著者

Masaya IGASE Yuki MORINAGA Masahiro KATO Toshihiro TSUKUI Yusuke SAKAI Masaru OKUDA Takuya MIZUNO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0667, (Released:2020-03-06)

被引用文献数

1

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DEP domain-containing 1B (DEPDC1B) is involved in the regulation of cell de-adhesion and actin cytoskeleton activity during the G2/M transition of the cell cycle, and its overexpression has been proven to be associated with cancer progression in several human cancers. Canine DEPDC1B was identified as a gene that was overexpressed in canine lymphoma tissues in our previous study. However, in dogs, the protein expression of DEPDC1B remains to be determined due to the lack of a specific monoclonal antibody. Here, we developed rat monoclonal antibodies against canine DEPDC1B and characterized their applicability for immunodetection assays. Our findings demonstrated that these antibodies are functional and can be important tools to investigate the precise role of DEPDC1B in canine tumors.

著者

Andrew H. Baird Alasdair J. Edwards James R. Guest Saki Harii Masayuki Hatta Liam Lachs Hanaka Mera Frederic Sinniger David Abrego Or Ben-Zvi Omri Bronstein Patrick C. Cabaitan Vivian R. Cumbo Gal Eyal Lee Eyal-Shaham Bar Feldman Joana Figueiredo Jean-François Flot Mila Grinblat Andrew Heyward Michio Hidaka Mamiko Hirose Akira Iguchi Naoko Isomura Robert A. Kinzie Seiya Kitanobo Alyson Kuba Oren Levy Yossi Loya Takuma Mezaki Amin R. Mohamed Masaya Morita Satoshi Nojima Yoko Nozawa Rian Prasetia Eneour Puill-Stephan Catalina Ramirez-Portilla Hanna Rapuano Yaeli Rosenberg Yusuke Sakai Kazuhiko Sakai Tom Shlesinger Tullia I. Terraneo Irina Yakovleva Hiromi H. Yamamoto Kiyoshi Yamazato

出版者

The Japanese Coral Reef Society

雑誌

Galaxea, Journal of Coral Reef Studies (ISSN:18830838)

巻号頁・発行日

pp.G2021_S10O, (Released:2021-11-19)

参考文献数

27

被引用文献数

11

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Sesoko Station, Okinawa, has been the site of many significant advances in coral reproductive research and it continues to be a preferred destination for both Japanese and international researchers. Consequently, there are decades of spawning observations, which we present and explore here with the aim of making it easier to predict when species spawn at Sesoko Station. The data include over 700 spawning observations from 87 species of reef-building hermatypic corals. Almost all spawning occurred between dusk and dawn, with most spawning activity concentrated in the 2 to 4 hours after sunset. Some phylogenetic patterns were evident: most Acropora species spawn on or around the 6th full moon after December 21st (the northern hemisphere winter solstice); spawning in common species of merulinids and Porites appears to be concentrated around the 7th full moon and spawning in the fungiids around the 8th and subsequent full moons. The night of peak spawning with respect to the night of the full moon varied considerably among years in common Acropora species, but was dependent on the calendar date of the full moon in May or June. Therefore, despite an extended spawning season of over three months and considerable variation in the calendar date of spawning in many species among years, the month and night of spawning are reasonably predictable for many species enhancing the value of Sesoko Station as a site for coral reproductive research.

著者

Yusuke SAKAI Keita EMURA Goichiro HANAOKA Yutaka KAWAI Kazumasa OMOTE

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E96.A, no.6, pp.1156-1168, 2013-06-01 (Released:2013-06-01)

