著者
Nobuyoshi Ozawa Kiyoshi Ito Toru Tase Hirohito Metoki Nobuo Yaegashi
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.240, no.2, pp.147-151, 2016 (Released:2016-10-15)
参考文献数
8
被引用文献数
5 7

Prevention of cervical cancer has been unsuccessful in Japan because of low rates of cancer screening and vaccination. The Vaccine Adverse Review Committee of the Japanese Government investigated 2,475 adverse events and reported 617 (6.9/100,000) severe cases and 176 (2.0/100,000) cases with chronic pain. The proactive recommendation for human papillomavirus (HPV) vaccination has been suspended since June 2013. In this study, we examined vaccination rate and incidence of abnormal cervical cytology in women aged 20 to 24 years attending cancer screening in Miyagi. Among the 3,272 women who underwent a health check in the fiscal year 2014 (April 2014-March 2015), 332 (10.2%) received a HPV vaccination. The HPV vaccination rates were 42.3%, 10%, 17.5%, 3.8% and 4.0% in women aged 20, 21, 22, 23 and 24 years, respectively. The rates of atypical squamous cells of undetermined significance (ASC-US) or worse were 2.41% (8/332) in women with HPV vaccination and 5.03% (148/2,940) in those without HPV vaccination, indicating a significant decrease in vaccinated women (p = 0.03). ASC-US cases were referred to HPV DNA tests. In addition, the rates of high grade squamous intraepithelial lesion (HSIL) or worse were 0.30% (1/332) in women with HPV vaccination and 0.82% (24/2,940) in those without HPV vaccination, showing the marginal decrease in women who were vaccinated (p = 0.3). Thus, this study indicates that HPV vaccination is associated with a reduction in the incidence of cervical abnormalities, suggesting a need for scientific discussion of reinstatement of proactive recommendation for HPV vaccine in Japan.

言及状況

外部データベース (DOI)

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論文の問題点。Tohoku J Exp Medというインパクトファクターが非常に低いジャーナルに掲載されたのは合点がいく。普通の論文では論文の限界(limitations)を記載するがなし。 HPVワクチン接種群の数が、332人と… https://t.co/A8FEOyBf4a
宮城県調査、HPVワクチン、子宮頸部病変が軽度以上の異常がワクチン接種群で有意に減少し半減している。ゼロになってはいない。非ワクチン型が半数占めるためであろう。高度異常は半減しているが、有意差はなし。症例数が少ないためであろう。定… https://t.co/9bSwOfzJl7
Beneficial Effects of HPV Vaccine for Prevention of Cervical Abnormalities in Miyagi, Japan: https://t.co/TU5NHwZAIy ASCUS+ lower, n small.

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