著者

小原 洋右

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.38, no.5, pp.216-224, 1971 (Released:2010-10-14)

参考文献数

16

著者

亀山 元帥

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.63, no.2, pp.127-139, 1996-04-15 (Released:2010-03-01)

参考文献数

45

被引用文献数

1 1

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Locus control region (LCR) is known to occur 5′-upstream of the globin gene clusters in humans and a number of other animals. It comprises four DNase I hypersensitive sites, HS 1-4, and has been considered to play a key role in regulating the globin gene expression in tissue- and developmental stage-specific manners. The occurrence of LCR in the rat genome, however, has not been documented so far. In the present study, the author intended to identify and analyze the rat β-LCR HS 1 and HS 2, in order to further facilitate studies on the regulatory mechanism involved in globin gene expression. The results obtained in this study are summerized as follows:1. A DNA region of about 700 bp on the rat genome was amplified by polymerase chain reaction (PCR) using synthetic primers derived from portions of the mouse β-LCR HS 2. The nucleotide sequence of the PCR product (R 700) shows 67% and 83% homologies with those of the human and mouse HS 2, respectively, indicating that R 700 represents β-LCR HS 2 of rats.2. In order to locate β-LCR HS 2 on the rat genome, a 7 kb DNA fragment (R 7, 000) harboring a region between β-LCR HS 2 and the ε 1-globin gene was obtained by PCR. Restriction endonuclease mapping of R 7, 000 revealed that the rat β-LCR HS 2 is located 6.0kb 5′-upstream relative to the cap site of the ε 1-globin gene.3. The rat β-LCR HS 1 was then located 4.2 kb 5′-upstream of the ε 1-globin gene by Southern blot hybridization of R 7, 000 using a human HS 1 probe. Nucleotide sequencing revealed that the rat HS 1 has 83% homology to the mouse HS 1.4. Comparisons of the structures of the rat β-LCR HS 1 and HS 2 with those of other animal species indicate that several motifs and consensus sequences for binding of transcription factors, such as NF-E 2/AP-1 and GATA-1, are well conserved during evolutional periods, indicating an indispensable role of LCR in globin gene expression

著者

秋元 勇治

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.36, no.1, pp.1-19, 1969-02-15 (Released:2010-12-22)

参考文献数

43

被引用文献数

2

---

1) The “waxing and waning”(w-w) was studied on 479 normal healthy subjects and 2, 264 patients with mis-cellaneous neuro-psychiatric disorders. All the subjects were over 16 years of age.2) The w-w has been considered as the rhythmicity of normal cerebral activity, but this is uncertain. The auth-or attempts to examine it's properties in this report. The characteristics of the w-w represented at least 40μV of it's maximum amplitude, ca. 1-2 sec. of it's duration, and two or three times difference between maximum and minimum amplitude, and the w-w is mo-re clear and typical by biporal than monoporal recording.3) The w-w can be seen more clearly and typically at the stage of drowsiness or relaxation, and it is more pro-minent in hyperventilation than in bemegride or pentetrazol provocation.4) There is no specificity of age. The w-w was observed in 11.3% of normalhealthy subjects.5) The w-w was markedly observed in the subjects with miscellaneous autonomic disturbances, migraine, arter-iosclerosis, neurotic states and brain damage or posttraumatic complaints.But with statistical procedures, es-pecially, it had much more dominance in the subjects with migraine, miscellaneous autonomic disturbances and posttraumatic complaints at the level of X2<0.01.6) In almost all the cases with posttraumatic complaints, the w-w may decrease or diminish during continuous observation, but in other cases (ex. neurotics, with miscellaneous autonomic disturbances) it may be contin-uous at all times whether symptoms are remaining or not.7) There were no significant changes of the w-w produced by any medications.8) Therefore the w-w is not an abnormal sign, but the “significant sign”, indicating the relationship between the “certain cerebral function” and some clinical conditions.

著者

薩田 清明 小川 真利子 真壁 明子 黒川 顕 大塚 敏文

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.50, no.3, pp.441-444, 1983-06-15 (Released:2009-07-10)

参考文献数

6

被引用文献数

1

著者

小口 昌美 内木 久郎

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.21, no.8, pp.597-599, 1954

著者

池田 龍二

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.58, no.5, pp.587-596, 1991-10-15 (Released:2010-10-14)

