- 著者
- Hironori Imano Hiroyasu Iso Akihiko Kitamura Kazumasa Yamagishi Mina Hayama-Terada Isao Muraki Takeo Okada Mitsumasa Umesawa Tetsuya Ohira Tomoko Sankai Renzhe Cui Takeshi Tanigawa Masahiko Kiyama on behalf of the CIRCS Investigators
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-17-0950, (Released:2018-02-14)
- 参考文献数
- 44
- 被引用文献数
- 6
Background:The effect of postprandial glucose on the risk of cardiovascular disease has been emphasized, but it is controversial whether nonfasting glucose is related to incident stroke and its types.Methods and Results:We investigated the associations of nonfasting glucose with incident stroke and its types among 7,198 participants aged 40–74 years from the Circulatory Risk in Communities Study, enrolled in 1995–2000. We estimated multivariable hazard ratios (HR) using Cox proportional hazard models. Over a median follow-up of 14.1 years, 291 cases of total stroke (ischemic strokes: 191 including 109 lacunar infarctions) were identified. Nonfasting glucose concentration was associated with greater risk of incident total stroke, ischemic stroke and lacunar infarction when modeled categorically (for prediabetic type: 7.8–11.0 mmol/L vs. normal type: <7.8 mmol/L among all subjects, HR for lacunar infarction was 2.02, 95% confidence interval (CI): 1.19, 3.43) or continuously (per one standard deviation increment among all subjects, HR for lacunar infarction was 1.29, 95% CI: 1.15, 1.45). Diabetic type showed similar results. Population attributable fractions of nonfasting hyperglycemia were 13.2% for ischemic stroke and 17.4% for lacunar infarction.Conclusions:Nonfasting glucose concentration, either as a diagnosis of prediabetic and diabetic types or as a continuous variable, proved to be an independent predictor significantly attributed to incident total stroke, especially ischemic stroke and lacunar infarction, in the general population.
- 著者
- Yoko Watanabe Isao Saito Ikuyo Henmi Kana Yoshimura Hirotatsu Maruyama Kanako Yamauchi Tatsuhiro Matsuo Tadahiro Kato Takeshi Tanigawa Taro Kishida Yasuhiko Asada
- 出版者
- THE JAPANESE ASSOCIATION OF RURAL MEDICINE
- 雑誌
- Journal of Rural Medicine (ISSN:1880487X)
- 巻号頁・発行日
- pp.2887, (Released:2014-06-17)
- 被引用文献数
- 47 68
Objectives: Despite the fact that the total energy intake of Japanese people has decreased, the percentage of obese people has increased. This suggests that the timing of meals is related to obesity. The purpose of the study was to investigate the relationship between the timing of meals and obesity, based on analyses of physical measurements, serum biochemical markers, nutrient intake, and lifestyle factors in the context of Chrononutrition.Participants and Methods: We analyzed data derived from 766 residents of Toon City (286 males and 480 females) aged 30 to 79 years who underwent detailed medical examinations between 2011 and 2013. These medical examinations included. (1) physical measurements (waist circumference, blood pressure, etc.); (2) serum biochemical markers (total cholesterol, etc.); (3) a detailed questionnaire concerning lifestyle factors such as family structure and daily habits (22 issues), exercise and eating habits (28 issues), alcohol intake and smoking habits; (4) a food frequency questionnaire based on food groups (FFQg);and (5) a questionnaire concerning the times at which meals and snacks are consumed.Results: The values for body mass index (BMI) and waist circumference were higher for participants who ate dinner less than three hours before bedtime (<3-h group) than those who ate more than three hours before bedtime (>3-h group). The Chi-square test showed that there was a significant difference in eating habits, e.g., eating snacks, eating snacks at night, having dinner after 8 p.m., and having dinner after 9 p.m., between the <3-h group and the >3-h group. Multiple linear regression analysis showed that skipping breakfast significantly influenced both waist circumference (β = 5.271) and BMI (β = 1.440) and that eating dinner <3-h before going to bed only influenced BMI (β = 0.581).Conclusion: Skipping breakfast had a greater influence on both waist circumference and BMI than eating dinner <3-h before going to bed.
