- 著者
-
佐伯 万騎男
- 出版者
- 日本歯科薬物療法学会
- 雑誌
- 歯科薬物療法 (ISSN:02881012)
- 巻号頁・発行日
- vol.38, no.3, pp.191-194, 2019 (Released:2020-03-31)
- 参考文献数
- 13
Neuropathic pain is now defined by the International Association for the Study of Pain as pain caused by a lesion or disease of the somatosensory nervous system. The guidelines recommend tricyclic antidepressants, gabapentin or pregabalin, and duloxetine, a serotonin noradrenaline reuptake inhibitor, as first line. Mirogabalin, which is a novel ligand for the α2δ subunit of voltage-gated calcium channels, is being developed for treating neuropathic pain including diabetic peripheral neuropathy and postherpetic neuralgia. In this review, serendipitous discovery of pregabarin by Richard Silverman is discussed.