevalence of sarcopenia in the general older population is in the range of 5–15%. Molecular and cellular events at the muscle cell level impact the size and quality of muscles (force adjusted for size). The active and passive mechanical properties of single muscle fibers are altered by changes in the structure and function of various cellular elements. Systemic factors such as inflammation, loss of hormonal influence, and deleterious lifestyle choices also contribute to sarcopenia. The consequences of sarcopenia include many adverse effects such as impairments in activities of daily living, falls, loss of independence, and increased mortality. Several rehabilitative interventions have been tested, and the safest and most effective is the use of progressive resistance exercise. An increase in dietary protein intake has synergistic effects. Future research should focus on a consensus definition of sarcopenia, identification of the best assessment methods, understanding of biological mechanisms, and testing of innovative interventions.

著者

Acharya BS Actis M Aghajani T Agnetta G Aguilar J Aharonian F Ajello M Akhperjanian A Alcubierre M Aleksic J Alfaro R Aliu E Allafort AJ Allan D Allekotte I Amato E Anderson J Anguner EO Antonelli LA Antoranz P Aravantinos A Arlen T Armstrong T Arnaldi H Arrabito L Asano K Ashton T Asorey HG Awane Y Baba H Babic A Baby N Bahr J Bais A Baixeras C Bajtlik S Balbo M Balis D Balkowski C Bamba A Bandiera R Barber A Barbier C Barcelo M Barnacka A Barnstedt J de Almeida UB Barrio JA Basili A Basso S Bastieri D Bauer C Baushev A Becerra J Becherini Y Bechtol KC Tjus JB Beckmann V Bednarek W Behera B Belluso M Benbow W Berdugo J Berger K Bernard F Bernardino T Bernlohr K Bhat N Bhattacharyya S Bigongiari C Biland A Billotta S Bird T Birsin E Bissaldi E Biteau J Bitossi M Blake S Bigas OB Blasi P Bobkov A Boccone V Boettcher M Bogacz L Bogart J Bogdan M Boisson C Gargallo JB Bolmont J Bonanno G Bonardi A Bonev T Bonifacio P Bonnoli G Bordas P Borgland A Borkowski J Bose R Botner O Bottani A Bouchet L Bourgeat M Boutonnet C Bouvier A Brau-Nogue S Braun I Bretz T Briggs M Bringmann T Brook P Brun P Brunetti L Buanes T Buckley J Buehler R Bugaev V Bulgarelli A Bulik T Busetto G Buson S Byrum K Cailles M Cameron R Camprecios J Canestrari R Cantu S Capalbi M Caraveo P Carmona E Carosi A Carr J Carton PH Casanova S Casiraghi M Catalano O Cavazzani S Cazaux S Cerruti M Chabanne E Chadwick P Champion C Chen A Chiang J Chiappetti L Chikawa M Chitnis VR Chollet F Chudoba J Cieslar M Cillis A Cohen-Tanugi J Colafrancesco S Colin P Calome J Colonges S Compin M Conconi P Conforti V Connaughton V Conrad J Contreras JL Coppi P Corona P Corti D Cortina J Cossio L Costantini H Cotter G Courty B Couturier S Covino S Crimi G Criswell SJ Croston J Cusumano G Dafonseca M Dale O Daniel M Darling J Davids I Dazzi F De Angelis A De Caprio V De Frondat F Dal Pino EMD de la Calle I De La Vega GA Lopez RD De Lotto B De Luca A Neto JRTD de Naurois M de Oliveira Y Wilhelmi ED de Souza V Decerprit G Decock G Deil C Delagnes E Deleglise G Delgado C Della Volpe D Demange P Depaola G Dettlaff A Di Paola A Di Pierro F Diaz C Dick J Dickherber R Dickinson H Diez-Blanco V Digel S Dimitrov D Disset G Djannati-Atai A Doert M Dohmke M Domainko W Prester DD Donat A Dorner D Doro M Dournaux JL Drake G Dravins D Drury L Dubois F Dubois R Dubus G Dufour C Dumas D Dumm J Durand D Dyks J Dyrda M Ebr J Edy E Egberts K Eger P Einecke S Eleftheriadis C Elles S Emmanoulopoulos D Engelhaupt D Enomoto R Ernenwein JP Errando M Etchegoyen A Evans P Falcone A Fantinel D Farakos K Farnier C Fasola G Favill B Fede E Federici S Fegan S Feinstein