- 著者
- Satomi Ikeda Ai Ikeda Kazumasa Yamagishi Miyuki Hori Sachimi Kubo Mizuki Sata Chika Okada Mitsumasa Umesawa Tomoko Sankai Akihiko Kitamura Masahiko Kiyama Tetsuya Ohira Takeshi Tanigawa Hiroyasu Iso
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- pp.JE20190140, (Released:2020-02-22)
- 参考文献数
- 35
- 被引用文献数
- 6
Background. The frequency of laughter has been associated with cardiovascular disease and related biomarkers, but no previous studies have examined association between laughter and changes in blood pressure levels. We therefore sought to identify temporal relationships between frequency of laughter in daily life and systolic and diastolic blood pressure changes in participants from 2010 to 2014.Methods. Participants were 554 men and 887 women aged 40-74 years who answered self-administered questionnaire quantifying frequency of laughter at baseline. We measured participant blood pressure levels twice using automated sphygmomanometers for each year from 2010 to 2014. The associations between laughter and changes in blood pressure over time were analyzed using linear mixed-effect models.Results. There was no significant difference in blood pressure according to frequency of laughter at baseline in either sex. Men with frequency of laughter 1 to 3 per month or almost never had significantly increased systolic and diastolic blood pressure levels over four-year period (time-dependent difference (95% CI): 0.96 mmHg (-0.2, 1.8); p=0.05). Changes in blood pressure associated with infrequent laughter (i.e., 1 to 3 per month or almost never) were evident in men without antihypertensive medication use over four years (0.82 mmHg (0.1, 1.5); p=0.02) and men who were current drinkers at baseline (1.29 mmHg (-0.1, 2.3); p=0.04). No significant difference was found between frequency of laughter and systolic (0.23mmHg (-1.0, 1.5); p=0.72) and diastolic (-0.07mmHg (-0.8, 0.7); p=0.86) blood pressure changes in women.Conclusions. Infrequent laughter was associated with long-term blood pressure increment among middle-aged men.
- 著者
- Mari Tanaka Hironori Imano Yasuhiko Kubota Kazumasa Yamagishi Mitsumasa Umesawa Isao Muraki Renzhe Cui Mina Hayama-Terada Yuji Shimizu Takeo Okada Tetsuya Ohira Tomoko Sankai Takeshi Tanigawa Shinichi Sato Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso and the CIRCS Investigators
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- pp.54064, (Released:2020-06-10)
- 参考文献数
- 30
- 被引用文献数
- 11
Aim: This study aimed to investigate the association between the serum high-sensitivity C-reactive protein (hs-CRP) levels and incident atrial fibrillation risk in the general Japanese population, who have lower hs-CRP levels than the Western population, and assess whether the association is modified by sex, overweight, hypertension, and smoking status. Methods: We conducted a prospective study in 6517 Japanese men and women aged 40–79 years without atrial fibrillation at baseline and enrolled in the Circulatory Risk in Communities Study (2002–2008). The hs-CRP levels were measured using the latex particle-enhanced immunonephelometric assay. Atrial fibrillation was identified using standard 12-lead electrocardiograms and information on physician-diagnosed atrial fibrillation history from the follow-up surveys. We used a Cox proportional hazard regression stratified by community. Results: During a median follow-up of 11 years, 127 new cases of atrial fibrillation (74 and 53 cases among men and women, respectively) were found. Compared to the lowest quintile of hs-CRP levels, the multivariable hazard ratios (95% confidence intervals) were 2.54 (1.17–5.50), 2.28 (1.06–4.93), 2.92 (1.37–6.23), and 2.77 (1.30–5.91) for the second, third, fourth, and fifth (highest) quintiles, respectively. There was no significant effect modification by sex, overweight, hypertension, and smoking status (P for interaction >0.05). Conclusions: Elevated hs-CRP levels were significantly associated with increased risk of atrial fibrillation in the Japanese population. The association of hs-CRP levels with incident atrial fibrillation did not vary according to sex, overweight, hypertension status, or smoking status.
- 著者
- Hiroko Tobari Kazumasa Yamagishi Hiroyuki Noda Takeshi Tanigawa Hiroyasu Iso
- 出版者
- Japan Society for Occupational Health
- 雑誌
- Journal of Occupational Health (ISSN:13419145)
- 巻号頁・発行日
- vol.51, no.4, pp.323-331, 2009 (Released:2009-08-12)
- 参考文献数
- 38
- 被引用文献数
- 3
Objectives: Prevention of horse-related injuries is considered difficult because horse behavior is unpredictable. Therefore, risk factors for injuries related to professional horse racing need to be investigated. We conducted a study to determine whether body mass index (BMI) and γ-glutamyltransferase (GGT) levels are associated with professional horse racing-related injuries. Methods: A baseline healthy survey of 546 male grooms and exercise riders aged 40-70 yr working at Miho Training Center, the largest racing-horse training facility in Japan, was performed in May 2003. A total of 93 occupational injuries occurred from June 1, 2003 to December 31, 2005. The Cox proportional hazards model was used to examine associations between the risk of injury and BMI and GGT. Results: Grooms and exercise riders with BMI <20 kg/m2 or with BMI ≥25 kg/m2 compared to BMI=20.0-22.9 kg/m2 had 2.5 to 3.5-fold higher age-adjusted risks of injuries. The multivariate hazard ratios (95% confidence interval) after adjustment for age, GGT, smoking habit, and history of injuries were 3.5 (1.5 to 8.4) and 2.4 (1.2 to 4.8) for grooms, 3.1 (1.2 to 8.2) and 1.9 (0.4 to 10.1) for exercise riders, respectively. The age-adjusted hazard ratio of injuries for persons with GGT ≥100 IU/l was 2.0 to 2.5-fold higher than for those with GGT <60 IU/l. The multivariate hazard ratios were 1.9 (1.0 to 3.6) for grooms and 2.5 (1.0 to 6.2) for exercise riders. Conclusions: Low and high BMI and high GGT were associated with professional horse racing-related injuries.
