著者

Hiroaki Eshima David C Poole Yutaka Kano

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.7, no.4, pp.205-211, 2018-07-25 (Released:2018-07-18)

参考文献数

57

被引用文献数

1

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In skeletal muscle, resting cytosolic Ca2+ concentration ([Ca2+]cyto) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Specifically, skeletal muscle contractile function is critically dependent on effective SR Ca2+ handling. However, more recent studies have revealed that mitochondria are essentially involved in [Ca2+]cyto homeostasis during and following muscle contractions. We recently provided substantial support for the mitochondria as a major site for Ca2+ sequestration in skeletal muscle during recovery from fatiguing tetanic contractions under in vivo conditions. This review provides an overview of the role of skeletal muscle mitochondria in [Ca2+]cyto regulation in vivo during and following muscle contractions.

著者

Yutaka Kano

出版者

THE JAPAN STATISTICAL SOCIETY

雑誌

JOURNAL OF THE JAPAN STATISTICAL SOCIETY (ISSN:18822754)

巻号頁・発行日

vol.26, no.1, pp.101-117, 1996 (Released:2009-01-22)

参考文献数

43

被引用文献数

1 1

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Takeuchi [37], Takeuchi and Akahira [38] and Pfanzagl [27] among others proved that any first-order efficient estimators are second-order efficient. Many other authors e. g., Ghosh [15], have conjectured that any third-order efficient estimators are also fourth-order efficient. Based on the concentration probability of estimators about a true parameter, this paper gives a positive answer to the conjecture in a curved exponential family with multi-structural parameters. It is seen that choice of bias-correction factors is critical.

著者

Yutaka Kano

出版者

Japan Statistical Society

雑誌

日本統計学会誌 (ISSN:03895602)

巻号頁・発行日

vol.13, no.2, pp.137-144, 1983 (Released:2009-01-22)

参考文献数

7

被引用文献数

1

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In factor analysis both the maximum likelihood estimator and the generalized least squares estimator for the structural parameters (i.e. factor loadings and unique variances) are shown to be consistent weakly or strongly under Anderson and Rubin's sufficient condition for weak identifiability.

著者

Yutaka Kano Kazumi Masuda Hirotaka Furukawa Mizuki Sudo Kazuyuki Mito Kazuyoshi Sakamoto

出版者

日本生理学会

雑誌

The Journal of Physiological Sciences (ISSN:18806546)

巻号頁・発行日

vol.58, no.5, pp.349-355, 2008 (Released:2008-10-29)

参考文献数

37

被引用文献数

8 20

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This study examined the effects of a different number of eccentric contractions (ECs) on histological characteristics, surface electromyogram (EMG) parameters (integral EMG, iEMG; muscle fiber conduction velocity, MFCV; and action potential waveform), and isometric peak torque using the rat EC model. Male Wistar rats (n = 40) were anesthetized, and ECs were initiated in the tibialis anterior muscle via electrical stimulation while the muscle was being stretched by electromotor. The rats were grouped according to the number of ECs (EC1, EC5, EC10, EC20, EC30, EC40, and EC100). Three days after the ECs, surface EMG signals and isometric peak torque were measured during evoked twitch contractions via electrical stimulation of the peroneal nerve. The muscle damage was evaluated from hematoxylin-eosin (HE) stained cross sections as a relative number of damaged fibers to intact fibers. Intense histological muscle damage (approximately 50% to 70% of the fiber), loss of isometric peak torque, disturbance of action potential waveform, and depression of iEMG (approximately −60% to −70%) were observed at EC20, EC30, EC40, and EC100. On the other hand, the MFCV did not change in any EC group. Although muscle damage and pathological surface EMG signals were not found at EC10, isometric peak torque was reduced significantly. In conclusion, the extent of histological muscle damage is not proportionally related to the number of ECs. Muscle damage was reflected by iEMG and action potential waveforms, but not by MFCV, which remained unaffected even though approximately 50% to 70% of the fiber demonstrated injury.