参考文献数

28

被引用文献数

76 117

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学生解剖学実習用本邦成人死体18体 (平均年齢65.4歳) の骨盤を用いて肉眼的に仙腸関節に分布する神経につき観察を行った. また, 病理解剖用本邦成人死体6体 (平均年齢60.8歳) の仙腸関節を採取し, 組織学的に関節周囲に分布する神経を観察し, 以下の結果を得た.1) 仙腸関節の前方の上部では, 第5腰神経前枝の支配が主であると思われた.2) 仙腸関節の前方の下部では, 第2仙骨神経前枝, または仙骨神経叢の支配が主であると思われた.3) 仙腸関節の後方の上部では, 第5腰神経後枝の外側枝が主に支配していると思われた.4) 仙腸関節の後方の下部では, 仙骨神経後枝の外側枝によって形成される神経叢の支配が主であると思われた.5) 関節面に入り込んでいる神経の枝の直径は部位により明らかな差はなく, 0.292mmから0.997mmまでであった.6) 鍍銀染色標本によると, 関節周囲の靱帯内, 関節包には, 0.2μmから2.5μmまでの太さの神経線維, 5種類の形態を示す神経終末が存在した.

著者

伊藤 憲祐 河野 潤 高橋 健 川本 雅司 小川 真紀

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.63, no.6, pp.495-498, 1996-12-15 (Released:2010-10-14)

参考文献数

6

被引用文献数

1

著者

中嶋 榮太郎

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.4, no.3, pp.425-435, 1933

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The vast majority of the patient who are suffering disease of the mouth, sets almost entirely based upon en route by caries teeth. And 90% of the civilized peoples are owing to tremendous suffering by caries teeth, and the patients of teeth, the patients of disease of the gingiva have dependable popularity service to acceptance medical treatment by the Dentist, however, as actual results, it is happend in many cases by monopolized medical treatment of the patients by the Doctors, surgeon, and other specify of the doctors as ear-nose-throat, in excuse with heavier and more substancial disease of the mouth.<BR>As to the demonstration of the oral hygiene, in the other hand, the vast majority of peoples have almost absolutely nothing by their cleans thoroughly-as to lack of knowledge of the Oral Hygiene.<BR>And for the advertisment and the propaganda "Oral Hygiene" in our country, as a long while habits, simply rely upon by the dentist. However, as to actively a profit opportunity for diagnosis and medical treatment of disease of the mouth are so extensive comment as too selfish against the universal keen dentists. They drop in with a hollow sound. Let's run it the best in copperative business contact maintained profit opportunities regarding "Oral Hygiene" both of the Doctor and the Dentists.<BR>As to the question of main points of view regarding the Oral Hygiene, at the present time, no matter where you have not any grow caries teeth, because caries teeth grow are based upon as the principal resources of disease of the mouth. As a preventive measures of caries teeth it is necessary that a perfect sanitary and changing condition rudiment as matter of fact, strictly select up the proper tooth brush which will be used at usual day, that is the reason why -extremely different an injury of teeth and for development drain and moreover as economy of the time. If you are used the proper tooth brush there is no spoil at all development drain and development cavity and rudiment of teeth, in the mean time cleans thoroughly, for which purpose just exactly the same formula likewise the same shape of teeth, not only that, to needful services a certain harder of the tooth brush, almost needful services 2m.m. a space between each bundle of tooth brush hairs.<BR>Very recently I have found the proper (?) tooth brush in rapid cleaning teeth, economy of operation and cleanliness so called "Cleaner-Tooth-Brush". I have strongly recommend to all users the world over-actively pushing universal popularity for "Oral Hygiene" and new and greater opportunities to select up the proper tooth brush as a preventive measures of Caries Teeth and Disease of the Mouth in your behalf and of your soldiers. (4/X 1932)

著者

猪鹿倉 恭子

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.56, no.6, pp.535-544, 1989-12-15 (Released:2009-07-10)

参考文献数

23

被引用文献数

1 1

---

To investigate the prognostic factors, 30 cases of hypertensive primary thalamic hemorrhages with a poor or fatal outcome were studied. The age of the patients ranged from 42 to 84 years (mean: 64.4). Their level of consciousness, ocular deviations and pupillary abnormalities were analyzed in relation to the estimated volume and the extension of the hematomas.The level of consciousness was classified according to neurological grading (NG) of Kanaya et al. Twelve cases (40.0%) were above NG 4a. In high-aged patients, NG 1 or 2 often indicated a poor prognosis. A downward deviation or gasing nose (also known as 'thalamic eyes') was found in 13 cases (43.3%). Pupillary abnormalities were seen in 26 cases, and bilateral miosis (14 cases) indicated a poor prognosis. The extension of the hematoma consisted of 'downward' (type D), 'lateral' (type L) and 'upward' (type U), and combinations there of. Types U and D were thought to portend a poor prognosis.The following factors were thought to indicate a poor prognosis: (1) uncontrollable high blood pressure, (2) upward extension of the hematoma associated with large ventricular cast, (3) downward ocular deviation, bilateral miosis and downward extension of the hematoma (the first two were considered as indication of the hypothalamus and the midbrain being affected), (4) advanced age.

