著者

中西 裕 Yutaka NAKANISHI

出版者

昭和女子大学近代文化研究所

雑誌

学苑 (ISSN:13480103)

巻号頁・発行日

no.964, pp.1-11, 2021-02

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Arthur Conan Doyle abandoned Catholicism early on and later devoted himself to spiritualism. Looking at the composers mentioned in the Sherlock Holmes stories, many are Protestants, four of whom, Mendelssohn, Meyerbeer, Offenbach, and Wagner, wrote music using Martin Luther's Ein' feste Burg ist unser Gott. He also portrays the Huguenots who, after being chased out of France, resettled in the United States in The Refugees: A Tale of Two Continents. Doyle had a favorable view of Protestantism, especially the Lutheran and Huguenot varieties.

著者

中西 裕 Yutaka NAKANISHI

出版者

昭和女子大学近代文化研究所

雑誌

学苑 = Gakuen (ISSN:13480103)

巻号頁・発行日

no.964, pp.1-11, 2021-02-01

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Arthur Conan Doyle abandoned Catholicism early on and later devoted himself to spiritualism. Looking at the composers mentioned in the Sherlock Holmes stories, many are Protestants, four of whom, Mendelssohn, Meyerbeer, Offenbach, and Wagner, wrote music using Martin Luther’s Ein’ feste Burg ist unser Gott. He also portrays the Huguenots who, after being chased out of France, resettled in the United States in The Refugees: A Tale of Two Continents. Doyle had a favorable view of Protestantism, especially the Lutheran and Huguenot varieties.

著者

Hiroshi Iwasaki Masaki Wakamatsu Kazunari Sugihara Kyohei Kamio Satoshi Tsuji Junya Morita Yasuhiro Kurihara Tomoko Izumi Tomohiro Nishimoto Kohnosuke Kinoshita Yutaka Nakanishi Minoru Sasaki

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.45, no.4, pp.201-218, 2020 (Released:2020-04-01)

参考文献数

32

被引用文献数

2

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TP0446131, developed as an antidepressant agent, was found to cause lenticular opacity in a 13-week repeated-dose study in dogs. Histopathologically, the lenticular opacity was observed as a degeneration of the lens fibers, characterized by irregularity in the ordered arrangement of the fibers which is necessary to maintain the transparency of the lens, and was considered to manifest clinically as cataract. To evaluate the development mechanism of the lenticular opacity, the chemical constituents of the lens, which is known to be associated with the development of cataract, were examined. The results of liquid chromatography-tandem mass spectrometry analysis revealed an increase in the amplitudes of 3 unknown peaks in a dose- and time-dependent manner in the lens, with no remarkable changes in the other chemical components tested. In addition, the content of cholesterol, alterations of which have been reported to be associated with cataract, remained unchanged. The mass spectral data and chromatographic behavior of the 3 peaks indicated that these peaks corresponded to sterol-related substances, and that one of them was 7-dehydrocholesterol, a precursor of cholesterol biosynthesis. This finding suggested that TP0446131 exerts some effects on the cholesterol biosynthesis pathway, which could be involved in the development of the cataracts. Furthermore, increases in the levels of these sterol-related substances were also detected in the serum, and were, in fact, noted prior to the onset of the cataract, suggesting the possibility that these substances in the serum could be used as potential safety biomarkers for predicting the onset of cataract induced by TP0446131.