- 著者
- Tetsuo KIMURA Naoki MUGURUMA Tatsuzo ITAGAKI Yoshitaka IMOTO Masako KAJI Hiroshi MIYAMOTO Seisuke OKAMURA Tetsuji TAKAYAMA Jouji SHUNTOU
- 出版者
- Japan Gastroenterological Endoscopy Society
- 雑誌
- GASTROENTEROLOGICAL ENDOSCOPY (ISSN:03871207)
- 巻号頁・発行日
- vol.50, no.6, pp.1448-1454, 2008-06-20 (Released:2011-05-09)
- 参考文献数
- 20
症例は63歳,男性.つるし柿6個を一度に食べた後に,腹痛・嘔吐が出現し近医を受診した.上部消化管内視鏡検査にて6cm大の胃石を認めた.柿胃石と判断し,近年の報告を参考にコカ・コーラの経口摂取や内視鏡下にERCP力ニューレを用いて直接散布などを行ったところ,数個の破片に崩壊,消失する経過が内視鏡的に観察された.本疾患に対するコカ・コーラによる溶解療法は安全かつ簡便で,医療経済的にも有用な方法であると考えられた.
- 著者
- Osamu TANAKA Satoshi CHIDA Tetsuo KIMURA Teruo SAITO Ryuichi KATO
- 出版者
- The Japanese Society of Clinical Pharmacology and Therapeutics
- 雑誌
- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics (ISSN:03881601)
- 巻号頁・発行日
- vol.13, no.3, pp.463-475, 1982-09-30 (Released:2010-06-28)
- 参考文献数
- 24
- 被引用文献数
- 4 2
A transdermal sustained release formulation. of isosorbide dinitrate (Frandol Tape) has been developed for the purpose of prolonging the preventive effect of isosorbide dinitrate (ISDN) against attacks of angina pectoris.The plasma levels of ISDN and the two metabolites, isosorbide 2-mononitrate and isosorbide 5-mononitrate, were measured after the application of Frandol Tape (ISDN 40mg) in ten healthy male volunteers. After a single application of the tape to the breast for 24 or 48 hrs, the mean plasma levels of ISDN increased slowly to reach their peaks of 2.6 or 2.7 ng/ml at 6 hrs and declined very slowly to 1.9 ng/ml at 24 hrs or to 1.4 ng/ml at 48 hrs after the application. After removal of the tape, the mean plasma levels of ISDN declined with a half-life of 2.3 hrs.The area under the plasma level versus time curve (AUC) for ISDN per the amount of ISDN absorbed percutaneously after a transdermal administration was larger than after an oral administration. Probably because ISDN was not susceptible to“first-pass effect” in the cutaneous route. On the other hand, it was suggested that urinary excretion behavior after a transdermal administration was similar to that after an oral administration.These results demonstrated that Frandol Tape might be an useful transdermal sustained release formulation of ISDN for the prevention of angina pectoris, since the plasma level of ISDN is maintained constantly during the period of application.