文献一覧: Springer Nature (出版者)

5 0 0 0 OA Weeding volatiles reduce leaf and seed damage to field-grown soybeans and increase seed isoflavones

著者: Shiojiri Kaori Ozawa Rika Yamashita Ken-Ichi Uefune Masayoshi Matsui Kenji Tsukamoto Chigen Tokumaru Susumu Takabayashi Junji
出版者: Springer Nature
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.7, 2017-01-30
被引用文献数: 11

草刈りの匂いで作物の防衛力を強化 --草刈り時の匂いを受容した大豆株では葉と豆の被害が減少し、豆中のイソフラボン量が増加する--. 京都大学プレスリリース. 2017-02-01.

2020-03-26 10:22:08
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3 0 0 0 OA Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.

著者: Ohta Ryo Niwa Akira Taniguchi Yukimasa Suzuki Naoya M Toga Junko Yagi Emiko Saiki Norikazu Nishinaka-Arai Yoko Okada Chihiro Watanabe Akira Nakahata Tatsutoshi Sekiguchi Kiyotoshi Saito Megumu K
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-11-02
被引用文献数: 36

細胞外マトリックスを用いてヒト多能性幹細胞から高効率に血管内皮細胞の誘導に成功. 京都大学プレスリリース. 2016-11-09.

2016-11-14 09:15:03
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3 0 0 0 OA MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells.

著者: Parr Callum J C Katayama Shota Miki Kenji Kuang Yi Yoshida Yoshinori Morizane Asuka Takahashi Jun Yamanaka Shinya Saito Hirohide
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-09-09
被引用文献数: 78

iPS細胞を選択的に識別・分離・除去できるしくみを合成RNAを用いて構築. 京都大学プレスリリース. 2016-09-09.

2016-10-10 06:15:50
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3 0 0 0 OA Advantage of straight walk instability in turning maneuver of multilegged locomotion: a robotics approach.

著者: Aoi Shinya Tanaka Takahiro Fujiki Soichiro Funato Tetsuro Senda Kei Tsuchiya Kazuo
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-07-22
被引用文献数: 26

ムカデはなぜあれほど機敏に動けるのだろうか?-多足ロボットを用いた実験的検証-. 京都大学プレスリリース. 2016-07-22.

2016-07-25 13:55:13
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2 0 0 0 OA Efficient Adhesion Culture of Human Pluripotent Stem Cells Using Laminin Fragments in an Uncoated Manner

著者: Miyazaki Takamichi Isobe Takehisa Nakatsuji Norio Suemori Hirofumi
出版者: Springer Nature
雑誌: Scientific Reports
巻号頁・発行日: vol.7, 2017-01-30
被引用文献数: 50

ヒト多能性幹細胞の拡大培養法の簡便かつ低コスト化に成功 : 培養基質のコーティングを必要としない培養法を開発. 京都大学プレスリリース. 2017-01-31.

2017-01-31 13:09:49
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2 0 0 0 OA Electronic Structure Evolution with Composition Alteration of Rh_xCu_y Alloy Nanoparticles.

著者: Palina Natalia Sakata Osami Kumara L. S. R. Song Chulho Sato Katsutoshi Nagaoka Katsutoshi Komatsu Tokutaro Kobayashi Hirokazu Kusada Kohei Kitagawa Hiroshi
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.7, 2017-01-25
被引用文献数: 12

組成が違っても触媒活性が同等な新規Rh-Cuナノ粒子の電子状態の観測 : 合金の複合的な電子状態が寄与することを示唆. 京都大学プレスリリース. 2017-01-30.

2017-01-30 12:08:02
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2 0 0 0 OA Superconductivity in the antiperovskite Dirac-metal oxide Sr[3−x]SnO

著者: Oudah Mohamed Ikeda Atsutoshi Hausmann Jan Niklas Yonezawa Shingo Fukumoto Toshiyuki Kobayashi Shingo Sato Masatoshi Maeno Yoshiteru
出版者: Springer Nature
雑誌: Nature Communications
巻号頁・発行日: vol.7, 2016-12-12
被引用文献数: 110

マイナス金属イオンを含む酸化物で超伝導を発見 : 逆ペロブスカイト酸化物初の超伝導体. 京都大学プレスリリース. 2016-12-13.

2016-12-13 17:43:09
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2 0 0 0 OA Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders.

著者: Komeda Hidetsugu Osanai Hidekazu Yanaoka Kaichi Okamoto Yuko Fujioka Toru Arai Sumiyoshi Inohara Keisuke Koyasu Masuo Kusumi Takashi Takiguchi Shinichiro Kawatani Masao Kumazaki Hirokazu Hiratani Michio Tomoda Akemi Kosaka Hirotaka
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-11-29
被引用文献数: 12

悪い子の良い行動から何を読み取るか? : 自閉スペクトラム症を持つ小学生・中学生の善悪判断. 京都大学プレスリリース. 2016-11-30.

2016-12-01 12:04:49
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1 0 0 0 OA Pathogenesis and therapeutic interventions for ANCA-associated vasculitis.

