著者
岡田 章 松本 結希 山越 達也 西川 誠 福島 恵造 杉岡 信幸
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.12, pp.716-725, 2014-12-10 (Released:2015-12-10)
参考文献数
25

Recently, use of inhaled corticosteroid anti-asthmatic drugs has been increasing due to the increase of bronchial asthma patients. However, there are some side effects of inhaled corticosteroid, such as hoarseness, which can affect a patient's quality of life (QOL). Therefore, to contribute to the proper and individual use of these anti-asthmatic drugs, we conducted a statistical analysis to determine the cause of hoarseness by collecting information to find a relationship between the rate of patients suffering from hoarseness, their personal backgrounds and each inhaled corticosteroid.In our present study, the rate of hoarseness onset in smokers was 4.15 times higher than that of non-smokers. On the other hand, fluticasone propionate (FP) is the component of inhaled anti-asthmatic drugs, which has the largest average particle size. Rate of hoarseness onset of inhaled FP was higher than any other component of inhaled corticosteroids. However, in inhaled anti-asthmatic drugs having FP as the main corticosteroid component, difference of the onset of hoarseness was observed between five nozzle types of devices. This result suggested that the cause of this difference was derived from the individual shape of the device's nozzle.In this study, it was revealed that the difference in nozzle types of devices and the particle size of drug components affect mainly the occurrence frequency of hoarseness. These results provide helpful information about appropriate use of inhaled anti-asthmatic drugs including effective patient education for self-administration.

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ちなみにステロイド吸入後のうがいは口腔内カンジダを抑制するけど、嗄声の抑制には寄与しないらしい
正答:5 エアゾールはドライパウダーと比較して嗄声が生じにくいとする報告がある https://t.co/JQRu2hIjIr
10へぇ https://t.co/cRZFMkdBPR
https://t.co/NxskDrEqZ4 https://t.co/Nud0hmEK1S わっかんね_(┐「ε:)_ 試しても良いかなーって感じだけれど、シクレソニドに変えるのが良いような気もする。 https://t.co/r6bFDEOZe4
@ccb_nk 菅原先生のビジアブの本で書かれてたのは見ました(口腔カンジダの発現率でしたが)一応有意にDPIより少なかったそうです https://t.co/BFf2wpdyou あとこんなのも。まぁ変えてみるのも一つの手かなーくらいですかねぇ。
個人的なメモ 吸入ステロイド薬の副作用である嗄声発現の要因解析 https://t.co/szUYY9zHZv

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