- 著者
- TORU KINO HIROSHI HATANAKA SUSUMU MIYATA NORIAKI INAMURA MICHIHISA NISHIYAMA TOSHIMI YAJIMA TOSHIO GOTO MASAKUNI OKUHARA MASANOBU KOHSAKA HATSUO AOKI TAKENORI OCHIAI
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.40, no.9, pp.1256-1265, 1987-09-25 (Released:2006-04-19)
- 参考文献数
- 16
- 被引用文献数
- 241 780
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent. The IC50 values of FK-506 and ciclosporin (CS) in all tests were approximately 0.1nM and 10nM, respectively. Therefore, the novel agent, FK-506 suppressed in vitro immune systems at about hundred times lower concentration than CS.
- 著者
- Minoru ISOBE Duangchan UYAKUL Jon B. SIGURDSSON Toshio GOTO Toong J. LAM
- 出版者
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- 雑誌
- Agricultural and Biological Chemistry (ISSN:00021369)
- 巻号頁・発行日
- vol.55, no.8, pp.1947-1951, 1991 (Released:2006-04-05)
- 参考文献数
- 13
The land snail, Dyakia striata, bioluminesces to exhibit green light. Its luminescence spectrum was recently reported by using juvenile snails to show the maximum at ca. 515 nm. In the current studies, a green fluorescent substance was extracted from the separated anterior head-foot of the adult snails, which contained the photogenic organs. The fluorescent substance, which showed the maximum ca. 515nm in its spectrum, was purified by chromatography. The partially purified green fluorescent substance was soluble only in organic solvents and not in water. The chromophore of the green fluorescent substance was compared with isoalloxazine and riboflavin acetate in different organic solvents under reductive and re-oxidative conditions.