著者: Nakazawa Daigo Masuda Sakiko Tomaru Utano Ishizu Akihiro
出版者: Springer Nature
雑誌: Nature reviews. Rheumatology (ISSN:17594790)
巻号頁・発行日: vol.15, no.2, pp.91-101, 2019-02
被引用文献数: 259

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the serum. This disease entity includes microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and drug-induced AAV. Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. The mechanism by which ANCAs cause vasculitis involves ANCA-mediated excessive activation of neutrophils that subsequently release inflammatory cytokines, reactive oxygen species and lytic enzymes. In addition, this excessive activation of neutrophils by ANCAs induces formation of neutrophil extracellular traps (NETs). Although NETs are essential elements in innate immunity, excessive NET formation is harmful to small vessels. Moreover, NETs are involved not only in ANCA-mediated vascular injury but also in the production of ANCAs themselves. Therefore, a vicious cycle of NET formation and ANCA production is considered to be involved in the pathogenesis of AAV. In addition to this role of NETs in AAV, some other important discoveries have been made in the past few years. Incorporating these new insights into our understanding of the pathogenesis of AAV is needed to fully understand and ultimately overcome this disease.

2022-05-20 16:14:20
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1 0 0 0 IR Vibrational spectroscopy analysis of ligand efficacy in human M₂ muscarinic acetylcholine receptor (M₂R)

著者: 片山耕大魲洸平寿野良二木瀬亮次辻本浩一岩田想井上飛鳥小林拓也神取秀樹
出版者: Springer Nature
雑誌: Communications Biology
巻号頁・発行日: no.4, 2021

振動分光法を駆使した薬剤効能測定法の開発 --アセチルコリン受容体を標的とした神経疾患の治療薬開発への期待--. 京都大学プレスリリース. 2021-12-01.

2021-12-24 20:00:00
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https://ci.nii.ac.jp/naid/120007173788

1 0 0 0 IR Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

著者: Yoshimaru Tetsuro Aihara Keisuke Komatsu Masato Matsushita Yosuke Okazaki Yasumasa Toyokuni Shinya Honda Junko Sasa Mitsunori Miyoshi Yasuo Otaka Akira Katagiri Toyomasa
出版者: Springer Nature
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.7, 2017-05-12
被引用文献数: 11

Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex plays a crucial role in E2/ERα signalling modulation in breast cancer cells. Moreover, specific inhibition of the BIG3-PHB2 interaction using the ERα activity-regulator synthetic peptide (ERAP: 165–177 amino acids), derived from α-helical BIG3 sequence, resulted in a significant anti-tumour effect. However, the duration of this effect was very short for viable clinical application. We developed the chemically modified ERAP using stapling methods (stapledERAP) to improve the duration of its antitumour effects. The stapledERAP specifically inhibited the BIG3-PHB2 interaction and exhibited long-lasting suppressive activity. Its intracellular localization without the membrane-permeable polyarginine sequence was possible via the formation of a stable α-helix structure by stapling. Tumour bearing-mice treated daily or weekly with stapledERAP effectively prevented the BIG3-PHB2 interaction, leading to complete regression of E2-dependent tumours in vivo. Most importantly, combination of stapledERAP with tamoxifen, fulvestrant, and everolimus caused synergistic inhibitory effects on growth of breast cancer cells. Our findings suggested that the stapled ERAP may be a promising anti-tumour drug to suppress luminal-type breast cancer growth.

2019-07-11 05:45:14
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1 0 0 0 IR Deficit of state-dependent risk attitude modulation in gambling disorder

著者: Fujimoto A Tsurumi K Kawada R Murao T Takeuchi H Murai T Takahashi H
出版者: Springer Nature
雑誌: Translational Psychiatry (ISSN:21583188)
巻号頁・発行日: vol.7, 2017-04-04
被引用文献数: 17

ギャンブル依存症の神経メカニズム --前頭葉の一部の活動や結合の低下でリスクの取り方の柔軟性に障害--. 京都大学プレスリリース. 2017-04-05.Gambling disorder (GD) is often considered as a problem of trait-like risk preference. However, the symptoms of GD cannot be fully understood by this trait view. In the present study, we hypothesized that GD patients also had problem with a flexible control of risk attitude (state-dependent strategy optimization), and aimed to investigate the mechanisms underlying abnormal risk-taking of GD. To address this issue, we tested GD patients without comorbidity (GD group: n=21) and age-matched healthy control participants (HC group: n=29) in a multi-step gambling task, in which participants needed to clear 'block quota' (required units to clear a block, 1000–7000 units) in 20 choices, and conducted a task-functional magnetic resonance imaging (fMRI) experiment. Behavioral analysis indeed revealed a less flexible risk-attitude change in the GD group; the GD group failed to avoid risky choice in a specific quota range (low-quota condition), in which risky strategy was not optimal to solve the quota. Accordingly, fMRI analysis highlighted diminished functioning of the dorsolateral prefrontal cortex (dlPFC), which has been heavily implicated in cognitive flexibility. To our knowledge, the present study provided the first empirical evidence of a deficit of state-dependent strategy optimization in GD. Focusing on flexible control of risk attitude under quota may contribute to a better understanding of the psychopathology of GDs.