著者
佐藤 隆
出版者
日本香粧品学会
雑誌
日本香粧品学会誌 (ISSN:18802532)
巻号頁・発行日
vol.40, no.1, pp.8-11, 2016-03-31 (Released:2017-05-12)
参考文献数
30

Sebum production and secretion in sebaceous glands play important roles in the formation of a thin lipid layer as a physiological barrier on the skin's surface. The secretion of sebum is considered to be controlled in concert with the regulation of sebum production, in which insulin/insulin-like growth factor 1, 5α-dihydrotestosterone, corticotrophin-releasing hormone, and eicosanoids are involved under physiological and pathological conditions. In addition, environmental stimuli such as ultraviolet (UV) irradiation and temperature change have been reported to influence sebum secretion as well as its production. Furthermore, the abnormalities of sebum production and secretion are likely to disrupt the skin barrier functions and to cause sebaceous gland disorders such as acne, seborrhea, and xerosis. On the other hand, the regulation of sebum secretion has been generally defined to be due to a holocrine mechanism, which may contain apoptosis of sebaceous gland cells (sebocytes). In contrast, the apoptosis-independent sebum secretion by polymethoxy flavonoids and UVB has been reported in differentiated hamster sebocytes. Therefore, in addition to sebocyte-specific lipogenetic mechanisms, another unique sebum secretion pathway distinct from the holocrine mechanism is likely to exist in sebaceous glands.

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外部データベース (DOI)

Twitter (3 users, 3 posts, 4 favorites)

@sunchysan それはわからないです。乾燥しすぎて皮脂が出るってネットとかで見るんですが根拠がないのであまり信じてないんです。皮脂は男性ホルモンなどで調節されてるので、そこのスイッチがオンになってるのかなと https://t.co/JmE66emI2Q
なんか読んだことあると思ったんだけどたぶんSL2で読んだな https://t.co/otKn0DvEBk
2.ホルモン応答についてについて 皮脂分泌量はホルモン由来が支配的ことも仮説の根拠の一つ。紫外線や外気温の変化などによって皮脂分泌量が影響されることは知られていますが、一時的。 洗顔の前後では皮脂分泌量は然程増減していない可能性があります

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