著者

宮道 文夫

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.33, no.2, pp.128-134, 1966-04-15 (Released:2010-10-14)

参考文献数

39

著者

浅野 伍朗 石原島 繁彦

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.51, no.2, pp.156-162, 1984-04-15 (Released:2009-07-10)

参考文献数

29

著者

千葉 広子

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.28, no.2, pp.310-335, 1961-02-15 (Released:2010-10-14)

参考文献数

68

著者

加藤 昊

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.28, no.4, pp.1055-1070_6, 1961-04-15 (Released:2010-10-14)

参考文献数

22

著者

永井 進

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.53, no.4, pp.332-344, 1986-08-15 (Released:2009-12-04)

参考文献数

29

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One hundred and eighty gestational sac (GS) measurements by ultrasound echography were performed on 132 healthy pregnant women with an accurate gestational age of between five and twelve weeks. Their prenatal courses were uneventful and they delivered of babies appropriate for dates at term. The GS longest diameter in longitudinal section (LGS), the GS longest diameter making perpendicularity to LGS in the same section (VGS) and the GS longest horizontal diameter in transversal section (TGS) were measured in cm. GS maximum diameter, two directi-onal GS diameters (LGS·TGS, LGS·VGS, TGS·VGS) and three directional GS diameters (LGS·TGS ·VGS) were assessed by computer analysis for correlation with gestational age and for comparison.1) Good correlation was obtained between GS maximum diameter and gestational age, with a correlation coefficient of 0.926105 and a standard error of 0.624265.2) The geometric or arithmetric means of LGS and TGS correlated most with gestational age in two directional GS diameters. The aritbmetric means of LGS and TGS correlated with gestational age better than the geometric means, with a correlation coefficient of 0.936251 and a standard error of 0.594649.3) The arithmetric means of three directional GS diameters correlated with gestational age better than the geometric means, with a correlation coefficient of 0.947145 and a standard error of 0.542982.4) The above results indicated that the measurements of the arithmetric means of three directional GS diameters exceedingly reduces errors in estimating gestational age.5) A convertible table to estimate gestational age on GS maximum diameters, arithmetric means of LGS and TGS, and of three directional GS diameters was made.

著者

広瀬 貞雄

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.37, no.1, pp.1-17, 1970-02-15 (Released:2010-10-14)

参考文献数

89

著者

進藤 久夫

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.62, no.5, pp.439-446, 1995-10-15 (Released:2010-03-01)

参考文献数

18

被引用文献数

11 11

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The lumbar multifidus muscle was dissected with particular reference to its innervation in 10 Japanese adults and 10 fetuses from 5 to 10 months old. The results were as follows:1) The multifidus muscle attached to the spinous process of a lumbar vertebra was segmentally innervated by the medial branch of the dorsal ramus of the lumbar nerve on a level with the spinous process.2) The motor point of the nerve innervating the multifidus muscle in adults was slightly ventro-caudal to that portion of the lumbar spinous process with muscle attached.3) The multifidus muscle in fetuses was thinner and flatter than that in adults. The motor point of the nerve innervating this muscle was slightly caudal at the lateral margin of the muscle to that portion of the lumbar spinous process with the muscle attached. These differences can be attributed to the fact that muscles used to oppose gravity are undeveloped in fetuses.4) There was variation in 5 fascicles in total, in which the medial branch of the dorsal ramus of a lumbar nerve entered the multifidus muscle originating at the spinous process of a lower lumbar vertebra.

著者

柏原 正和

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.22, no.12, pp.1113-1114, 1955

著者

品川 嘉也

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.54, no.3, pp.333-338, 1987-06-15 (Released:2009-07-10)

参考文献数

10

著者

村田 朗

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.63, no.5, pp.404-408, 1996-10-15 (Released:2010-03-01)

参考文献数

4

著者

山寺 博史 中村 秀一 鈴木 英朗 遠藤 俊吉

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.64, no.1, pp.53-56, 1997

被引用文献数

1

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We experienced a 49 years old female SAD patient who showed a good response the next day after alprazolam 1.2 mg administration. The back ground EEG of the patient showed a abnormal EEG with slow waves. The personality was colored with histerical features. The nadir of body core temperature from rectum slightly delayed in remission phase compared with depressive phase. The patient became hypomania and calmed down gradually. Alprazolam tratment is seemed to be available for SAD patients. (J Nippon Med Sch 1997; 64: 53-56)