F Ferenc D Ferrando P Fesquet M Fiasson A Fillin-Martino E Fink D Finley C Finley JP Fiorini M Curcoll RF Flores H Florin D Focke W Fohr C Fokitis E Font L Fontaine G Fornasa M Forster A Fortson L Fouque N Franckowiak A Fransson C Fraser G Frei R Albuquerque IFM Fresnillo L Fruck C Fujita Y Fukazawa Y Fukui Y Funk S Gabele W Gabici S Gabriele R Gadola A Galante N Gall D Gallant Y Gamez-Garcia J Garcia B Lopez RG Gardiol D Garrido D Garrido L Gascon D Gaug M Gaweda J Gebremedhin L Geffroy N Gerard L Ghedina A Ghigo M Giannakaki E Gianotti F Giarrusso S Giavitto G Giebels B Gika V Giommi P Girard N Giro E Giuliani A Glanzman T Glicenstein JF Godinovic N Golev V Berisso MG Gomez-Ortega J Gonzalez MM Gonzalez A Gonzalez F Munoz AG Gothe KS Gougerot M Graciani R Grandi P Granena F Granot J Grasseau G Gredig R Green A Greenshaw T Gregoire T Grimm O Grube J Grudzinska M Gruev V Grunewald S Grygorczuk J Guarino V Gunji S Gyuk G Hadasch D Hagiwara R Hahn J Hakansson N Hallgren A Heras NH Hara S Hardcastle MJ Harris J Hassan T Hatanaka K Haubold T Haupt A Hayakawa T Hayashida M Heller R Henault F Henri G Hermann G Hermel R Herrero A Hidaka N Hinton J Hoffmann D Hofmann W Hofverberg P Holder J Horns D Horville D Houles J Hrabovsky M Hrupec D Huan H Huber B Huet JM Hughes G Humensky TB Huovelin J Ibarra A Illa JM Impiombato D Incorvaia S Inoue S Inoue Y Ioka K Ismailova E Jablonski C Jacholkowska A Jamrozy M Janiak M Jean P Jeanney C Jimenez JJ Jogler T Johnson T Journet L Juffroy C Jung I Kaaret P Kabuki S Kagaya M Kakuwa J Kalkuhl C Kankanyan R Karastergiou A Karcher K Karczewski M Karkar S Kasperek A Kastana D Katagiri H Kataoka J Katarzynski K Katz U Kawanaka N Kellner-Leidel B Kelly H Kendziorra E Khelifi B Kieda DB Kifune T Kihm T Kishimoto T Kitamoto K Kluzniak W Knapic C Knapp J Knodlseder J Kock F Kocot J Kodani K Kohne JH Kohri K Kokkotas K Kolitzus D Komin N Kominis I Konno Y Koppel H Korohoda P Kosack K Koss G Kossakowski R Kostka P Koul R Kowal G Koyama S Koziol J Krahenbuhl T Krause J Krawzcynski H Krennrich F Krepps A Kretzschmann A Krobot R Krueger P Kubo H Kudryavtsev VA Kushida J Kuznetsov A La Barbera A La Palombara N La Parola V La Rosa G Lacombe K Lamanna G Lande J Languignon D Lapington J Laporte P Lavalley C Le Flour T Le Padellec A Lee SH Lee WH de Oliveira MAL Lelas D Lenain JP Leopold DJ Lerch T Lessio L Lieunard B Lindfors E Liolios A Lipniacka A Lockart H Lohse T Lombardi S Lopatin A Lopez M Lopez-Coto R Lopez-Oramas A Lorca A Lorenz E Lubinski P Lucarelli F Ludecke H Ludwin J Luque-Escamilla PL Lustermann W Luz O Lyard E Maccarone MC Maccarone TJ Madejski GM Madhavan A Mahabir M Maier G Majumdar P Malaguti G Maltezos S Manalaysay A Mancilla A Mandat D Maneva G Mangano A Manigot P Mannheim K Manthos I Maragos N Marcowith A Mariotti M Marisaldi M Markoff S Marszalek A Martens C Marti J Martin JM Martin P Martinez G Martinez F Martinez M Masserot A Mastichiadis A Mathieu A Matsumoto H Mattana F Mattiazzo S Maurin G Maxfield S Maya J Mazin D Mc Comb L McCubbin N McHardy I McKay R Medina C Melioli C Melkumyan D Mereghetti S Mertsch P Meucci M Michalowski J Micolon P Mihailidis A Mineo T Minuti M Mirabal N Mirabel F Miranda JM Mirzoyan R Mizuno T Moal B Moderski R Mognet I Molinari E Molinaro M Montaruli T Monteiro I Moore P Olaizola AM Mordalska M Morello C Mori K Mottez F Moudden Y Moulin E Mrusek I Mukherjee R Munar-Adrover P Muraishi H Murase K Murphy A Nagataki S Naito T Nakajima D Nakamori T Nakayama K Naumann C Naumann D Naumann-Godo M Nayman P Nedbal D Neise D Nellen L Neustroev V Neyroud N Nicastro L Nicolau-Kuklinski J Niedzwiecki A Niemiec J Nieto D Nikolaidis A Nishijima K Nolan S Northrop