著者

Masaru MAEBASHI Yoshio MAKINO Yuji FURUKAWA Kosaku OHINATA Shuichi KIMURA Takao SATO

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.14, no.3, pp.211-218, 1993 (Released:2010-02-25)

参考文献数

25

被引用文献数

68 85

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The therapeutic efficacy of biotin was evaluated in 43 patients with non-insulin dependent diabetes mellitus. The serum biotin concentration in the patients was significantly lower than that in the 64 healthy control subjects and inversely correlated with the fasting blood glucose level. The oral administration of biotin, 9mg daily, corrected the hyperglycemia in the patients with no change in their serum insulin level. The serum levels of pyruvate and lactate decreased to their normal ranges after the administration. These observations suggest that the biotin administration ameliorates abnormal glucose metabolism in diabetic patients, presumably by enhancing the activity of the biotin-dependent enzyme, pyruvate carboxylase, with a subsequent promotion of glucose utilization for the entry into the tricarboxylic acid cycle. The administration also enhanced the response to glibenclamide in patients who had been resistant to the agent, suggesting a significant increase in the potency of the endogenous insulin action. The result demonstrates that biotin administration is effective for the treatment of the patients. Neither a relapse of clinical symptoms nor an occurrence of undesirable side effects has been observed.

著者

Yuji FURUKAWA Kosaku OHINATA Michiyoshi IKAI Masaru MAEBASHI Hong ZHANG Shuichi KIMURA

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.18, no.1, pp.35-42, 1995 (Released:2010-02-25)

参考文献数

21

被引用文献数

3 3

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The insulin secretion expressed in terms of plasma concentration in response to an oral glucose load (1.8g per kg body weight) in biotin-deficient male Wistar rats was approximately one-sixth that of pair-fed controls. However, the insulin content of the pancreas in biotin-deficient rats was no lower than that of control rats. The reduction in insulin secretion in the biotin-deficient rats was reversed to a significant extent by the simultaneous administration of biotin (1mg per kg body weight) with the glucose solution. This suggests that biotin may play an important role in the secretion of insulin from the β-cells of the pancreas.

著者

古川 雄嗣 Yuji FURUKAWA

出版者

甲南大学人間科学研究所

雑誌

心の危機と臨床の知

巻号頁・発行日

vol.21, pp.97-114, 2020-03-20

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This lecture considers the kinds of problems that existed in Shuzo Kuki's life and how they influenced his philosophy. Centrally, The experience of his mother's misery was crucial to his work on the problem of contingency. When humans who periodically bear such a tragic reality, how can (or should) a person live in that reality ? Kuki's philosophy contains an answer to precisely this question. Kuki concludes that contingency should be understood as fate. Kuki's idea is that through subjective will meaningless contingencies should be given meanings. The lecture concludes by showing how Kuki's philosophy has contemporary significance.