著者

Shinichi MEGURO Tomohito MIZUNO Kouji ONIZAWA Keiko KAWASAKI Hideaki NAKAGIRI Yumiko KOMINE Junko SUZUKI Yuji MATSUI Tadashi HASE Ichiro TOKIMITSU Hiroyuki SHIMASAKI Hiroshige ITAKURA

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.50, no.7, pp.593-598, 2001 (Released:2002-06-28)

参考文献数

29

被引用文献数

14 16 17

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Examination was made of the effects of tea catechins (TC) on diet-induced obesity. Exposure to high-fat-diet (30% fat) in C57BL/6J mice for 4 weeks induced significant increase in body weight, visceral fat (epididymal, mesenteric, retroperitoneal, perinephric) weight and plasma concentrations of glucose, triacylglycerol and leptin, compared to low-fat diet (5% fat). Treatment with 0.1%TC (high-fat diet +0.1%TC group) had little effect on diet-induced obesity. Relative to high-fat diet and 0.1%TC treatment, 0.5%TC treatment (high-fat diet +0.5%TC group) was noted to bring about significant decrease in body weight, visceral, fat weights and plasma leptin. Lipid absorption rate was the same with the high fat diet and 0.5%TC treatment. An oral soluble starch and sucrose (SS-S) tolerance test was conducted on C57BL/6J mice to evaluate the effects of TC to sugar absorption. When the ratio of TC to sum of SS-S was the same as that in the diet composition for the 0.5%TC treatment, the plasma glucose level showed no response. These results demonstrate for the first time TC to have antiobesity effects on diet-induced obesity in mice, and suggest these effects to be exerted through a mechanism that would not involve inhibition of intestinal absorption of sugar and lipid.

著者

Tomonori NAGAO Shinichi MEGURO Satoko SOGA Atsuko OTSUKA Kazuichi TOMONOBU Shinichi FUMOTO Akiro CHIKAMA Kenta MORI Masayuki YUZAWA Hiroyuki WATANABE Tadashi HASE Yukitaka TANAKA Ichiro TOKIMITSU Hiroyuki SHIMASAKI Hiroshige ITAKURA

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.50, no.9, pp.717-728, 2001 (Released:2002-06-28)

参考文献数

34

被引用文献数

33 36

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The body fat reducing effect of tea catechins was previously confirmed in humans. The effects of tea catechins for reducing body fat were thus studied as basis for actual application. Three experiments on healthy male adults (n=82) were conducted to determine the effects of long-term tea catechins administration on body fat and biochemical blood parameters. First experiment: tea catechins were given as oolong tea-like beverage for 12 weeks. In 600 and 900 mg groups, visceral fat was significantly loss than in the control (600 mg group p=0.0317, 900 mg group p=0.0098). The effects were more pronounced at greater of tea catechins administration. No significant changes in biochemical blood parameters including fat-soluble vitamins were detected. Second experiment : oolong tea-like beverage containing tea catechins at nearly same amounts on in the 600 mg group was given for 20 weeks. Abdominal fat, including visceral fat, was significantly loss than in the control (total fat area p<0.0001, visceral fat area p=0.0004, subcutaneous fat area p=0.0001). Plasma PAI-1 was also significantly decreased (p=0.0080). Third experiment : green tea-like (GT group) and oolong tea-like (OT group) beverages containing approximately 540 mg tea catechins were given for 12 weeks. In the two groups, visceral fat was significantly loss than in the control (GT group p=0.0284, OT group p=0.0095) and the effects of two beverages were similar. Long-term tea catechins administration at 500 to 600 mg/day in humans would thus appear to reduce body fat without influencing fat-soluble vitamins, of which the absorption may be inhibited, and various serum and plasma indices regardless of the kind of beverages.

著者

Seiichi Tobe Hiroshi Akimoto Hajime Shigematsu Toshiyuki Watanabe Masazumi Kikukawa Hiroshi Miyazawa

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.57, no.6, pp.353-358, 2008 (Released:2008-05-09)

参考文献数

24

被引用文献数

1 1

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We evaluated the allergen inactivating effect of colloidal silica by performing enzyme-liked immunosorbent assay (ELISA) whose wells were coated with 150 ng/mL of Japanese cedar pollen allergen (Cry j 1) or mite allergen (Der f 2). The allergens were almost 100% inactivated by 100 μg/mL of colloidal silica having a particle size 5 nm, and the inactivating effect was increased by aluminum binding to the surface of the colloidal silica. The results show that colloidal silica is a promising material for allergen inactivation. Since colloidal silica forms an insoluble nondispersive solid when dried, it is expected that airborne allergens can be reduced by binding them to colloidal silica.

著者

Kazuaki Miura

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.56, no.3, pp.123-128, 2007 (Released:2007-02-10)

参考文献数

11

被引用文献数

3 8

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The aquatic risk of 2-sulfonato fatty acid methyl ester sodium salt (MES) used in household detergents was assessed. The environmental exposure assessment expressed as predicted environmental concentration (PEC) was determined on the basis of monitoring results from the seven sites of four rivers in the urban area in Tokyo and Osaka. The 95 percentile as well as geometric mean of the MES concentration was found to exhibit a good correlation with the geometric mean of the Biochemical Oxygen Demand (BOD; the latter’s regression was grater than 0.99). The predicted no effect concentration (PNEC) for the aquatic environment was estimated by performing chronic assays of algae and daphnia. The risk characterization ratio (RCR: PEC/PNEC) was less than 1. Therefore, it is concluded that MES will not adversely affect the aquatic environment in Japan.

著者

Toshiharu TAKEI Hiroshi ODAKE Kazuaki MIURA Yutaka TAKAGI

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.3, pp.121-126, 2006 (Released:2006-02-11)

参考文献数

21

被引用文献数

3 4

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This paper reports the ecotoxicological study of “tetradecanoic acid, 2-sulfo-, 1-methylester, sodium salt (C14MES)”. This salt was synthesized by sulfonating 1-methyl tetradecanoic acid derived from palm oil and coconut oil with sulfur trioxide. The tests were attempted in accordance with the OECD (Organization for Economic Cooperation and Development) Guidelines for the Testing of Chemicals. The 72 h ErC50 exceeded 100 mg/L in the alga growth inhibition test. In the daphnia acute immobilization and reproduction tests, 17.2 mg/L of 48 h EC50 and 4.10 mg/L of NOEC were derived, respectively. These ecotoxicities of C14MES were equivalent to or lower than that of other similar anionic surfactants, such as LAS (linear alkylbenzene sulfonate) or AOS (alpha olefin sulfonate).