R Nosek D Nowak N Nozato A O'Brien P Ohira Y Ohishi M Ohm S Ohoka H Okuda T Okumura A Olive JF Ong RA Orito R Orr M Osborne J Ostrowski M Otero LA Otte N Ovcharov E Oya I Ozieblo A Padilla L Paiano S Paillot D Paizis A Palanque S Palatka M Pallota J Panagiotidis K Panazol JL Paneque D Panter M Paoletti R Papayannis A Papyan G Paredes JM Pareschi G Parks G Parraud JM Parsons D Arribas MP Pech M Pedaletti G Pelassa V Pelat D Perez MDC Persic M Petrucci PO Peyaud B Pichel A Pita S Pizzolato F Platos L Platzer R Pogosyan L Pohl M Pojmanski G Ponz JD Potter W Poutanen J Prandini E Prast J Preece R Profeti F Prokoph H Prouza M Proyetti M Puerto-Gimenez I Puhlhofer G Puljak I Punch M Pyziol R Quel EJ Quinn J Quirrenbach A Racero E Rajda PJ Ramon P Rando R Rannot RC Rataj M Raue M Reardon P Reimann O Reimer A Reimer O Reitberger K Renaud M Renner S Reville B Rhode W Ribo M Ribordy M Richer MG Rico J Ridky J Rieger F Ringegni P Ripken J Ristori PR Riviere A Rivoire S Rob L Roeser U Rohlfs R Rojas G Romano P Romaszkan W Romero GE Rosen S Lees SR Ross D Rouaix G Rousselle J Rousselle S Rovero AC Roy F Royer S Rudak B Rulten C Rupinski M Russo F Ryde F Sacco B Saemann EO Saggion A Safiakian V Saito K Saito T Saito Y Sakaki N Sakonaka R Salini A Sanchez F Sanchez-Conde M Sandoval A Sandaker H Sant'Ambrogio E Santangelo A Santos EM Sanuy A Sapozhnikov L Sarkar S Sartore N Sasaki H Satalecka K Sawada M Scalzotto V Scapin V Scarcioffolo M Schafer J Schanz T Schlenstedt S Schlickeiser R Schmidt T Schmoll J Schovanek P Schroedter M Schultz C Schultze J Schulz A Schure K Schwab T Schwanke U Schwarz J Schwarzburg S Schweizer T Schwemmer S Segreto A Seiradakis JH Sembroski GH Seweryn K Sharma M Shayduk M Shellard RC Shi J Shibata T Shibuya A Shum E Sidoli L Sidz M Sieiro J Sikora M Silk J Sillanpaa A Singh BB Sitarek J Skole C Smareglia R Smith A Smith D Smith J Smith N Sobczynska D Sol H Sottile G Sowinski M Spanier F Spiga D Spyrou S Stamatescu V Stamerra A Starling R Stawarz L Steenkamp R Stegmann C Steiner S Stergioulas N Sternberger R Sterzel M Stinzing F Stodulski M Straumann U Strazzeri E Stringhetti L Suarez A Suchenek M Sugawara R Sulanke KH Sun S Supanitsky AD Suric T Sutcliffe P Sykes J Szanecki M Szepieniec T Szostek A Tagliaferri G Tajima H Takahashi H Takahashi K Takalo L Takami H Talbot C Tammi J Tanaka M Tanaka S Tasan J Tavani M Tavernet JP Tejedor LA Telezhinsky I Temnikov P Tenzer C Terada Y Terrier R Teshima M Testa V Tezier D Thuermann D Tibaldo L Tibolla O Tiengo A Tluczykont M Peixoto CJT Tokanai F Tokarz M Toma K Torii K Tornikoski M Torres DF Torres M Tosti G Totani T Toussenel C Tovmassian G Travnicek P Trifoglio M Troyano I Tsinganos K Ueno H Umehara K Upadhya SS Usher T Uslenghi M Valdes-Galicia JF Vallania P Vallejo G van Driel W van Eldik C Vandenbrouke J Vanderwalt J Vankov H Vasileiadis G Vassiliev V Veberic D Vegas I Vercellone S Vergani S Veyssiere C Vialle JP Viana A Videla M Vincent P Vincent S Vink J Vlahakis N Vlahos L Vogler P Vollhardt A von Gunten HP Vorobiov S Vuerli C Waegebaert V Wagner R Wagner RG Wagner S Wakely SP Walter R Walther T Warda K Warwick R Wawer P Wawrzaszek R Webb N Wegner P Weinstein A Weitzel Q Welsing R Werner M Wetteskind H White R Wierzcholska A Wiesand S Wilkinson M Williams DA Willingale R Winiarski K Wischnewski R Wisniewski L Wood M Wornlein A Xiong Q Yadav KK Yamamoto H Yamamoto T Yamazaki R Yanagita S Yebras JM Yelos D Yoshida A Yoshida T Yoshikoshi T Zabalza V Zacharias M Zajczyk A Zanin R Zdziarski A Zech A Zhao A Zhou X Zietara K Ziolkowski J Ziolkowski P Zitelli V Zurbach C Zychowski P

雑誌

ASTROPARTICLE PHYSICS (ISSN:09276505)

巻号頁・発行日

vol.43, pp.3-18, 2013