著者
Takekatsu Shibata Ryuta Urakawa Chikako Ono Yukihiro Akeda Takayoshi Sakai Shigeto Hamaguchi Kiyoto Takamori Tsuyoshi Inoue Kazunori Tomono Kiyoshi Konishi Yoshiharu Matsuura
出版者
The Pharmaceutical Society of Japan
雑誌
BPB Reports (ISSN:2434432X)
巻号頁・発行日
vol.4, no.3, pp.78-84, 2021 (Released:2021-05-26)
参考文献数
39
被引用文献数
8

Matching transformation system (MA-T) is an on-demand aqueous chlorine dioxide solution. It is a disinfectant developed to maximize the safety of chlorine dioxide radical in water and its effectiveness against various microorganisms. In this study, we examined the safety and effectiveness of MA-T for its use in various infectious disease countermeasures, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and consider if MA-T can be implemented in society. To validate the safety of MA-T, we conducted safety tests and efficacy tests in accordance with GLP-based reliability criteria. To evaluate the efficacy, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) confirmation tests against various bacteria, and virus inactivation test against various viruses including SARS-CoV-2 by TCID50 method were performed. The results of safety tests showed that MA-T was at least as safe as Japanese tap water. As a result of efficacy tests for microorganisms, MA-T was effective against many bacteria. Efficacy tests for virus showed that MA-T inactivates SARS-CoV-1, Middle East respiratory syndrome coronavirus (MERS-CoV), rotavirus A (RV-A), hepatitis C virus (HCV), dengue virus (DENV), and hepatitis B virus (HBV). MA-T also inactivated 99.98% of SARS-CoV-2, which is equivalent to ethanol for disinfection. MA-T has proven to be a safe and effective disinfectant. MA-T is a next-generation disinfectant that has the potential to be safer and more effective than conventional chlorine disinfectants and other disinfectants. It also proved to be an effective disinfectant against SARS-CoV-2, which is currently causing pandemic all over the world.
著者
Shota YABUI Takenori ATSUMI Tsuyoshi INOUE
出版者
The Japan Society of Mechanical Engineers
雑誌
Journal of Advanced Mechanical Design, Systems, and Manufacturing (ISSN:18813054)
巻号頁・発行日
vol.13, no.4, pp.JAMDSM0078, 2019 (Released:2019-11-07)
参考文献数
28
被引用文献数
1 3

To increase recording density, a head positioning control system of a hard disk drive (HDD) has to compensate for vibration due to mechanical resonances of the system. In this study, a novel scheme of an adaptive feedforward cancellation (AFC) is proposed to compensate for the vibration due to the mechanical resonances. Compared to a notch filter, which is commonly used to compensate for the vibration, the proposed AFC has the advantage of estimating the amplitude of the vibration from the output signal. In addition, although the proposed AFC can be implemented as a discrete system, the design parameters: frequency, damping ratio, and gain can be set directly in a digital signal processor. The proposed control system was applied to a dual-stage actuator system, which is the mainstream head positioning control system of the current HDDs. The results indicate that the proposed system could compensate for the vibration due to the mechanical resonance.