- 著者
- Kiyohide Tomooka Isao Saito Shinya Furukawa Koutatsu Maruyama Eri Eguchi Hiroyasu Iso Takeshi Tanigawa
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- pp.JE20160169, (Released:2017-12-28)
- 参考文献数
- 46
- 被引用文献数
- 19
Background: Yellow tongue coating is one of the clinical signs for diabetes mellitus according to traditional East Asian medicine. Few reports have been available on the association between yellow tongue coating and the prevalence of type 2 diabetes in the general population. We examined that association among population samples of non-smoking men and women.Methods: The study subjects were Japanese non-smoking men (n = 315) and women (n = 654) aged 30–79 years who resided in Toon city and participated in the Toon Health Study from July 2011 through November 2014. Tongue coating was assessed by a nationally licensed acupuncturist and classified into three categories of white (normal), light yellow, and yellow. We performed an oral glucose tolerance test to confirm the presence of diabetes mellitus and prediabetes. The associations between yellow tongue coating and the prevalence of diabetes mellitus and prediabetes were examined using multivariable logistic regression analyses, adjusting for age, sex, body mass index, drinking status, and physical activity.Results: The multivariable odds ratios of diabetes mellitus were 1.39 (95% confidence interval [CI], 0.72–2.67) for light yellow tongue coating and 2.23 (95% CI, 1.16–4.30) for yellow tongue coating compared with white tongue coating. The respective multivariable odds ratios of prediabetes were 1.13 (95% CI, 0.80–1.61) and 1.43 (95% CI, 0.96–2.12).Conclusions: Yellow tongue coating was associated with higher prevalence of diabetes mellitus and tended to be associated with that of prediabetes among Japanese non-smoking men and women.
- 著者
- Shinya Furukawa Shin Yamamoto Yasuhiko Todo Kotatsu Maruyama Teruki Miyake Teruhisa Ueda Tetsuji Niiya Takatoshi Senba Masamoto Torisu Teru Kumagi Syozo Miyauchi Takenori Sakai Hisaka Minami Hiroaki Miyaoka Bunzo Matsuura Yoichi Hiasa Morikazu Onji Takeshi Tanigawa
- 出版者
- (社)日本内分泌学会
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- pp.EJ14-0206, (Released:2014-08-07)
- 被引用文献数
- 10 44
Subclinical hypothyroidism (SCH) has been associated with type 2 diabetes mellitus. However, it is unknown whether common complications of type 2 diabetes, such as diabetic nephropathy, are also present with SCH. Here, we investigated the association between SCH and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus. In this multicenter cross-sectional study, we recruited 414 such patients who had no previous history of thyroid disease. Serum thyroid hormone levels and the urinary albumin:creatinine ratio were measured. SCH was defined as an elevated thyroid-stimulating hormone (TSH) level (>4.0 mIU/L), and diabetic nephropathy was defined as creatinine levels ≥300 mg/g. The prevalence of SCH was 8.7% (n = 36) among patients with type 2 diabetes mellitus. The SCH group had a higher prevalence of dyslipidemia (p = 0.008) and diabetic nephropathy (p = 0.014) than the euthyroid group. Multivariate analysis identified significant positive associations between diabetic nephropathy and SCH (odds ratio [OR], 3.51; 95% confidence interval [CI], 1.10-10.0; p = 0.034), hypertension (OR, 4.56; 95% CI, 1.69-14.7; p = 0.001), and smoking (OR, 3.02; 95% CI, 1.14-7.91; p = 0.026). SCH may be independently associated with diabetic nephropathy in Japanese patients with type 2 diabetes mellitus.