参考文献数

27

被引用文献数

3 4

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This paper proposes methods for “restricting the message space” of public-key encryption, by allowing a third party to verify whether a given ciphertext does not encrypt some message which is previously specified as a “bad” (or “problematic”) message. Public-key encryption schemes are normally designed not to leak even partial information of encrypted plaintexts, but it would be problematic in some circumstances. This higher level of confidentiality could be abused, as some malicious parties could communicate with each other, or could talk about some illegal topics, using an ordinary public key encryption scheme with help of the public-key infrastructure. It would be undesirable considering the public nature of PKI. The primitive of restrictive public key encryption will help this situation, by allowing a trusted authority to specify a set of “bad” plaintexts, and allowing every third party to detect ciphertexts that encrypts some of the specified “bad” plaintext. The primitive also provides strong confidentiality (of indistinguishability type) of the plaintext when it is not specified as “bad.” In this way, a third party (possible a gateway node of the network) can examine a ciphertext (which comes from the network) includes an allowable content or not, and only when the ciphertext does not contain forbidden message, the gateway transfers the ciphertext to a next node. In this paper, we formalize the above requirements and provide two constructions that satisfied the formalization. The first construction is based on the techniques of Teranishi et al. (IEICE Trans. Fundamentals E92-A, 2009), Boudot (EUROCRYPT 2000), and Nakanishi et al. (IEICE Trans. Fundamentals E93-A, 2010), which are developed in the context of (revocation of) group signature. The other construction is based on the OR-proof technique. The first construction has better performance when very few messages are specified as bad, while the other does when almost all of messages are specified as bad (and only very few messages are allowed to encrypt).

著者

Munekazu NAKAICHI Toshie ISERI Hiro HORIKIRIZONO Yusuke SAKAI Harumichi ITOH Hiroshi SUNAHARA Kazuhito ITAMOTO Kenji TANI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0500, (Released:2020-10-06)

被引用文献数

1

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An 11-year-old male toy poodle with neurological symptoms was diagnosed with a macroscopic pituitary tumor, which produced adrenocorticotropic hormone. Radiation therapy with a linear accelerator was performed for the pituitary tumor, and resulted in good local tumor control. However, serum endogenous adrenocorticotropic hormone concentrations were uncontrollable even after the tumor disappeared. Abdominal computed tomography revealed splenic masses, and splenectomy was performed. Histopathological examination of the surgical specimen showed tumor cells with eosinophilic and finely granular cytoplasm suggestive of endocrine origin. Since these cells were positive for adrenocorticotropic hormone, the case was diagnosed as a pituitary carcinoma with distant metastasis. Necropsy revealed multiple metastases to the abdominal organs. This is the first case report describing canine pituitary carcinoma with distant metastasis.

著者

Masaya IGASE Yuki MORINAGA Masahiro KATO Toshihiro TSUKUI Yusuke SAKAI Masaru OKUDA Takuya MIZUNO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.82, no.4, pp.483-487, 2020 (Released:2020-04-15)

参考文献数

13

被引用文献数

1

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DEP domain-containing 1B (DEPDC1B) is involved in the regulation of cell de-adhesion and actin cytoskeleton activity during the G2/M transition of the cell cycle, and its overexpression has been proven to be associated with cancer progression in several human cancers. Canine DEPDC1B was identified as a gene that was overexpressed in canine lymphoma tissues in our previous study. However, in dogs, the protein expression of DEPDC1B remains to be determined due to the lack of a specific monoclonal antibody. Here, we developed rat monoclonal antibodies against canine DEPDC1B and characterized their applicability for immunodetection assays. Our findings demonstrated that these antibodies are functional and can be important tools to investigate the precise role of DEPDC1B in canine tumors.

著者

Ai ISHIDA Keita EMURA Goichiro HANAOKA Yusuke SAKAI Keisuke TANAKA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E98-A, no.12, pp.2446-2455, 2015-12-01

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The primitive called public key encryption with non-interactive opening (PKENO) is a class of public key encryption (PKE) with additional functionality. By using this, a receiver of a ciphertext can prove that the ciphertext is an encryption of a specified message in a publicly verifiable manner. In some situation that a receiver needs to claim that a ciphertext is NOT decrypted to a specified message, if he/she proves the fact by using PKENO straightforwardly, the real message of the ciphertext is revealed and a verifier checks that it is different from the specified message about which the receiver wants to prove. However, this naive solution is problematic in terms of privacy. Inspired by this problem, we propose the notion of disavowable public key encryption with non-interactive opening (disavowable PKENO) where, with respect to a ciphertext and a message, the receiver of the ciphertext can issue a proof that the plaintext of the ciphertext is NOT the message. Also, we give a concrete construction. Specifically, a disavowal proof in our scheme consists of 61 group elements. The proposed disavowable PKENO scheme is provably secure in the standard model under the decisional linear assumption and strong unforgeability of the underlying one-time signature scheme.