- 著者
- Lei GONG Toshiyuki YAMAMOTO Takayuki MORIKAWA
- 出版者
- Eastern Asia Society for Transportation Studies
- 雑誌
- Asian Transport Studies (ISSN:21855560)
- 巻号頁・発行日
- vol.4, no.1, pp.114-128, 2016 (Released:2016-03-01)
- 参考文献数
- 27
Ever since global positioning system (GPS) modules have been attached to smart phones, much research has focused on how to obtain personal trip (PT) information from them. One of the challenges is identifying activity type (or inferring the purpose of the trip) from these continuous GPS data. This paper focuses on obtaining the type of activity using several machine learning methods and comparing the results. The comparison is implemented from the perspective of accuracy and time cost in the phases of data training and prediction. After applying four machine learning methods to the data set obtained from 30 individuals in Nagoya, Japan, a classification tree method demonstrates superiority over support vector machine (SVM), neural network (NN), and discriminant analysis methods.
- 著者
- Shinichi Goto Takayuki Morikawa Akiko Kubo Keiyo Takubo Keiichi Fukuda Mayumi Kajimura Makoto Suematsu
- 出版者
- SOCIETY FOR FREE RADICAL RESEARCH JAPAN
- 雑誌
- Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
- 巻号頁・発行日
- vol.63, no.1, pp.70-79, 2018 (Released:2018-07-01)
- 参考文献数
- 30
- 被引用文献数
- 6
Carbon monoxide-generating heme oxygenase-2 is expressed in neurons and plays a crucial role for regulating hypoxic vasodilation through mechanisms unlocking carbon monoxide-dependent inhibition of H2S-generating cystathionine β-synthase expressed in astrocytes. This study aims to examine whether heme oxygenase-2 plays a protective role in mice against stroke. Focal ischemia was induced by middle cerebral artery occlusion. Regional differences in metabolites among ipsilateral and contralateral hemispheres were analysed by quantitative imaging mass spectrometry equipped with an image-processing platform to optimize comparison of local metabolite contents among different animals. Under normoxia, blood flow velocity in precapillary arterioles were significantly elevated in heme oxygenase-2-null mice vs controls, while metabolic intermediates of central carbon metabolism and glutamate synthesis were elevated in the brain of heme oxygenase-2-null mice, suggesting greater metabolic demands to induce hyperemia in these mice. In response to focal ischemia, heme oxygenase-2-null mice exhibited greater regions of ischemic core that coincide with notable decreases in energy metabolism in the contralateral hemisphere as well as in penumbra. In conclusion, these findings suggest that heme oxygenase-2 is involved in mechanisms by which not only protects against compromised energy metabolism of the ipsilateral hemisphere but also ameliorates transhemispheric diaschisis of the contralateral hemisphere in ischemic brain.