著者
佐伯 万騎男
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.38, no.3, pp.191-194, 2019 (Released:2020-03-31)
参考文献数
13

Neuropathic pain is now defined by the International Association for the Study of Pain as pain caused by a lesion or disease of the somatosensory nervous system. The guidelines recommend tricyclic antidepressants, gabapentin or pregabalin, and duloxetine, a serotonin noradrenaline reuptake inhibitor, as first line. Mirogabalin, which is a novel ligand for the α2δ subunit of voltage-gated calcium channels, is being developed for treating neuropathic pain including diabetic peripheral neuropathy and postherpetic neuralgia. In this review, serendipitous discovery of pregabarin by Richard Silverman is discussed.

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直近の裁判例にある「イソブチルGABA」事件、以下の論文を読んで技術的背景が少し理解できました。 神経障害性疼痛治療薬プレガバリン(リリカ®)の開発 https://t.co/4KIaQCcDUi

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